veph1 ventricular zone expressed PH domain-containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: veph1provided by ZNC
Official Full Name: ventricular zone expressed PH domain-containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-041014-375
See related: Ensembl:ENSDARG00000031095 AllianceGenome:ZFIN:ZDB-GENE-041014-375
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: veph; zVeph-A
Summary: Predicted to enable phosphatidylinositol-5-phosphate binding activity. Acts upstream of or within brain development and ear morphogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; hindbrain; midbrain; otic vesicle; and ventricular zone. Orthologous to human VEPH1 (ventricular zone expressed PH domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 18

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (41314004..41465606)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (41323812..41475414)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Blockage of zVeph expression resulted in a defect in the midbrain-hindbrain boundary and otic vesicle formation, suggesting the important function of zVeph in central nervous system (CNS) development
Title: Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fb04g11.y1 (e-PCR)
- UniSTS:189871

fb05a06.x1 (e-PCR)
- UniSTS:202688

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatidylinositol-5-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: ventricular zone-expressed PH domain-containing protein

Names: protein melted homolog; ventricular zone expressed PH domain protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212831.1 → NP_997996.1 ventricular zone-expressed PH domain-containing protein

See identical proteins and their annotated locations for NP_997996.1

Status: PROVISIONAL

Source sequence(s)

AB085188

UniProtKB/Swiss-Prot

A2BID5, A4IG20, Q8JIG6

UniProtKB/TrEMBL

A0A0R4I9B9

Related

ENSDARP00000048984.7, ENSDART00000048985.8

Conserved Domains (2) summary

cd01264
Location:696 → 804

PH_MELT_VEPH1; Melted pleckstrin homology (PH) domain

pfam00169
Location:697 → 799

PH; PH domain