mxi1 max interactor 1, dimerization protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mxi1provided by ZNC
Official Full Name: max interactor 1, dimerization proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-151
See related: Ensembl:ENSDARG00000040884 AllianceGenome:ZFIN:ZDB-GENE-990415-151
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb16b12; fb55f03; wu:fb16b12; wu:fb55f03; wu:fd06a08; wu:fz74f10; etID309773.22
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including axial chorda mesoderm; median fin fold; nervous system; neural tube; and periderm. Human ortholog(s) of this gene implicated in neurofibrosarcoma and prostate cancer. Orthologous to human MXI1 (MAX interactor 1, dimerization protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (30330563..30358532)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (30381368..30409337)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fd06a08.y1 (e-PCR)
- UniSTS:194978

zmxi1 (e-PCR)
- UniSTS:187072

fb16b12.x1 (e-PCR)
- UniSTS:202962

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: max-interacting protein 1

Names: adducin 3 (gamma); max interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308638.1 → NP_001295567.1 max-interacting protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate first exon in place of the first exon of variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

BX649448, EB839845, EB895068

UniProtKB/Swiss-Prot

P50541

UniProtKB/TrEMBL

A0A8M1P6J8, A3KQG1

Related

ENSDARP00000059922.3, ENSDART00000059923.4

Conserved Domains (1) summary

smart00353
Location:61 → 113

HLH; helix loop helix domain
NM_131237.2 → NP_571312.2 max-interacting protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BX649448, EB895068

UniProtKB/Swiss-Prot

P50541

UniProtKB/TrEMBL

A0A8M1PBL3, A3KQG0

Related

ENSDARP00000095521.4, ENSDART00000104751.6

Conserved Domains (1) summary

smart00353
Location:112 → 164

HLH; helix loop helix domain