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    fgf13a fibroblast growth factor 13a [ Danio rerio (zebrafish) ]

    Gene ID: 492758, updated on 25-Apr-2024

    Summary

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    Official Symbol
    fgf13aprovided by ZNC
    Official Full Name
    fibroblast growth factor 13aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-101
    See related
    Ensembl:ENSDARG00000035056 AllianceGenome:ZFIN:ZDB-GENE-041114-101
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fgf13; zgc:101784
    Summary
    Predicted to enable sodium channel regulator activity. Predicted to be involved in regulation of voltage-gated sodium channel activity. Predicted to act upstream of or within nervous system development. Predicted to be located in several cellular components, including filopodium; growth cone; and microtubule. Predicted to be active in cytoplasm and nucleus. Is expressed in basal plate midbrain region; heart; myotome; nervous system; and trigeminal placode. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human FGF13 (fibroblast growth factor 13). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See fgf13a in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (32183978..32405269, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (31843673..32064845, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene zic family member 6 Neighboring gene si:ch211-69b22.5 Neighboring gene zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) Neighboring gene uncharacterized LOC103908759 Neighboring gene MCF.2 cell line derived transforming sequence a Neighboring gene coagulation factor IXa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A novel conserved enhancer at zebrafish zic3 and zic6 loci drives neural expression. Minhas R, et al. Dev Dyn, 2019 Sep. PMID 31194899, Free PMC Article
    2. Development of the cardiac conduction system in zebrafish. Poon KL, et al. Gene Expr Patterns, 2016 Jul. PMID 27593944
    3. Genome-wide analysis of Tol2 transposon reintegration in zebrafish. Kondrychyn I, et al. BMC Genomics, 2009 Sep 8. PMID 19737393, Free PMC Article
    4. Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species. Heanue TA, et al. Mech Dev, 2008 Aug. PMID 18565740
    5. Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish. Burczyk MS, et al. JCI Insight, 2019 Oct 17. PMID 31619590, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibroblast growth factor 13; fibroblast growth factor 13a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007399.1 → NP_001007400.1  fibroblast growth factor 13a

      See identical proteins and their annotated locations for NP_001007400.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085439
      UniProtKB/TrEMBL
      B2GRU5, Q5U3Q2
      Related
      ENSDARP00000052948.4, ENSDART00000052949.6
      Conserved Domains (1) summary
      smart00442
      Location:15 → 145
      FGF; Acidic and basic fibroblast growth factor family

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      32183978..32405269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017359008.2 → XP_017214497.1  fibroblast growth factor 13 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z9T8, E7F5G0
      Related
      ENSDARP00000144959.1, ENSDART00000184647.1
      Conserved Domains (1) summary
      smart00442
      Location:77 → 207
      FGF; Acidic and basic fibroblast growth factor family

    2. XM_005173208.4 → XP_005173265.1  fibroblast growth factor 13 isoform X1

      See identical proteins and their annotated locations for XP_005173265.1

      UniProtKB/TrEMBL
      A0A8M6Z9T8, E7F5G0
      Conserved Domains (1) summary
      smart00442
      Location:77 → 207
      FGF; Acidic and basic fibroblast growth factor family

    3. XM_005173209.4 → XP_005173266.1  fibroblast growth factor 13 isoform X1

      See identical proteins and their annotated locations for XP_005173266.1

      UniProtKB/TrEMBL
      A0A8M6Z9T8, E7F5G0
      Related
      ENSDARP00000008134.8, ENSDART00000010982.11
      Conserved Domains (1) summary
      smart00442
      Location:77 → 207
      FGF; Acidic and basic fibroblast growth factor family

    4. XM_021481007.1 → XP_021336682.1  fibroblast growth factor 13 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PZ61
      Related
      ENSDARP00000155917.1, ENSDART00000185594.1
      Conserved Domains (1) summary
      smart00442
      Location:21 → 151
      FGF; Acidic and basic fibroblast growth factor family

    5. XM_005173211.4 → XP_005173268.1  fibroblast growth factor 13 isoform X2

      See identical proteins and their annotated locations for XP_005173268.1

      UniProtKB/TrEMBL
      A0A8M2BKJ8, Q5TKR2
      Related
      ENSDARP00000023323.6, ENSDART00000017259.7
      Conserved Domains (1) summary
      smart00442
      Location:68 → 198
      FGF; Acidic and basic fibroblast growth factor family
    Nucleotide Protein Strain
    Heading Accession and Version

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