MORC2 MORC family CW-type zinc finger 2

Gene ID: 22880, updated on 2-Nov-2024
Gene type: protein coding
Also known as: ZCW3; CMT2Z; DIGFAN; ZCWCC1

Summary

This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

Associated conditions

See all available tests in GTR for this gene

Description	Tests
Charcot-Marie-Tooth disease MedGen: C0007959GeneReviews: Charcot-Marie-Tooth Hereditary Neuropathy Overview	See labs
Charcot-Marie-Tooth disease axonal type 2Z MedGen: C5569025OMIM: 616688GeneReviews: Not available	See labs
Developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy MedGen: C5436781OMIM: 619090GeneReviews: Not available	See labs

Genomic context

Location:: 22q12.2

Sequence:: Chromosome: 22; NC_000022.11 (30925130..30968774, complement)

Total number of exons:: 27

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Variation

Resource	Links for this gene
ClinVar	Variants reported to ClinVar
dbVar	Studies and variants
SNP	Variation Viewer for MORC2 variants
Genome viewer	Explore NCBI-annotated and select non-NCBI annotated genome assemblies

Links

ClinVar
Related medical variations
dbVar
Link from Gene to dbVar
MedGen
Related information in MedGen
OMIM
Link to related OMIM entry
PubMed (OMIM)
Gene links to PubMed derived from omim_pubmed_cited links
RefSeq RNAs
Link to Nucleotide RefSeq RNAs
RefSeqGene
Link to Nucleotide RefSeqGenes
Variation Viewer
Related Variants

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