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    UME1 Ume1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855964, updated on 7-Jul-2024

    Summary

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    Gene symbol
    UME1
    Gene description
    Ume1p
    Primary source
    FungiDB:YPL139C
    Locus tag
    YPL139C
    See related
    SGD:S000006060; AllianceGenome:SGD:S000006060; VEuPathDB:YPL139C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    WTM3
    Summary
    Enables transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase I; positive regulation of transcription by RNA polymerase II; and regulation of meiotic nuclear division. Located in cytoplasm and nucleus. Part of Rpd3L complex and Rpd3S/Clr6-CII complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See UME1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (289669..291051, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene protein kinase FRK1 Neighboring gene putative mitogen-activated protein kinase kinase MKK2 Neighboring gene Spp1p Neighboring gene protein phosphatase regulator GIP3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Local statistics allow quantification of cell-to-cell variability from high-throughput microscope images. Handfield LF, et al. Bioinformatics, 2015 Mar 15. PMID 25398614, Free PMC Article
    2. Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing. Pemberton LF, et al. Mol Cell Biol, 1997 Aug. PMID 9234739, Free PMC Article
    3. Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast. Strich R, et al. Proc Natl Acad Sci U S A, 1989 Dec. PMID 2690066, Free PMC Article
    4. Ume1p represses meiotic gene transcription in Saccharomyces cerevisiae through interaction with the histone deacetylase Rpd3p. Mallory MJ, et al. J Biol Chem, 2003 Nov 7. PMID 12954623
    5. Homodimeric PHD Domain-containing Rco1 Subunit Constitutes a Critical Interaction Hub within the Rpd3S Histone Deacetylase Complex. Ruan C, et al. J Biol Chem, 2016 Mar 4. PMID 26747610, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Rpd3L complex HDA PubMed 
    part_of Rpd3L complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rpd3L complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rpd3L-Expanded complex HDA PubMed 
    part_of Rpd3L-Expanded complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rpd3S complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ume1p
    NP_015186.1
    • Component of both the Rpd3S and Rpd3L histone deacetylase complexes; negative regulator of meiosis; required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p; UME1 has a paralog, WTM2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      289669..291051 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183953.1 → NP_015186.1  TPA: Ume1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015186.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3M9, P87330, Q03010
      UniProtKB/TrEMBL
      A0A8H4F6Q9, A6ZWB4, B3LKT7, B5VT27, C7GJ91, C8ZIP0, N1NVV2
      Conserved Domains (2) summary
      COG2319
      Location:1 → 445
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:243 → 274
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03010.1

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