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GTR Home > Conditions/Phenotypes > Amyotrophic lateral sclerosis-parkinsonism-dementia complex

Amyotrophic lateral sclerosis-parkinsonism-dementia complex

Synonyms
Amyotrophic lateral sclerosis, Parkinsonism/Dementia complex of Guam; Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1; Guam disease

Summary

Amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam is a neurodegenerative disorder with unusually high incidence among the Chamorro people of Guam. Both ALS and parkinsonism-dementia are chronic, progressive, and uniformly fatal disorders in this population. Both diseases are known to occur in the same kindred, the same sibship, and even the same individual. See PARK7 (606324) for discussion of a similar phenotype caused by mutation in the DJ1 gene (602533). [from OMIM]

Available tests

8 tests are in the database for this condition.

Check Related conditions for additional relevant tests.

Clinical tests (8 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

  • Also known as: ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK, TRPM7
    Summary: transient receptor potential cation channel subfamily M member 7

Clinical features

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Imported from Human Phenotype Ontology (HPO)

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