Panorama Non-invasive Prenatal Test
Clinical Genetic Test
offered by
GTR Test Accession: Help GTR000503131.10
Last updated in GTR: 2020-07-21
Last annual review date for the lab: 2024-01-25 LinkOut
At a Glance
Complete trisomy 21 syndrome; 22q partial monosomy; 5p partial monosomy syndrome more...
15q11-q13; 1p36; 5p; Chromosome 13; Chromosome 18 more...
Molecular Genetics - Targeted variant analysis: SNP Detection
Pregnant women
Panorama® is a screening test for common aneuploidies (trisomy 13, …
Not provided
Ordering Information
Offered by: Help
Specimen Source: Help
Who can order: Help
  • Genetic Counselor
  • Health Care Provider
  • Licensed Dentist
  • Licensed Physician
  • Nurse Practitioner
  • Physician Assistant
  • Registered Nurse
CPT codes: Help
**AMA CPT codes notice
Contact Policy: Help
Post-test email/phone consultation regarding genetic test results and interpretation is provided to patients/families.
Pre-test email/phone consultation regarding genetic test results and interpretation is provided to patients/families.
How to Order: Help
Contact Natera, Inc at 650-249-9090 for kit. Alternatively, 2 x 10cc Streck tubes at room temperature.
Order URL
Test service: Help
Genetic counseling
    Comment: pre and post test consults available
Test development: Help
Test developed by laboratory (no manufacturer test name)
Informed consent required: Help
Pre-test genetic counseling required: Help
Post-test genetic counseling required: Help
Recommended fields not provided:
Conditions Help
Total conditions: 12
Condition/Phenotype Identifier
Test Targets
Chromosomal regions/Mitochondria Help
Total chromosomal regions/mitochondria: 10
Chromosomal region/Mitochondrion Associated condition
Total methods: 1
Method Category Help
Test method Help
Instrument *
Targeted variant analysis
SNP Detection
* Instrument: Not provided
Clinical Information
Test purpose: Help
Clinical validity: Help
Panorama® is a screening test for common aneuploidies (trisomy 13, trisomy 18, trisomy 21, sex chromosome aneuploidy, and triploidy). Panorama’s Extended panel also includes screening for these microdeletion syndromes: 22q11.2 deletion syndrome, Prader Willi syndrome, Angelman syndrome, Cri du Chat syndrome, and 1p36 deletion syndrome. By utilizing SNPs and unique … View more
View citations (2)
  • Dar P, Curnow KJ, Gross SJ, Hall MP, Stosic M, Demko Z, Zimmermann B, Hill M, Sigurjonsson S, Ryan A, Banjevic M, Kolacki PL, Koch SW, Strom CM, Rabinowitz M, Benn P. Clinical experience and follow-up with large scale single-nucleotide polymorphism-based noninvasive prenatal aneuploidy testing. Am J Obstet Gynecol. 2014;211(5):527.e1-527.e17. doi:10.1016/j.ajog.2014.08.006. Epub 2014 Aug 08. PMID: 25111587.
  • Wapner RJ, Babiarz JE, Levy B, Stosic M, Zimmermann B, Sigurjonsson S, Wayham N, Ryan A, Banjevic M, Lacroute P, Hu J, Hall MP, Demko Z, Siddiqui A, Rabinowitz M, Gross SJ, Hill M, Benn P. Expanding the scope of noninvasive prenatal testing: detection of fetal microdeletion syndromes. Am J Obstet Gynecol. 2015;212(3):332.e1-9. doi:10.1016/j.ajog.2014.11.041. Epub 2014 Dec 02. PMID: 25479548.
Target population: Help
Pregnant women
View citations (2)
  • Committee Opinion No. 640: Cell-Free DNA Screening For Fetal Aneuploidy. Obstet Gynecol. 2015;126(3):e31-e37. doi:10.1097/AOG.0000000000001051. PMID: 26287791.
  • Gregg AR, Skotko BG, Benkendorf JL, Monaghan KG, Bajaj K, Best RG, Klugman S, Watson MS. Noninvasive prenatal screening for fetal aneuploidy, 2016 update: a position statement of the American College of Medical Genetics and Genomics. Genet Med. 2016;18(10):1056-65. doi:10.1038/gim.2016.97. Epub 2016 Jul 28. PMID: 27467454.
Recommended fields not provided:
Technical Information
Test Comments: Help
For singleton pregnancies: Panorama® is a screening test for common aneuploidies (trisomy 13, trisomy 18, trisomy 21, sex chromosome aneuploidy, triploidy and 22q11.2). By utilizing SNPs and unique bioinformatics to differentiate between the maternal and fetal genotype, Panorama has high sensitivity and specificity in the NIPT industry for these conditions. … View more
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
Using the Next-generation Aneuploidy Test Using SNPs (NATUS) algorithm, the PanoramaTM prenatal screening test is >99% sensitive and >99% specific for Trisomy 21 (Down Syndrome), Trisomy 13 (Patau Syndrome), triploidy, and fetal sex. Sensitivity for Trisomy 18 (Edwards Syndrome) is 96.4% and for Monosomy X is 92.9% with specificity for … View more
View citations (2)
  • Faas BH, Odibo AO, Cirigliano V, Schielen P, Pergament D, Devers P, Oepkes D, Benn P. Summary of the ISPD Preconference Day, June 3, 2012, Miami Beach. Prenat Diagn. 2013;33(1):1-5. doi:10.1002/pd.4007. Epub 2012 Nov 07. PMID: 23132177.
  • Single-nucleotide polymorphism-based noninvasive prenatal screening in a high-risk and low-risk cohort. Pergament E, et al. Obstet Gynecol. 2014;124(2 Pt 1):210-218. doi:10.1097/AOG.0000000000000363. PMID: 25004354.
Assay limitations: Help
Samples not accepted for multiple gestation when an egg donor and/or a surrogate is used. Samples are also not accepted for patients who have had bone marrow transplant.
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Recommended fields not provided:
Regulatory Approval
FDA Review: Help
Category: FDA exercises enforcement discretion
NYS CLEP Approval: Help
Number: 8417
Status: Approved
Additional Information

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.