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    chmp1a charged multivesicular body protein 1A [ Danio rerio (zebrafish) ]

    Gene ID: 393535, updated on 27-Mar-2024

    Summary

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    Official Symbol
    chmp1aprovided by ZNC
    Official Full Name
    charged multivesicular body protein 1Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1474
    See related
    Ensembl:ENSDARG00000102643 AllianceGenome:ZFIN:ZDB-GENE-040426-1474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    KM0004; pcoln3; zgc:65914; zgc:85863; wu:fb50a12
    Summary
    Acts upstream of or within cerebellum development. Predicted to be located in endosome; membrane; and nuclear matrix. Predicted to be part of ESCRT III complex. Predicted to be active in multivesicular body. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 8. Orthologous to human CHMP1A (charged multivesicular body protein 1A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See chmp1a in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (37435324..37442125)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (36864777..36871567)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene CD44 molecule (IN blood group) b Neighboring gene pyruvate dehydrogenase complex component X Neighboring gene Fanconi anemia group A protein-like Neighboring gene solute carrier family 10 member 3 Neighboring gene ribosomal protein L27a Neighboring gene zinc finger protein 276

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. Mochida GH, et al. Nat Genet, 2012 Nov. PMID 23023333, Free PMC Article
    2. Functional validation of CHMP7 as an ADHD risk gene. Dark C, et al. Transl Psychiatry, 2020 Nov 6. PMID 33159045, Free PMC Article
    3. The Fanconi anemia gene network is conserved from zebrafish to human. Titus TA, et al. Gene, 2006 Apr 26. PMID 16515849
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC65914

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cerebellum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    charged multivesicular body protein 1a
    Names
    chromatin modifying protein 1A
    chromatin-modifying protein 1a
    procollagen (type III) N-endopeptidase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200563.3 → NP_956857.1  charged multivesicular body protein 1a

      See identical proteins and their annotated locations for NP_956857.1

      Status: VALIDATED

      Source sequence(s)
      CU633770
      UniProtKB/Swiss-Prot
      Q6NWA3, Q6PHF0
      Conserved Domains (1) summary
      cl21588
      Location:13 → 170
      Snf7; Snf7

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      37435324..37442125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009298223.3 → XP_009296498.1  charged multivesicular body protein 1a isoform X1

      UniProtKB/Swiss-Prot
      Q6PHF0
      Related
      ENSDARP00000141533.2, ENSDART00000164390.2
      Conserved Domains (1) summary
      cl21588
      Location:13 → 170
      Snf7; Snf7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PHF0.1 GenPept UniProtKB/Swiss-Prot:Q6PHF0

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