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    Ak4 adenylate kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29223, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ak4provided by RGD
    Official Full Name
    adenylate kinase 4provided by RGD
    Primary source
    RGD:2078
    See related
    AllianceGenome:RGD:2078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AK 4; Ak3l1; Ak3l2
    Summary
    Predicted to enable adenylate kinase activity; nucleoside diphosphate kinase activity; and nucleoside triphosphate adenylate kinase activity. Involved in liver development and response to xenobiotic stimulus. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Biomarker of acute kidney tubular necrosis. Orthologous to human AK4 (adenylate kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 1264.8), Liver (RPKM 558.2) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ak4 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (121154565..121214403)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (116039222..116099064)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (120250318..120309153)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479017 Neighboring gene ribosomal protein L9, pseudogene 16 Neighboring gene DnaJ heat shock protein family (Hsp40) member C6 Neighboring gene uncharacterized LOC134479018 Neighboring gene uncharacterized LOC120102936

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants. Yamamoto T, et al. J Toxicol Sci, 2006 Feb. PMID 16538043
    2. Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis. Jan YH, et al. J Hematol Oncol, 2019 Jan 29. PMID 30696468, Free PMC Article
    3. Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4. Panayiotou C, et al. Int J Biochem Cell Biol, 2010 Jan. PMID 19766732
    4. Proteomics investigation on aristolochic acid nephropathy: a case study on rat kidney tissues. Wu HZ, et al. Anal Bioanal Chem, 2011 Apr. PMID 21152904
    5. Differential expression of adenylate kinase 4 in the context of disparate stress response strategies of HEK293 and HepG2 cells. Kong F, et al. Arch Biochem Biophys, 2013 May. PMID 23474458

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-124 conducts neuroprotective effect via inhibiting AK4/ATF3 after subarachnoid hemorrhage.
      Title: MicroRNA-124 conducts neuroprotective effect via inhibiting AK4/ATF3 after subarachnoid hemorrhage.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93541

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables (deoxy)adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CMP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables adenylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dCMP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside diphosphate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleoside triphosphate adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables nucleoside triphosphate adenylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside triphosphate adenylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ADP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in AMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in AMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in AMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GTP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of cellular response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in nucleoside monophosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside triphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of oxidative phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in ribonucleoside diphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribonucleoside diphosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenylate kinase 4, mitochondrial
    Names
    ATP-AMP transphosphorylase
    GTP:AMP phosphotransferase AK4, mitochondrial
    adenylate kinase 3 alpha-like 1
    adenylate kinase 3-like 1
    adenylate kinase 3-like 2
    adenylate kinase isoenzyme 4, mitochondrial
    NP_058831.1
    XP_017448685.1
    XP_038965281.1
    XP_063143316.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429545.1 → NP_001416474.1  adenylate kinase 4, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q9WUS0

    2. NM_001429546.1 → NP_001416475.1  adenylate kinase 4, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q9WUS0

    3. NM_001429547.1 → NP_001416476.1  adenylate kinase 4, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JRN4

    4. NM_001429548.1 → NP_001416477.1  adenylate kinase 4, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JRN6

    5. NM_017135.4 → NP_058831.1  adenylate kinase 4, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_058831.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q9WUS0
      UniProtKB/TrEMBL
      A0A8L2QYP3
      Conserved Domains (1) summary
      TIGR01351
      Location:7 → 211
      adk; adenylate kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      121154565..121214403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593196.3 → XP_017448685.1  adenylate kinase 4, mitochondrial isoform X1

      Conserved Domains (1) summary
      TIGR01351
      Location:7 → 211
      adk; adenylate kinase

    2. XM_063287246.1 → XP_063143316.1  adenylate kinase 4, mitochondrial isoform X1

    3. XM_039109353.2 → XP_038965281.1  adenylate kinase 4, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam00406
      Location:1 → 116
      ADK; Adenylate kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUS0.1 GenPept UniProtKB/Swiss-Prot:Q9WUS0

    Gene LinkOut

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