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    pof1b POF1B actin binding protein [ Danio rerio (zebrafish) ]

    Gene ID: 564098, updated on 27-Mar-2024

    Summary

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    Official Symbol
    pof1bprovided by ZNC
    Official Full Name
    POF1B actin binding proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4287
    See related
    Ensembl:ENSDARG00000054060 AllianceGenome:ZFIN:ZDB-GENE-030131-4287
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc88b11; wu:fa99b01; wu:fc88b11; si:dkeyp-8h9.2
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization; bicellular tight junction assembly; and epithelial cell morphogenesis. Predicted to be active in actin filament; adherens junction; and bicellular tight junction. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 2B. Orthologous to human POF1B (POF1B actin binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See pof1b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (38513532..38582028, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (38465551..38534322, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene POU class 4 homeobox 4 Neighboring gene protein sprouty homolog 2-like Neighboring gene solute carrier family 25 member 14 Neighboring gene uncharacterized LOC110438246

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain. Huang L, et al. Sci Rep, 2019 Feb 12. PMID 30755680, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bicellular tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein POF1B
    Names
    premature ovarian failure, 1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      38513532..38582028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469233.1 → XP_021324908.1  protein POF1B

      UniProtKB/TrEMBL
      A0A8M9PDM7
      Related
      ENSDARP00000157150.1, ENSDART00000193891.1
      Conserved Domains (1) summary
      cl25732
      Location:212 → 539
      SMC_N; RecF/RecN/SMC N terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395097.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      326168..390105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002666059.6 → XP_002666105.5  protein POF1B

      UniProtKB/TrEMBL
      A0A2R8PYS8, A0A8M1RMM2
      Conserved Domains (1) summary
      cl25732
      Location:212 → 539
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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