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    dag1 dystroglycan 1 [ Danio rerio (zebrafish) ]

    Gene ID: 286829, updated on 12-Sep-2024

    Summary

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    Official Symbol
    dag1provided by ZNC
    Official Full Name
    dystroglycan 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021223-1
    See related
    Ensembl:ENSDARG00000016153 AllianceGenome:ZFIN:ZDB-GENE-021223-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dag; wu:fb83d06; wu:fi25f06; wu:fi37b08; zgc:109786
    Summary
    Enables laminin binding activity. Acts upstream of or within several processes, including T-tubule organization; skeletal muscle organ development; and somatic muscle development. Located in sarcolemma. Is expressed in several structures, including mesoderm; nervous system; pronephros; somite; and trunk musculature. Used to study muscular dystrophy-dystroglycanopathy. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2D; autosomal recessive limb-girdle muscular dystrophy type 2P; congenital muscular dystrophy-dystroglycanopathy type A9; and inclusion body myositis. Orthologous to human DAG1 (dystroglycan 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See dag1 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (33132024..33194805)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (33177382..33240229)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 15B Neighboring gene poly(rC) binding protein 4 Neighboring gene nicolin 1 Neighboring gene glutamate metabotropic receptor 7 Neighboring gene uncharacterized LOC137488973

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Insights from molecular dynamics simulations: structural basis for the V567D mutation-induced instability of zebrafish alpha-dystroglycan and comparison with the murine model. Pirolli D, et al. PLoS One, 2014. PMID 25078606, Free PMC Article
    2. Duplication of the dystroglycan gene in most branches of teleost fish. Pavoni E, et al. BMC Mol Biol, 2007 May 17. PMID 17509131, Free PMC Article
    3. Characterization of Zebrafish Models of Marinesco-Sjögren Syndrome. Kawahara G, et al. PLoS One, 2016. PMID 27792754, Free PMC Article
    4. Dasatinib as a treatment for Duchenne muscular dystrophy. Lipscomb L, et al. Hum Mol Genet, 2016 Jan 15. PMID 26604135, Free PMC Article
    5. Analysis of skeletal muscle defects in larval zebrafish by birefringence and touch-evoke escape response assays. Smith LL, et al. J Vis Exp, 2013 Dec 13. PMID 24378748, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fkrp plays an early and essential role in muscle, myotendinous junction, and neuromuscular junction development. The data also indicate that, at least in the zebrafish model, FKRP-associated dystroglycanopathy does not exactly phenocopy dystroglycan deficiency.
      Title: NAD+ improves neuromuscular development in a zebrafish model of FKRP-associated dystroglycanopathy.
    2. Patchytail fish contain a point mutation (c.1700T>A) in dag1, resulting in a missense change leading to skeletal muscle defects, brain abnormalities and ocular defects in posterior as well as anterior chambers.
      Title: The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies.
    3. genetic evidence that neuromuscular synapse formation can occur in the absence of MuSK and that the combinatorial function of UnpFL/MuSK and dystroglycan generates diverse patterns of vertebrate neuromuscular innervation
      Title: Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation.
    4. Removal of dystroglycan causes severe muscular dystrophy in zebrafish embryos.
      Title: Removal of dystroglycan causes severe muscular dystrophy in zebrafish embryos.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109786

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables laminin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables laminin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within T-tubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in morphogenesis of an epithelium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle attachment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within muscle attachment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nerve development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within receptor clustering IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dystroglycan complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dystrophin-associated glycoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dystrophin-associated glycoprotein complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dystroglycan 1
    Names
    dystrophin-associated glycoprote
    dystrophin-associated glycoprotein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173274.1 → NP_775381.1  dystroglycan 1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      AF483476
      UniProtKB/TrEMBL
      Q8JHU7
      Related
      ENSDARP00000020759.6, ENSDART00000004504.8
      Conserved Domains (4) summary
      cd11303
      Location:79 → 171
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      cd11305
      Location:192 → 314
      alpha_DG_C; C-terminal domain of alpha dystroglycan
      smart00736
      Location:476 → 570
      CADG; Dystroglycan-type cadherin-like domains
      pfam05454
      Location:580 → 866
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      33132024..33194805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009296487.4 → XP_009294762.1  dystroglycan 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AUX6, F1QMH7
      Conserved Domains (4) summary
      cd11303
      Location:79 → 171
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      cd11305
      Location:192 → 314
      alpha_DG_C; C-terminal domain of alpha dystroglycan
      smart00736
      Location:476 → 570
      CADG; Dystroglycan-type cadherin-like domains
      pfam05454
      Location:580 → 866
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

    2. XM_005170544.5 → XP_005170601.1  dystroglycan 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AUX6, F1QMH7
      Related
      ENSDARP00000106371.1, ENSDART00000126885.3
      Conserved Domains (4) summary
      cd11303
      Location:79 → 171
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      cd11305
      Location:192 → 314
      alpha_DG_C; C-terminal domain of alpha dystroglycan
      smart00736
      Location:476 → 570
      CADG; Dystroglycan-type cadherin-like domains
      pfam05454
      Location:580 → 866
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    Nucleotide Protein Strain
    Heading Accession and Version

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