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    Lrrfip1 LRR binding FLII interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367314, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Lrrfip1provided by RGD
    Official Full Name
    LRR binding FLII interacting protein 1provided by RGD
    Primary source
    RGD:1359548
    See related
    EnsemblRapid:ENSRNOG00000019892 AllianceGenome:RGD:1359548
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of NF-kappaB transcription factor activity. Predicted to be located in cytosol and plasma membrane. Orthologous to human LRRFIP1 (LRR binding FLII interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 206.1), Heart (RPKM 149.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    9q36
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (99039590..99167805)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (91592032..91720250)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (98139484..98268148)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene prolactin releasing hormone Neighboring gene RAB17, member RAS oncogene family Neighboring gene RNA binding motif protein 44 Neighboring gene receptor activity modifying protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The alternatively spliced LRRFIP1 Isoform-1 is a key regulator of the Wnt/β-catenin transcription pathway. Labbé P, et al. Biochim Biophys Acta Mol Cell Res, 2017 Jul. PMID 28322931
    2. Characterization of Gcf2/Lrrfip1 in experimental cerebral ischemia and its role as a modulator of Akt, mTOR and β-catenin signaling pathways. Gubern C, et al. Neuroscience, 2014 May 30. PMID 24637094
    3. The microRNA miR-132 targets Lrrfip1 to block vascular smooth muscle cell proliferation and neointimal hyperplasia. Choe N, et al. Atherosclerosis, 2013 Aug. PMID 23880186
    4. Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1. Nguyen JB, et al. J Struct Biol, 2013 Jan. PMID 23099021, Free PMC Article
    5. GCF2: expression and molecular analysis of repression. Rikiyama T, et al. Biochim Biophys Acta, 2003 Oct 1. PMID 14522076

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LRRFIP1-Iso1 is a muscle and cardiomyocyte specific Wnt transcription co-factor.
      Title: The alternatively spliced LRRFIP1 Isoform-1 is a key regulator of the Wnt/β-catenin transcription pathway.
    2. Results identify LRRFIP1, SMARCA4, and DNMT1 as novel regulators of macrophage multinucleation.
      Title: Integrating phosphoproteome and transcriptome reveals new determinants of macrophage multinucleation.
    3. First report to identify the different transcriptional variants of Lrrfip1 in the brain and to characterize their differential expression patterns and the subcellular location of the main isoform rLrrfip1 in ischemic conditions
      Title: Characterization of Gcf2/Lrrfip1 in experimental cerebral ischemia and its role as a modulator of Akt, mTOR and β-catenin signaling pathways.
    4. Our results suggest that miR-132 is a novel regulator of vascular smooth muscle cells proliferation that represses neointimal formation by inhibiting LRRFIP1 expression.
      Title: The microRNA miR-132 targets Lrrfip1 to block vascular smooth muscle cell proliferation and neointimal hyperplasia.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat flightless-interacting protein 1
    Names
    LRR FLII-interacting protein 1
    leucine rich repeat (in FLII) interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014269.1 → NP_001014291.1  leucine-rich repeat flightless-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001014291.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081883
      UniProtKB/Swiss-Prot
      Q66HF9
      UniProtKB/TrEMBL
      A0A8L2QNX6, A6JQP6
      Related
      ENSRNOP00000045021.3, ENSRNOT00000050191.4
      Conserved Domains (1) summary
      pfam09738
      Location:42 → 278
      DUF2051; Double stranded RNA binding protein (DUF2051)

    2. NM_001429351.1 → NP_001416280.1  leucine-rich repeat flightless-interacting protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      99039590..99167805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245444.5 → XP_006245506.1  leucine-rich repeat flightless-interacting protein 1 isoform X1

      Related
      ENSRNOP00000112353.1, ENSRNOT00000153243.1
      Conserved Domains (2) summary
      pfam09738
      Location:260 → 572
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl12057
      Location:410 → 487
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    2. XM_006245458.5 → XP_006245520.1  leucine-rich repeat flightless-interacting protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A8L2QNX6
      Conserved Domains (1) summary
      pfam09738
      Location:52 → 288
      DUF2051; Double stranded RNA binding protein (DUF2051)

    3. XM_006245459.4 → XP_006245521.1  leucine-rich repeat flightless-interacting protein 1 isoform X23

      UniProtKB/TrEMBL
      A6JQN7
      Conserved Domains (2) summary
      COG1340
      Location:410 → 680
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cl12057
      Location:410 → 487
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    4. XM_039083994.1 → XP_038939922.1  leucine-rich repeat flightless-interacting protein 1 isoform X28

      UniProtKB/TrEMBL
      A6JQN7
      Conserved Domains (2) summary
      pfam09738
      Location:260 → 582
      LRRFIP; LRRFIP family
      pfam11932
      Location:598 → 657
      DUF3450; Protein of unknown function (DUF3450)

    5. XM_006245462.5 → XP_006245524.1  leucine-rich repeat flightless-interacting protein 1 isoform X31

      UniProtKB/TrEMBL
      A6JQN8
      Conserved Domains (1) summary
      pfam09738
      Location:260 → 550
      DUF2051; Double stranded RNA binding protein (DUF2051)

    6. XM_063267530.1 → XP_063123600.1  leucine-rich repeat flightless-interacting protein 1 isoform X26

      UniProtKB/TrEMBL
      A6JQN7

    7. XM_039083995.2 → XP_038939923.1  leucine-rich repeat flightless-interacting protein 1 isoform X30

      UniProtKB/TrEMBL
      A6JQN7
      Conserved Domains (2) summary
      pfam09738
      Location:260 → 558
      LRRFIP; LRRFIP family
      pfam11932
      Location:574 → 633
      DUF3450; Protein of unknown function (DUF3450)

    8. XM_006245463.5 → XP_006245525.1  leucine-rich repeat flightless-interacting protein 1 isoform X34

      UniProtKB/TrEMBL
      A6JQN8
      Conserved Domains (1) summary
      pfam09738
      Location:260 → 526
      DUF2051; Double stranded RNA binding protein (DUF2051)

    9. XM_006245460.5 → XP_006245522.1  leucine-rich repeat flightless-interacting protein 1 isoform X25

      UniProtKB/TrEMBL
      A6JQN7
      Conserved Domains (1) summary
      COG1340
      Location:395 → 665
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

    10. XM_063267533.1 → XP_063123603.1  leucine-rich repeat flightless-interacting protein 1 isoform X33

      UniProtKB/TrEMBL
      A6JQN8

    11. XM_063267531.1 → XP_063123601.1  leucine-rich repeat flightless-interacting protein 1 isoform X29

      UniProtKB/TrEMBL
      A6JQN7

    12. XM_063267532.1 → XP_063123602.1  leucine-rich repeat flightless-interacting protein 1 isoform X32

      UniProtKB/TrEMBL
      A6JQN7

    13. XM_063267534.1 → XP_063123604.1  leucine-rich repeat flightless-interacting protein 1 isoform X35

      UniProtKB/TrEMBL
      A6JQN7

    14. XM_063267535.1 → XP_063123605.1  leucine-rich repeat flightless-interacting protein 1 isoform X36

      UniProtKB/TrEMBL
      A0A8I5ZPV3

    15. XM_063267536.1 → XP_063123606.1  leucine-rich repeat flightless-interacting protein 1 isoform X37

      UniProtKB/TrEMBL
      A0A8I5ZPV3

    16. XM_063267537.1 → XP_063123607.1  leucine-rich repeat flightless-interacting protein 1 isoform X38

      UniProtKB/TrEMBL
      A0A8I5ZPV3

    17. XM_063267538.1 → XP_063123608.1  leucine-rich repeat flightless-interacting protein 1 isoform X39

      UniProtKB/TrEMBL
      A6JQP5

    18. XM_039083999.2 → XP_038939927.1  leucine-rich repeat flightless-interacting protein 1 isoform X47

      UniProtKB/TrEMBL
      A6JQP5
      Conserved Domains (2) summary
      pfam09738
      Location:52 → 415
      LRRFIP; LRRFIP family
      pfam11932
      Location:431 → 490
      DUF3450; Protein of unknown function (DUF3450)

    19. XM_039084000.2 → XP_038939928.1  leucine-rich repeat flightless-interacting protein 1 isoform X48

      UniProtKB/TrEMBL
      A6JQP5
      Conserved Domains (2) summary
      pfam09738
      Location:52 → 384
      LRRFIP; LRRFIP family
      pfam11932
      Location:400 → 459
      DUF3450; Protein of unknown function (DUF3450)

    20. XM_006245464.5 → XP_006245526.1  leucine-rich repeat flightless-interacting protein 1 isoform X41

      See identical proteins and their annotated locations for XP_006245526.1

      UniProtKB/TrEMBL
      A6JQN9, A6JQP5
      Conserved Domains (1) summary
      pfam09738
      Location:52 → 352
      DUF2051; Double stranded RNA binding protein (DUF2051)

    21. XM_039084002.2 → XP_038939930.1  leucine-rich repeat flightless-interacting protein 1 isoform X49

      UniProtKB/TrEMBL
      A6JQP5
      Conserved Domains (2) summary
      pfam09738
      Location:52 → 391
      LRRFIP; LRRFIP family
      pfam11932
      Location:407 → 466
      DUF3450; Protein of unknown function (DUF3450)

    22. XM_039083996.2 → XP_038939924.1  leucine-rich repeat flightless-interacting protein 1 isoform X40

      Conserved Domains (2) summary
      pfam09738
      Location:52 → 360
      LRRFIP; LRRFIP family
      pfam11932
      Location:376 → 435
      DUF3450; Protein of unknown function (DUF3450)

    23. XM_006245465.5 → XP_006245527.1  leucine-rich repeat flightless-interacting protein 1 isoform X44

      See identical proteins and their annotated locations for XP_006245527.1

      UniProtKB/TrEMBL
      A6JQP0, A6JQP5
      Conserved Domains (1) summary
      pfam09738
      Location:52 → 328
      DUF2051; Double stranded RNA binding protein (DUF2051)

    24. XM_006245448.4 → XP_006245510.1  leucine-rich repeat flightless-interacting protein 1 isoform X7

      Conserved Domains (2) summary
      pfam09738
      Location:260 → 541
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl23720
      Location:388 → 456
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    25. XM_006245450.5 → XP_006245512.1  leucine-rich repeat flightless-interacting protein 1 isoform X9

      Related
      ENSRNOP00000077964.2, ENSRNOT00000100450.2
      Conserved Domains (1) summary
      pfam09738
      Location:260 → 510
      DUF2051; Double stranded RNA binding protein (DUF2051)

    26. XM_006245447.4 → XP_006245509.1  leucine-rich repeat flightless-interacting protein 1 isoform X6

      Conserved Domains (2) summary
      pfam09738
      Location:260 → 548
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl12057
      Location:386 → 463
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    27. XM_039083983.1 → XP_038939911.1  leucine-rich repeat flightless-interacting protein 1 isoform X8

      Conserved Domains (1) summary
      pfam09738
      Location:260 → 537
      LRRFIP; LRRFIP family

    28. XM_006245452.5 → XP_006245514.1  leucine-rich repeat flightless-interacting protein 1 isoform X10

      Conserved Domains (1) summary
      pfam09738
      Location:260 → 486
      DUF2051; Double stranded RNA binding protein (DUF2051)

    29. XM_006245446.4 → XP_006245508.1  leucine-rich repeat flightless-interacting protein 1 isoform X4

      Related
      ENSRNOP00000080509.2, ENSRNOT00000100990.2
      Conserved Domains (2) summary
      pfam09738
      Location:245 → 557
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl12057
      Location:395 → 472
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    30. XM_008767285.3 → XP_008765507.1  leucine-rich repeat flightless-interacting protein 1 isoform X3

      Conserved Domains (2) summary
      pfam09738
      Location:247 → 559
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl12057
      Location:397 → 474
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    31. XM_017596579.3 → XP_017452068.1  leucine-rich repeat flightless-interacting protein 1 isoform X11

    32. XM_063267521.1 → XP_063123591.1  leucine-rich repeat flightless-interacting protein 1 isoform X12

    33. XM_006245455.5 → XP_006245517.1  leucine-rich repeat flightless-interacting protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A8L2QNX6
      Conserved Domains (2) summary
      pfam09738
      Location:52 → 374
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl12057
      Location:212 → 289
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    34. XM_063267526.1 → XP_063123596.1  leucine-rich repeat flightless-interacting protein 1 isoform X19

      UniProtKB/TrEMBL
      A0A8L2QNX6

    35. XM_063267522.1 → XP_063123592.1  leucine-rich repeat flightless-interacting protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A8L2QNX6

    36. XM_063267525.1 → XP_063123595.1  leucine-rich repeat flightless-interacting protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A8L2QNX6

    37. XM_063267539.1 → XP_063123609.1  leucine-rich repeat flightless-interacting protein 1 isoform X42

      UniProtKB/TrEMBL
      A6JQP5

    38. XM_039083997.2 → XP_038939925.1  leucine-rich repeat flightless-interacting protein 1 isoform X45

      UniProtKB/TrEMBL
      A6JQP4
      Conserved Domains (2) summary
      pfam09738
      Location:42 → 319
      LRRFIP; LRRFIP family
      pfam11932
      Location:335 → 394
      DUF3450; Protein of unknown function (DUF3450)

    39. XM_006245457.4 → XP_006245519.1  leucine-rich repeat flightless-interacting protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A8I5Y5U1, A0A8L2QNX6
      Related
      ENSRNOP00000076434.1, ENSRNOT00000100660.2
      Conserved Domains (2) summary
      pfam09738
      Location:42 → 340
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl12057
      Location:178 → 255
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    40. XM_063267527.1 → XP_063123597.1  leucine-rich repeat flightless-interacting protein 1 isoform X20

      UniProtKB/TrEMBL
      A0A8L2QNX6

    41. XM_006245445.5 → XP_006245507.1  leucine-rich repeat flightless-interacting protein 1 isoform X2

      Conserved Domains (2) summary
      pfam09738
      Location:250 → 562
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl12057
      Location:400 → 477
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    42. XM_039083982.2 → XP_038939910.1  leucine-rich repeat flightless-interacting protein 1 isoform X5

      Conserved Domains (2) summary
      TIGR02168
      Location:363 → 463
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09738
      Location:237 → 569
      LRRFIP; LRRFIP family

    43. XM_063267529.1 → XP_063123599.1  leucine-rich repeat flightless-interacting protein 1 isoform X24

      UniProtKB/TrEMBL
      A0A8I6A6Y5, A6JQP1
      Related
      ENSRNOP00000088829.1, ENSRNOT00000095067.2

    44. XM_006245461.5 → XP_006245523.1  leucine-rich repeat flightless-interacting protein 1 isoform X27

      UniProtKB/TrEMBL
      A0A8I5Y1S8, A6JQP1
      Conserved Domains (1) summary
      COG1340
      Location:385 → 655
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

    45. XM_039083998.2 → XP_038939926.1  leucine-rich repeat flightless-interacting protein 1 isoform X46

      UniProtKB/TrEMBL
      A6JQP1
      Related
      ENSRNOP00000095213.2, ENSRNOT00000119489.2
      Conserved Domains (2) summary
      pfam09738
      Location:222 → 575
      LRRFIP; LRRFIP family
      pfam11932
      Location:591 → 650
      DUF3450; Protein of unknown function (DUF3450)

    46. XM_006245456.4 → XP_006245518.1  leucine-rich repeat flightless-interacting protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A8L2QNX6
      Conserved Domains (2) summary
      pfam09738
      Location:42 → 364
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl12057
      Location:202 → 279
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    47. XM_063267523.1 → XP_063123593.1  leucine-rich repeat flightless-interacting protein 1 isoform X17

      UniProtKB/TrEMBL
      A0A8I5Y0X7, A0A8L2QNX6
      Related
      ENSRNOP00000076897.1, ENSRNOT00000112051.2

    48. XM_063267528.1 → XP_063123598.1  leucine-rich repeat flightless-interacting protein 1 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZL04, A0A8L2QNX6
      Related
      ENSRNOP00000078450.2, ENSRNOT00000112176.2

    49. XM_063267540.1 → XP_063123610.1  leucine-rich repeat flightless-interacting protein 1 isoform X43

      UniProtKB/TrEMBL
      A6JQP4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HF9.1 GenPept UniProtKB/Swiss-Prot:Q66HF9

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