Cardiac Arrhythmia Exome Panel
GTR Test Accession: Help GTR000551465.2
Last updated in GTR: 2021-03-10
Last annual review date for the lab: 2024-03-28 LinkOut
At a Glance
Familial atrial fibrillation; Arrhythmogenic right ventricular cardiomyopathy; Arrhythmogenic right ventricular dysplasia 2 more...
ABCC9 (12p12.1); ANK2 (4q25-26); CACNA1C (12p13.33); CACNA1D (3p21.1); CACNB2 (10p12.33-12.31) more...
Molecular Genetics - Sequence analysis of the entire coding region: Next-Generation (NGS)/Massively parallel sequencing (MPS)
Cardiac Arrhythmia
Not provided
Not provided
Ordering Information
Offered by: Help
Northwest Clinical Genomics Laboratory
View lab's website
View lab's test page
Test short name: Help
Specimen Source: Help
Who can order: Help
  • Genetic Counselor
  • Health Care Provider
  • Licensed Physician
Test Order Code: Help
Contact Policy: Help
Pre-test email/phone consultation regarding genetic test results and interpretation is provided to patients/families.
How to Order: Help
Blood and tissue specimens accepted Monday through Friday, 9am - 4pm
Order URL
Test service: Help
Clinical Testing/Confirmation of Mutations Identified Previously
    Comment: Clinical Exome Sequencing
Custom Sequence Analysis
Result interpretation
Test development: Help
Test developed by laboratory (no manufacturer test name)
Informed consent required: Help
Based on applicable state law
Pre-test genetic counseling required: Help
Decline to answer
Post-test genetic counseling required: Help
Decline to answer
Recommended fields not provided:
Conditions Help
Total conditions: 39
Condition/Phenotype Identifier
Test Targets
Genes Help
Total genes: 51
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Total methods: 1
Method Category Help
Test method Help
Instrument *
Sequence analysis of the entire coding region
Next-Generation (NGS)/Massively parallel sequencing (MPS)
* Instrument: Not provided
Clinical Information
Test purpose: Help
Target population: Help
Cardiac Arrhythmia
Variant Interpretation:
What is the protocol for interpreting a variation as a VUS? Help
Each variant is interpreted on an individual basis using techniques such as review of internal and public databases, prior reports in medical literature, sequence conservation, and predicted functional significance. Familial segregation testing to help interpret variants is offered on a case-by-case basis. Variants were assessed for pathogenicity using available information … View more

Are family members with defined clinical status recruited to assess significance of VUS without charge? Help

Will the lab re-contact the ordering physician if variant interpretation changes? Help
Not provided.
Recommended fields not provided:
Technical Information
Test Procedure: Help
Positive results confirmed by Sanger Sequencing
Test Confirmation: Help
Positive results confirmed by Sanger Sequencing
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
Sensitivity of exome panel testing is 98%
Proficiency testing (PT):
Is proficiency testing performed for this test? Help

Method used for proficiency testing: Help

PT Provider: Help
American College of Medical Genetics / College of American Pathologists, ACMG/CAP
Software used to interpret novel variations Help
AlignGVGD, PolyPhen-2, SIFT and CADD

Laboratory's policy on reporting novel variations Help
Lab policy on reporting novel variations The lab follows guidelines published as ACMG recommendations of standards for interpretation and reporting of sequence variants. (Richards S et al Genet Med 2015)
Recommended fields not provided:
Regulatory Approval
FDA Review: Help
Category: FDA exercises enforcement discretion
Additional Information

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.