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    Gpsm2 G-protein signaling modulator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362021, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Gpsm2provided by RGD
    Official Full Name
    G-protein signaling modulator 2provided by RGD
    Primary source
    RGD:1560967
    See related
    EnsemblRapid:ENSRNOG00000012149 AllianceGenome:RGD:1560967
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560967
    Summary
    Predicted to enable several functions, including G-protein alpha-subunit binding activity; dynein complex binding activity; and protein C-terminus binding activity. Predicted to be involved in several processes, including Ran protein signal transduction; maintenance of centrosome location; and regulation of spindle organization. Predicted to act upstream of or within establishment of mitotic spindle orientation and lung epithelial cell differentiation. Predicted to be located in several cellular components, including apical part of cell; centrosome; and lateral cell cortex. Predicted to be part of protein-containing complex. Predicted to colocalize with cell cortex and mitotic spindle pole. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Orthologous to human GPSM2 (G protein signaling modulator 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 66.5), Uterus (RPKM 66.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpsm2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (199015250..199063788, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (196327149..196375322, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (211480120..211528096, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 47 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene chloride channel CLIC-like 1 Neighboring gene AKNA domain containing 1 Neighboring gene uncharacterized LOC102547393 Neighboring gene syntaxin binding protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GPSM2 mutations cause the brain malformations and hearing loss in Chudley-McCullough syndrome. Doherty D, et al. Am J Hum Genet, 2012 Jun 8. PMID 22578326, Free PMC Article
    2. A truncating mutation in GPSM2 is associated with recessive non-syndromic hearing loss. Yariz KO, et al. Clin Genet, 2012 Mar. PMID 21348867, Free PMC Article
    3. Crystal structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Gαi. Jia M, et al. J Biol Chem, 2012 Oct 26. PMID 22952234, Free PMC Article
    4. LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways. Zhu J, et al. Mol Cell, 2011 Aug 5. PMID 21816348, Free PMC Article
    5. A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization. Du Q, et al. Nat Cell Biol, 2001 Dec. PMID 11781568

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP-dissociation inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP-dissociation inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of centrosome location ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    G-protein-signaling modulator 2
    Names
    G-protein signaling modulator 2 (AGS3-like, C. elegans)
    G-protein signalling modulator 2 (AGS3-like, C. elegans)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191962.1 → NP_001178891.1  G-protein-signaling modulator 2

      See identical proteins and their annotated locations for NP_001178891.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D3ZCE5
      Related
      ENSRNOP00000062330.2, ENSRNOT00000066178.6
      Conserved Domains (5) summary
      smart00390
      Location:490 → 512
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      COG0457
      Location:27 → 286
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:243 → 270
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:243 → 314
      TPR_12; Tetratricopeptide repeat
      pfam02188
      Location:594 → 613
      GoLoco; GoLoco motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      199015250..199063788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761411.3 → XP_008759633.1  G-protein-signaling modulator 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AGM3
      Related
      ENSRNOP00000092477.2, ENSRNOT00000107541.2
      Conserved Domains (5) summary
      smart00390
      Location:471 → 493
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      COG0457
      Location:8 → 267
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:224 → 251
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:224 → 295
      TPR_12; Tetratricopeptide repeat
      pfam02188
      Location:575 → 594
      GoLoco; GoLoco motif

    2. XM_008761409.3 → XP_008759631.1  G-protein-signaling modulator 2 isoform X1

      See identical proteins and their annotated locations for XP_008759631.1

      UniProtKB/TrEMBL
      D3ZCE5
      Conserved Domains (5) summary
      smart00390
      Location:490 → 512
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      COG0457
      Location:27 → 286
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:243 → 270
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:243 → 314
      TPR_12; Tetratricopeptide repeat
      pfam02188
      Location:594 → 613
      GoLoco; GoLoco motif

    3. XM_039102710.2 → XP_038958638.1  G-protein-signaling modulator 2 isoform X1

      UniProtKB/TrEMBL
      D3ZCE5
      Conserved Domains (5) summary
      smart00390
      Location:490 → 512
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      COG0457
      Location:27 → 286
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:243 → 270
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:243 → 314
      TPR_12; Tetratricopeptide repeat
      pfam02188
      Location:594 → 613
      GoLoco; GoLoco motif

    4. XM_039102712.2 → XP_038958640.1  G-protein-signaling modulator 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AGM3
      Conserved Domains (5) summary
      smart00390
      Location:471 → 493
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      COG0457
      Location:8 → 267
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:224 → 251
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:224 → 295
      TPR_12; Tetratricopeptide repeat
      pfam02188
      Location:575 → 594
      GoLoco; GoLoco motif
    Nucleotide Protein Strain
    Heading Accession and Version

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