prkar1ab protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prkar1abprovided by ZNC
Official Full Name: protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-238
See related: Ensembl:ENSDARG00000101755 AllianceGenome:ZFIN:ZDB-GENE-050417-238
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:112145
Summary: Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Predicted to be involved in negative regulation of cAMP-dependent protein kinase activity. Predicted to act upstream of or within regulation of protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (2870678..2895802)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (2835945..2861069)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cAMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP binding	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A catalytic subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of cAMP-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cAMP-dependent protein kinase complex	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b

NP_001017732.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017732.1 → NP_001017732.1 protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b

See identical proteins and their annotated locations for NP_001017732.1

Status: PROVISIONAL

Source sequence(s)

BC093222

UniProtKB/TrEMBL

Q567D1

Related

ENSDARP00000138282.1, ENSDART00000165225.2

Conserved Domains (3) summary

cd12101
Location:13 → 62

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

COG0664
Location:247 → 357

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:135 → 244

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...