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    anapc1 anaphase promoting complex subunit 1 [ Danio rerio (zebrafish) ]

    Gene ID: 568795, updated on 27-Mar-2024

    Summary

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    Official Symbol
    anapc1provided by ZNC
    Official Full Name
    anaphase promoting complex subunit 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081107-12
    See related
    Ensembl:ENSDARG00000075687 AllianceGenome:ZFIN:ZDB-GENE-081107-12
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-160m22.1
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; metaphase/anaphase transition of mitotic cell cycle; and protein K11-linked ubiquitination. Predicted to act upstream of or within cell division. Predicted to be part of anaphase-promoting complex. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human ANAPC1 (anaphase promoting complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See anapc1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (47007114..47175666)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (46717291..46885829)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene F-box protein 5 Neighboring gene vasoactive intestinal peptide Neighboring gene BCL2 like 11 Neighboring gene acyl-CoA oxidase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of candidate genes in 2q13 deletion syndrome implicates FBLN7 and TMEM87B deficiency in congenital heart defects and FBLN7 in craniofacial malformations. Russell MW, et al. Hum Mol Genet, 2014 Aug 15. PMID 24694933
    2. Genetic landscape of T cells identifies synthetic lethality for T-ALL. O'Meara CP, et al. Commun Biol, 2021 Oct 20. PMID 34671088, Free PMC Article
    3. The CCCH-type zinc finger transcription factor Zc3h8 represses NF-κB-mediated inflammation in digestive organs in zebrafish. Zou Q, et al. J Biol Chem, 2018 Aug 3. PMID 29871925, Free PMC Article
    4. Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Rossmann MP, et al. Science, 2021 May 14. PMID 33986176, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metaphase/anaphase transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      47007114..47175666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157066.3 → XP_005157123.1  anaphase-promoting complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8QA59, A0A8M2B392
      Related
      ENSDARP00000150216.1, ENSDART00000183205.1
      Conserved Domains (1) summary
      pfam12859
      Location:147 → 199
      ANAPC1; Anaphase-promoting complex subunit 1

    2. XM_005157067.3 → XP_005157124.1  anaphase-promoting complex subunit 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B3F5
      Conserved Domains (1) summary
      pfam12859
      Location:147 → 199
      ANAPC1; Anaphase-promoting complex subunit 1

    3. XM_001921133.4 → XP_001921168.2  anaphase-promoting complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M1QKJ8
      Conserved Domains (1) summary
      pfam12859
      Location:147 → 205
      ANAPC1; Anaphase-promoting complex subunit 1

    4. XM_021480904.1 → XP_021336579.1  anaphase-promoting complex subunit 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9QG54
      Conserved Domains (1) summary
      pfam12859
      Location:147 → 187
      ANAPC1; Anaphase-promoting complex subunit 1
    Nucleotide Protein Strain
    Heading Accession and Version

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