U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    chac1 ChaC, cation transport regulator homolog 1 (E. coli) [ Danio rerio (zebrafish) ]

    Gene ID: 563855, updated on 12-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    chac1provided by ZNC
    Official Full Name
    ChaC, cation transport regulator homolog 1 (E. coli)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1957
    See related
    Ensembl:ENSDARG00000070426 AllianceGenome:ZFIN:ZDB-GENE-030131-1957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb1014; wu:fb93a10; wu:fp64e03
    Summary
    Predicted to enable Notch binding activity and gamma-glutamylcyclotransferase activity. Acts upstream of or within with a positive effect on glutathione catabolic process. Predicted to be located in trans-Golgi network. Predicted to be active in cytoplasm. Is expressed in several structures, including alar plate midbrain region; nervous system; optic vesicle; periderm; and solid lens vesicle. Orthologous to human CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See chac1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (28266935..28269464)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (28367845..28370374)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene synapse differentiation inducing 1-like Neighboring gene delta-like 4 (Drosophila) Neighboring gene INO80 complex ATPase subunit Neighboring gene VPS18 core subunit of CORVET and HOPS complexes

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The glutathione degrading enzyme, Chac1, is required for calcium signaling in developing zebrafish: redox as an upstream activator of calcium. Yadav S, et al. Biochem J, 2019 Jul 2. PMID 31189567
    2. Chronic cortisol exposure in early development leads to neuroendocrine dysregulation in adulthood. Hartig EI, et al. BMC Res Notes, 2020 Aug 3. PMID 32746894, Free PMC Article
    3. Expression profiling and comparative genomics identify a conserved regulatory region controlling midline expression in the zebrafish embryo. Dickmeis T, et al. Genome Res, 2004 Feb. PMID 14718378, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The study thus identifies Chac1 and the consequent change in intracellular glutathione redox potential as important upstream activators of calcium signaling during development.
      Title: The glutathione degrading enzyme, Chac1, is required for calcium signaling in developing zebrafish: redox as an upstream activator of calcium.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC4504, MGC173477, MGC173478

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Notch binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione specific gamma-glutamylcyclotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione specific gamma-glutamylcyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within_positive_effect glutathione catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glutathione catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_positive_effect glutathione catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of protein processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    glutathione-specific gamma-glutamylcyclotransferase 1
    Names
    ChaC, cation transport regulator-like 1
    cation transport regulator-like protein 1
    gamma-GCG 1
    NP_001103596.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110126.2 → NP_001103596.2  glutathione-specific gamma-glutamylcyclotransferase 1

      See identical proteins and their annotated locations for NP_001103596.2

      Status: VALIDATED

      Source sequence(s)
      BC153392, CK400274
      UniProtKB/Swiss-Prot
      Q5SPB6
      UniProtKB/TrEMBL
      A4QNY6
      Related
      ENSDARP00000094107.4, ENSDART00000103330.5
      Conserved Domains (2) summary
      COG3703
      Location:5 → 190
      ChaC; Cation transport regulator ChaC [Inorganic ion transport and metabolism]
      pfam04752
      Location:13 → 183
      ChaC; ChaC-like protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      28266935..28269464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SPB6.1 GenPept UniProtKB/Swiss-Prot:Q5SPB6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous