ATF2 activating transcription factor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ATF2provided by HGNC
Official Full Name: activating transcription factor 2provided by HGNC
Primary source: HGNC:HGNC:784
See related: Ensembl:ENSG00000115966 MIM:123811; AllianceGenome:HGNC:784
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HB16; CREB2; TREB7; CREB-2; CRE-BP1
Summary: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]
Expression: Ubiquitous expression in thyroid (RPKM 19.6), brain (RPKM 14.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q31.1

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (175072259..175168203, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (175561049..175656993, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (175936987..176032931, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFbeta2-Smad2/3 signaling pathway in cervical cancer.
Title: MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer.
Human umbilical cord mesenchymal stem cell-derived exosomes loaded miR-451a targets ATF2 to improve rheumatoid arthritis.
Title: Human umbilical cord mesenchymal stem cell-derived exosomes loaded miR-451a targets ATF2 to improve rheumatoid arthritis.
The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer.
Title: The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer.
USP14 Regulates ATF2/PIK3CD Axis to Promote Microvascular Endothelial Cell Proliferation, Migration, and Angiogenesis in Diabetic Retinopathy.
Title: USP14 Regulates ATF2/PIK3CD Axis to Promote Microvascular Endothelial Cell Proliferation, Migration, and Angiogenesis in Diabetic Retinopathy.
Analysis of the interaction of a non-canonical twin half-site of Cyclic AMP-Response Element (CRE) with CRE-binding protein.
Title: Analysis of the interaction of a non-canonical twin half-site of Cyclic AMP-Response Element (CRE) with CRE-binding protein.
The transcription factor ATF2 promotes gastric cancer progression by activating the METTL3/cyclin D1 pathway.
Title: The transcription factor ATF2 promotes gastric cancer progression by activating the METTL3/cyclin D1 pathway.
ATF2 orchestrates macrophage differentiation and activation to promote antibacterial responses.
Title: ATF2 orchestrates macrophage differentiation and activation to promote antibacterial responses.
ATF2 loss promotes 5-FU resistance in colon cancer cells via activation of the ATR-Chk1 damage response pathway.
Title: ATF2 loss promotes 5-FU resistance in colon cancer cells via activation of the ATR-Chk1 damage response pathway.
Activating transcription factor-2 supports the antioxidant capacity and ability of human mesenchymal stem cells to prevent asthmatic airway inflammation.
Title: Activating transcription factor-2 supports the antioxidant capacity and ability of human mesenchymal stem cells to prevent asthmatic airway inflammation.
Increased ATF2 expression predicts poor prognosis and inhibits sorafenib-induced ferroptosis in gastric cancer.
Title: Increased ATF2 expression predicts poor prognosis and inhibits sorafenib-induced ferroptosis in gastric cancer.

Submit: New GeneRIF Correction See all GeneRIFs (136)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 and p300 synergistically increase TGF-beta, ATF-2 and activating protein-1 (AP-1) expression leading to tubular cell apoptosis; in addition, HIV-1 gp120 treatment causes phosphorylation of Smad2 and downregulation of c-Jun	PubMed
Nef	nef	ATF2 mRNA is selectively retained in HIV-1 Nef-expressing cellular exosomes, and three miRNAs (miR-17, miR-92a, and miR-21) which target ATF2 mRNA are selectively secreted in exosomes from these cells	PubMed
	nef	Nef inhibits ASK1/p38MAPK-dependent Mycobacterium tuberculosis-induced TNF-alpha production by inhibiting binding of ATF2 to the TNF-alpha promoter	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80902 (e-PCR)
- UniSTS:87830

SHGC-33561 (e-PCR)
- UniSTS:4379

SHGC-31988 (e-PCR)
- UniSTS:78913

NoName (e-PCR)
- UniSTS:495170

WI-18856 (e-PCR)
- UniSTS:53592

RH80244 (e-PCR)
- UniSTS:86372

ATF2_7769 (e-PCR)
- UniSTS:466101

SGC38090 (e-PCR)
- UniSTS:31202

NoName (e-PCR)
- UniSTS:489708

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IC Inferred by Curator more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cAMP response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP response element binding	IDA Inferred from Direct Assay more info	PubMed
enables cAMP response element binding protein binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H2B acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	TAS Traceable Author Statement more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables leucine zipper domain binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in NK T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in abducens nucleus development	IEA Inferred from Electronic Annotation more info
involved_in adipose tissue development	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process involved in development	IEA Inferred from Electronic Annotation more info
involved_in brainstem development	IEA Inferred from Electronic Annotation more info
involved_in cellular response to anisomycin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leucine starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	IEA Inferred from Electronic Annotation more info
involved_in detection of cell density	IEA Inferred from Electronic Annotation more info
involved_in facial nucleus development	IEA Inferred from Electronic Annotation more info
involved_in growth plate cartilage chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in growth plate cartilage chondrocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in hypoglossal nucleus development	IEA Inferred from Electronic Annotation more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in mitotic intra-S DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	EXP Inferred from Experiment more info	PubMed
involved_in neurofilament cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle myoblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transforming growth factor beta2 production	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in vacuole organization	IEA Inferred from Electronic Annotation more info
involved_in white fat cell differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of H4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II transcription regulator complex	EXP Inferred from Experiment more info	PubMed
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	EXP Inferred from Experiment more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in site of double-strand break	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cyclic AMP-dependent transcription factor ATF-2

Names: cAMP response element-binding protein CRE-BP1; cAMP responsive element binding protein 2, formerly; cAMP-dependent transcription factor ATF-2; cyclic AMP-responsive element-binding protein 2; histone acetyltransferase ATF2

NP_001243019.1

EC 2.3.1.48

NP_001243020.1

EC 2.3.1.48

NP_001243021.1

EC 2.3.1.48

NP_001243022.1

EC 2.3.1.48

NP_001243023.1

EC 2.3.1.48

NP_001871.2

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047045.1 RefSeqGene

Range

5004..100948

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001256090.2 → NP_001243019.1 cyclic AMP-dependent transcription factor ATF-2 isoform 1

See identical proteins and their annotated locations for NP_001243019.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an additional 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

BC107698, BC130335, BX648469, DA995464, DQ003041

Consensus CDS

CCDS2262.1

UniProtKB/Swiss-Prot

A1L3Z2, A4D7U4, A4D7U5, A4D7V1, D3DPE9, G8JLM5, P15336, Q13000, Q3B7B7, Q4ZFU9, Q53RY2, Q8TAR1, Q96JT8

UniProtKB/TrEMBL

B3KY57

Related

ENSP00000376327.1, ENST00000392544.5

Conserved Domains (4) summary

cd12192
Location:65 → 102

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:354 → 414

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:27 → 49

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam05109
Location:90 → 342

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
NM_001256091.2 → NP_001243020.1 cyclic AMP-dependent transcription factor ATF-2 isoform 2

See identical proteins and their annotated locations for NP_001243020.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an additional 5' non-coding exon, and lacks another exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (2) with a shorter N-terminus compared to isoform 1.

Source sequence(s)

BC107698, BC130335, BX648469, DA995464, DQ003049

Consensus CDS

CCDS58738.1

UniProtKB/TrEMBL

B3KY57

Related

ENSP00000407911.3, ENST00000426833.7

Conserved Domains (4) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:336 → 396

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]

cl26386
Location:184 → 312

DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
NM_001256092.2 → NP_001243021.1 cyclic AMP-dependent transcription factor ATF-2 isoform 3

See identical proteins and their annotated locations for NP_001243021.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an internal exon compared to variant 1. This results in translation initiation from another start site, and a shorter isoform (3) with a distinct N-terminus compared to isoform 1.

Source sequence(s)

BC107698, BX648469, DA995464

Consensus CDS

CCDS58737.1

UniProtKB/TrEMBL

B3KY57

Related

ENSP00000340576.5, ENST00000345739.9

Conserved Domains (3) summary

cd12192
Location:9 → 44

GCN4_cent; GCN4 central activation domain-like acidic activation domain

PRK14951
Location:144 → 272

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd14687
Location:296 → 356

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
NM_001256093.2 → NP_001243022.1 cyclic AMP-dependent transcription factor ATF-2 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an internal exon, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in translation initiation from another start site, and a shorter isoform (4) with distinct N- and C- termini compared to isoform 1.

Source sequence(s)

BC107698, BX648469, DA995464, DQ003048

UniProtKB/TrEMBL

A4D7V5

Conserved Domains (2) summary

cd12192
Location:9 → 44

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:296 → 356

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
NM_001256094.2 → NP_001243023.1 cyclic AMP-dependent transcription factor ATF-2 isoform 5

See identical proteins and their annotated locations for NP_001243023.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks several exons from the 3' end, and has a different 3' UTR compared to variant 1. This results in an isoform (5) with a shorter C-terminus compared to isoform 1.

Source sequence(s)

AC007435, BC026175, DA995464

Consensus CDS

CCDS58739.1

UniProtKB/TrEMBL

E9PEK8

Related

ENSP00000386526.1, ENST00000409833.5

Conserved Domains (2) summary

cd12192
Location:65 → 102

GCN4_cent; GCN4 central activation domain-like acidic activation domain

sd00019
Location:27 → 49

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001880.4 → NP_001871.2 cyclic AMP-dependent transcription factor ATF-2 isoform 1

See identical proteins and their annotated locations for NP_001871.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform.

Source sequence(s)

BC107698, BC130335, BX648469, DA995464

Consensus CDS

CCDS2262.1

UniProtKB/Swiss-Prot

A1L3Z2, A4D7U4, A4D7U5, A4D7V1, D3DPE9, G8JLM5, P15336, Q13000, Q3B7B7, Q4ZFU9, Q53RY2, Q8TAR1, Q96JT8

UniProtKB/TrEMBL

B3KY57

Related

ENSP00000264110.2, ENST00000264110.7

Conserved Domains (4) summary

cd12192
Location:65 → 102

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:354 → 414

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:27 → 49

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam05109
Location:90 → 342

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RNA

NR_045768.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (7) contains two additional exons compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC107698, BC130335, BX648469, DA995464, DQ003043
NR_045769.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (8) contains two additional exons, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC107698, BC130335, BX648469, DA995464, DQ003036
NR_045770.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (9) contains two additional exons, and lacks another exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC107698, BX648469, DA995464, DQ003044
NR_045771.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (10) contains an additional exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC107698, BC130335, BX648469, DA995464, DQ003039
NR_045772.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (11) contains two additional exons, and lacks another exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC107698, BC130335, BX648469, DA995464, DQ003040
NR_045773.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (12) contains an additional exon, and lacks another exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC107698, BC130335, BX648469, DA995464, DQ003046
NR_045774.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (13) lacks an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC107698, BX648469, DA995464, DQ003047

Related

ENST00000409437.5