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    S1PR1 sphingosine-1-phosphate receptor 1 [ Homo sapiens (human) ]

    Gene ID: 1901, updated on 28-Oct-2024

    Summary

    Official Symbol
    S1PR1provided by HGNC
    Official Full Name
    sphingosine-1-phosphate receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:3165
    See related
    Ensembl:ENSG00000170989 MIM:601974; AllianceGenome:HGNC:3165
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362
    Summary
    The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
    Expression
    Broad expression in fat (RPKM 52.5), lung (RPKM 39.5) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See S1PR1 in Genome Data Viewer
    Location:
    1p21.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (101236899..101242313)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (101085760..101091176)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (101702455..101707869)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1395 Neighboring gene S1PR1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1396 Neighboring gene MPRA-validated peak339 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1397 Neighboring gene ribosomal protein S20 pseudogene 6 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:101724915-101726114 Neighboring gene peptidylprolyl isomerase A pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of sphingosine-1-phosphate receptor 1 (S1PR1) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ58121

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables G protein-coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sphingolipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sphingosine-1-phosphate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sphingosine-1-phosphate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in T cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in blood vessel maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle tissue growth involved in heart morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endothelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heart trabecula morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lamellipodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in leukocyte chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of bone resorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sphingosine-1-phosphate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sphingosine-1-phosphate receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transmission of nerve impulse IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sphingosine 1-phosphate receptor 1
    Names
    S1P receptor 1
    S1P receptor Edg-1
    endothelial differentiation G-protein coupled receptor 1
    endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
    sphingosine 1-phosphate receptor EDG1
    sphingosine 1-phosphate receptor Edg-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016181.1 RefSeqGene

      Range
      5271..9770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001320730.2NP_001307659.1  sphingosine 1-phosphate receptor 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL109741, BP236900
      Consensus CDS
      CCDS777.1
      UniProtKB/Swiss-Prot
      D3DT66, P21453, Q9BYY4, Q9NYN8
      UniProtKB/TrEMBL
      Q7L853
      Conserved Domains (1) summary
      cd15346
      Location:46322
      7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001400.5NP_001391.2  sphingosine 1-phosphate receptor 1

      See identical proteins and their annotated locations for NP_001391.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL109741
      Consensus CDS
      CCDS777.1
      UniProtKB/Swiss-Prot
      D3DT66, P21453, Q9BYY4, Q9NYN8
      UniProtKB/TrEMBL
      Q7L853
      Related
      ENSP00000305416.6, ENST00000305352.7
      Conserved Domains (1) summary
      cd15346
      Location:46322
      7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors

    RNA

    1. NR_174345.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL109741
    2. NR_174346.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL109741
    3. NR_174347.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL109741
    4. NR_174348.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL109741
    5. NR_174349.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL109741
    6. NR_174350.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL109741

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      101236899..101242313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007095678.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      101085760..101091176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008485945.1 RNA Sequence