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    NOL6 nucleolar protein 6 [ Homo sapiens (human) ]

    Gene ID: 65083, updated on 3-Nov-2024

    Summary

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    Official Symbol
    NOL6provided by HGNC
    Official Full Name
    nucleolar protein 6provided by HGNC
    Primary source
    HGNC:HGNC:19910
    See related
    Ensembl:ENSG00000165271 MIM:611532; AllianceGenome:HGNC:19910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NRAP; UTP22; bA311H10.1
    Summary
    The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 9.6), skin (RPKM 6.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NOL6 in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (33461353..33473924, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (33479851..33492421, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33461351..33473922, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene aquaporin 7 Neighboring gene Sharpr-MPRA regulatory region 4081 Neighboring gene uncharacterized LOC105376020 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:33404334-33404891 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33407721-33408222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33408223-33408722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33414572-33415103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33415104-33415634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33435285-33435786 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:33438678-33438916 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:33442744-33443943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19834 Neighboring gene Sharpr-MPRA regulatory region 5008 Neighboring gene aquaporin 3 (Gill blood group) Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:33458152-33459351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28297 Neighboring gene uncharacterized LOC107987061 Neighboring gene microRNA 6851 Neighboring gene SUGT1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Nucleolar protein 6 promotes cell proliferation and acts as a potential novel prognostic marker for hepatocellular carcinoma. Meng L, et al. Chin Med J (Engl), 2021 Sep 21. PMID 34561331, Free PMC Article
    2. NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating TWIST1 expression. Liang J, et al. Epigenomics, 2021 Oct. PMID 34607487
    3. Isolation and characterization of a new nucleolar protein, Nrap, that is conserved from yeast to humans. Utama B, et al. Genes Cells, 2002 Feb. PMID 11895476
    4. RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis. Farooq M, et al. Nat Commun, 2020 Nov 16. PMID 33199730, Free PMC Article
    5. Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition. Matafora V, et al. Mol Cell Proteomics, 2009 Oct. PMID 19596686, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating TWIST1 expression.
      Title: NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating TWIST1 expression.
    2. Nucleolar protein 6 promotes cell proliferation and acts as a potential novel prognostic marker for hepatocellular carcinoma.
      Title: Nucleolar protein 6 promotes cell proliferation and acts as a potential novel prognostic marker for hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21959, MGC14896, MGC14921, MGC20838

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CURI complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of UTP-C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in condensed nuclear chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleolar protein 6
    Names
    nucleolar RNA-associated protein
    nucleolar protein 6 (RNA-associated)
    nucleolar protein family 6 (RNA-associated)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022917.5 → NP_075068.2  nucleolar protein 6 isoform alpha

      See identical proteins and their annotated locations for NP_075068.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) encodes the longest isoform (alpha), also known as the long isoform.
      Source sequence(s)
      AF361079, BC008852, CB267269
      Consensus CDS
      CCDS6543.1
      UniProtKB/Swiss-Prot
      Q5T5M3, Q5T5M4, Q7L4G6, Q8N6I0, Q8TEY9, Q8TEZ0, Q8TEZ1, Q9H675, Q9H6R4
      UniProtKB/TrEMBL
      B4DF80
      Related
      ENSP00000297990.4, ENST00000297990.9
      Conserved Domains (6) summary
      pfam03813
      Location:178 → 320
      Nrap; Nrap protein domain 1
      pfam17403
      Location:323 → 463
      Nrap_D2; Nrap protein PAP/OAS-like domain
      pfam17404
      Location:466 → 629
      Nrap_D3; Nrap protein domain 3
      pfam17405
      Location:641 → 846
      Nrap_D4; Nrap protein nucleotidyltransferase domain 4
      pfam17406
      Location:848 → 1003
      Nrap_D5; Nrap protein PAP/OAS1-like domain 5
      pfam17407
      Location:1005 → 1137
      Nrap_D6; Nrap protein domain 6

    2. NM_139235.4 → NP_631981.2  nucleolar protein 6 isoform gamma

      See identical proteins and their annotated locations for NP_631981.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (gamma) lacks nine exons in the 3' region compared to variant alpha. The encoded isoform (gamma), also known as the short isoform, has a unique C-terminus compared to the alpha isoform.
      Source sequence(s)
      AF361081, BC008852, CB267269
      Consensus CDS
      CCDS6544.1
      UniProtKB/Swiss-Prot
      Q9H6R4
      Related
      ENSP00000313978.4, ENST00000353159.6
      Conserved Domains (1) summary
      pfam03813
      Location:165 → 654
      Nrap; Nrap protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      33461353..33473924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423740.1 → XP_047279696.1  nucleolar protein 6 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      33479851..33492421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363572.1 → XP_054219547.1  nucleolar protein 6 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_130793.3: Suppressed sequence

      Description
      NM_130793.3: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H6R4.2 GenPept UniProtKB/Swiss-Prot:Q9H6R4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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