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    GPRASP1 G protein-coupled receptor associated sorting protein 1 [ Homo sapiens (human) ]

    Gene ID: 9737, updated on 28-Oct-2024

    Summary

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    Official Symbol
    GPRASP1provided by HGNC
    Official Full Name
    G protein-coupled receptor associated sorting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:24834
    See related
    Ensembl:ENSG00000198932 MIM:300417; AllianceGenome:HGNC:24834
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GASP; GASP1; GASP-1
    Summary
    This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]
    Expression
    Broad expression in brain (RPKM 27.6), ovary (RPKM 20.3) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPRASP1 in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (102651483..102659083)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (101096438..101104038)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101906411..101914011)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ARMCX5-GPRASP2 readthrough Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:101854489-101855260 Neighboring gene armadillo repeat containing X-linked 5 Neighboring gene H3 histone pseudogene 45 Neighboring gene RNA, U6 small nuclear 589, pseudogene Neighboring gene BEN domain containing 7 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GPRASP1 is a candidate anti-oncogene and correlates with immune microenvironment and immunotherapeutic efficiency in head and neck cancer. Zhang T, et al. J Oral Pathol Med, 2023 Mar. PMID 36264603
    2. Identification and biological significance of G protein-coupled receptor associated sorting proteins (GASPs). Abu-Helo A, et al. Pharmacol Ther, 2010 Jun. PMID 20394773
    3. Ligand-induced down-regulation of the cannabinoid 1 receptor is mediated by the G-protein-coupled receptor-associated sorting protein GASP1. Martini L, et al. FASEB J, 2007 Mar. PMID 17197383
    4. G-protein coupled receptor-associated sorting protein 1 (GASP-1), a potential biomarker in breast cancer. Tuszynski GP, et al. Exp Mol Pathol, 2011 Oct. PMID 21791203
    5. G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker. Zheng X, et al. Exp Mol Pathol, 2012 Aug. PMID 22483848

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPRASP1 is a candidate anti-oncogene and correlates with immune microenvironment and immunotherapeutic efficiency in head and neck cancer.
      Title: GPRASP1 is a candidate anti-oncogene and correlates with immune microenvironment and immunotherapeutic efficiency in head and neck cancer.
    2. Comprehensive pan-cancer analysis of role of GPRASP1, associated with clinical outcomes, immune microenvironment, and immunotherapeutic efficiency in pancreatic cancer.
      Title: Comprehensive pan-cancer analysis of role of GPRASP1, associated with clinical outcomes, immune microenvironment, and immunotherapeutic efficiency in pancreatic cancer.
    3. G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker, promotes proliferation and invasion of triple negative breast cancer.
      Title: G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker, promotes proliferation and invasion of triple negative breast cancer.
    4. Study demonstrated that binding of clozapine or olanzapine to the 5-HT7 receptor leads to antagonist-mediated lysosomal degradation by exposing key residues in the C-terminal tail that interact with GASP-1
      Title: Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1.
    5. Data suggest that specific serine/threonine residues in DRD2 (dopamine receptor D2) are involved in regulation of DRD2 endocytosis by GRK2 (G-protein coupled receptor kinase 2) and GASP1.
      Title: ARF6 and GASP-1 are post-endocytic sorting proteins selectively involved in the intracellular trafficking of dopamine D₂ receptors mediated by GRK and PKC in transfected cells.
    6. GASP1 was identified as a potential new serum and biomarker for brain, pancreatic, lung, and breast cancers, and gliomas.
      Title: G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker.
    7. GASP-1 is a key regulator of the trafficking and, by extension, functional expression of GPR55
      Title: The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55.
    8. LIR was able to induce gains in 1RM and quadriceps CSA similar to those observed after traditional HI. These responses may be related to the concomitant decrease in MSTN and increase in FLST isoforms, GASP-1, and SMAD-7 mRNA gene expression.
      Title: Strength training with blood flow restriction diminishes myostatin gene expression.
    9. These studies identify GASP-1 as a potential new serum and tumor biomarker for breast cancer.
      Title: G-protein coupled receptor-associated sorting protein 1 (GASP-1), a potential biomarker in breast cancer.
    10. following this endocytosis the D(3) dopamine receptors fail to recycle and are instead targeted for degradation through an interaction with the G protein-coupled receptor (GPCR)-associated sorting protein-1 (GASP-1)
      Title: Dopamine D(3) receptors are down-regulated following heterologous endocytosis by a specific interaction with G protein-coupled receptor-associated sorting protein-1.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Readthrough ARMCX5-GPRASP2

    Readthrough gene: ARMCX5-GPRASP2, Included gene: ARMCX5, Included gene: GPRASP3, Included gene: GPRASP2, Included gene: LINC00630

    Homology

    Clone Names

    • KIAA0443

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within G protein-coupled receptor catabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in endosome to lysosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor-associated sorting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021332.1 RefSeqGene

      Range
      5118..12718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001099410.2 → NP_001092880.1  G-protein coupled receptor-associated sorting protein 1

      See identical proteins and their annotated locations for NP_001092880.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR and encodes the same protein, as compared to variant 1.
      Source sequence(s)
      AW293629, AY044233, BC114552, DA104338
      Consensus CDS
      CCDS35352.1
      UniProtKB/Swiss-Prot
      O43168, Q5JY77, Q96LA1
      Related
      ENSP00000393691.1, ENST00000415986.5
      Conserved Domains (1) summary
      pfam04826
      Location:1167 → 1390
      Arm_2; Armadillo-like

    2. NM_001099411.2 → NP_001092881.1  G-protein coupled receptor-associated sorting protein 1

      See identical proteins and their annotated locations for NP_001092881.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two exons in the 5' UTR and encodes the same protein, as compared to variant 1.
      Source sequence(s)
      AW293629, AY044233, BC114552, DA094297
      Consensus CDS
      CCDS35352.1
      UniProtKB/Swiss-Prot
      O43168, Q5JY77, Q96LA1
      Related
      ENSP00000409420.1, ENST00000444152.5
      Conserved Domains (1) summary
      pfam04826
      Location:1167 → 1390
      Arm_2; Armadillo-like

    3. NM_001184727.2 → NP_001171656.1  G-protein coupled receptor-associated sorting protein 1

      See identical proteins and their annotated locations for NP_001171656.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an additional exon in the 5' UTR and encodes the same protein, as compared to variant 1.
      Source sequence(s)
      AW293629, AY044233, BC114552, BX489726, BX954816
      Consensus CDS
      CCDS35352.1
      UniProtKB/Swiss-Prot
      O43168, Q5JY77, Q96LA1
      Related
      ENSP00000445683.1, ENST00000537097.2
      Conserved Domains (1) summary
      pfam04826
      Location:1167 → 1390
      Arm_2; Armadillo-like

    4. NM_014710.5 → NP_055525.3  G-protein coupled receptor-associated sorting protein 1

      See identical proteins and their annotated locations for NP_055525.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents a dominant transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AW293629, AY044233, BC114552, DA222893
      Consensus CDS
      CCDS35352.1
      UniProtKB/Swiss-Prot
      O43168, Q5JY77, Q96LA1
      Related
      ENSP00000355146.4, ENST00000361600.9
      Conserved Domains (1) summary
      pfam04826
      Location:1167 → 1390
      Arm_2; Armadillo-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      102651483..102659083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      101096438..101104038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JY77.3 GenPept UniProtKB/Swiss-Prot:Q5JY77

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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