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    kpa1 DinB-like DNA repair polymerase kappa [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539547, updated on 22-Jun-2024

    Summary

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    Gene symbol
    kpa1
    Gene description
    DinB-like DNA repair polymerase kappa
    Locus tag
    SPOM_SPCC553.07C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    dinb; mug40; pol(kappa); pol-kappa
    Old locus tag
    SPCC553.07c
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    Genomic context

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    See kpa1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003421.2 (293376..295247)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA polymerase alpha B-subunit Neighboring gene ncRNA Neighboring gene GTPase Ria1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene oligosaccharyltransferase delta subunit Swp1 Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Postreplication gaps at UV lesions are signals for checkpoint activation. Callegari AJ, et al. Proc Natl Acad Sci U S A, 2010 May 4. PMID 20404181, Free PMC Article
    2. Rad8Rad5/Mms2-Ubc13 ubiquitin ligase complex controls translesion synthesis in fission yeast. Coulon S, et al. EMBO J, 2010 Jun 16. PMID 20453833, Free PMC Article
    3. Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication. Soriano I, et al. PLoS Genet, 2021 Jul. PMID 34228709, Free PMC Article
    4. Checkpoint activation regulates mutagenic translesion synthesis. Kai M, et al. Genes Dev, 2003 Jan 1. PMID 12514100, Free PMC Article
    5. Brc1-mediated DNA repair and damage tolerance. Sheedy DM, et al. Genetics, 2005 Oct. PMID 15972456, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in error-free translesion synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translesion synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DinB-like DNA repair polymerase kappa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      293376..295247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022760.3 → NP_587767.2  DinB-like DNA repair polymerase kappa [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587767.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74944
      Conserved Domains (2) summary
      cd03586
      Location:133 → 471
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG0389
      Location:130 → 474
      DinP; Nucleotidyltransferase/DNA polymerase involved in DNA repair [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version

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