pgrmc1 progesterone receptor membrane component 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pgrmc1provided by ZNC
Official Full Name: progesterone receptor membrane component 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-041114-91
See related: Ensembl:ENSDARG00000054172 AllianceGenome:ZFIN:ZDB-GENE-041114-91
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa94d03; wu:fa94d03; wu:fq25e02; zgc:103577
Summary: Predicted to enable metal ion binding activity and steroid binding activity. Acts upstream of or within several processes, including maintenance of lens transparency; oocyte maturation; and response to progesterone. Predicted to be located in endoplasmic reticulum membrane; extracellular region; and mitochondrial outer membrane. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including digestive system; gonad; heart; integument; and muscle. Used to study cataract. Orthologous to human PGRMC1 (progesterone receptor membrane component 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (37436898..37440701)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (37751711..37755514)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In addition to the delayed oocyte maturation and reduced female fertility, significant reduced ovulation was found in double knockout (pgrmc1/2(-/-)) in vivo, though not detected in either single knockout of Pgrmc (pgrmc1(-/-) or pgrmc2(-/-)).
Title: Downregulation of nuclear progestin receptor (Pgr) and subfertility in double knockouts of progestin receptor membrane component 1 (pgrmc1) and pgrmc2 in zebrafish.
These results indicate that maintenance of Pgrmc1 signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper.
Title: Role of Pgrmc1 in estrogen maintenance of meiotic arrest in zebrafish oocytes through Gper/Egfr.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables steroid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within maintenance of lens transparency	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of meiotic cell cycle process involved in oocyte maturation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to progesterone	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: membrane-associated progesterone receptor component 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.