glrx5 glutaredoxin 5 homolog (S. cerevisiae) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: glrx5provided by ZNC
Official Full Name: glutaredoxin 5 homolog (S. cerevisiae)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1957
See related: Ensembl:ENSDARG00000043665 AllianceGenome:ZFIN:ZDB-GENE-040426-1957
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: grx5; zgc:73343; id:ibd5119; wu:fa09g08
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity; metal ion binding activity; and protein-disulfide reductase activity. Acts upstream of or within hemopoiesis and iron-sulfur cluster assembly. Located in mitochondrion. Is expressed in cardiovascular system; immature eye; intermediate cell mass of mesoderm; and liver. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 3. Orthologous to human GLRX5 (glutaredoxin 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (10484017..10487887, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (10496777..10500647, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the hypochromic anaemia in shiraz (sir) zebrafish mutants is caused by deficiency of glutaredoxin 5 (grx5), a gene required in yeast for Fe-S cluster assembly
Title: Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis.

Submit: New GeneRIF Correction

General gene information

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Markers

fa09g08.s1 (e-PCR)
- UniSTS:202266

fb40a05 (e-PCR)
- UniSTS:187189

AA495459 (e-PCR)
- UniSTS:206946

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within iron-sulfur cluster assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutaredoxin-related protein 5, mitochondrial

Names: monothiol glutaredoxin-5; shiraz; shz

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213021.1 → NP_998186.1 glutaredoxin-related protein 5, mitochondrial

See identical proteins and their annotated locations for NP_998186.1

Status: PROVISIONAL

Source sequence(s)

BC059659

UniProtKB/Swiss-Prot

Q6PBM1

Related

ENSDARP00000064111.4, ENSDART00000064112.5

Conserved Domains (1) summary

cd03028
Location:45 → 135

GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...