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GTR Home > Tests > Maturity-onset Diabetes of the Young Panel

Overview

Test name

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Maturity-onset Diabetes of the Young Panel (MODY panel)

Purpose of the test

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This is a clinical test intended for Help: Diagnosis, Monitoring, Mutation Confirmation, Pre-symptomatic, Predictive, Recurrence, Therapeutic management

Condition

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Click Indication tab for more information.

How to order

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Submit test-specific paperwork with sample of blood or saliva
Order URL Help: http://www.med.upenn.edu/genetics/gdl

Specimen source

Amniocytes
Amniotic fluid
Cell culture
Chorionic villi
Cord blood
Fetal blood
Isolated DNA
Peripheral (whole) blood
Product of conception (POC)
Saliva
Skin

Methodology

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Molecular Genetics
DDeletion/duplication analysis
Microarray
  • Agilent SureSelect
CSequence analysis of the entire coding region
Next-Generation (NGS)/Massively parallel sequencing (MPS)
  • Ion Torrent

Summary of what is tested

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Clinical utility

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Guidance for selecting a drug therapy and/or dose

Citations
  • Maturity onset diabetes of the young: clinical characteristics, diagnosis and management. - PubMed ID: 23539835

Clinical validity

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The most common molecular defects associated with MODY are in the GCK, HNF1A, HNF4A and HNF1B genes. About 80% of individuals with MODY will have a mutation in one of the 4 genes listed above. See table on page 2 for summary frequency of genes related to MODY along with the clinical characteristics.

Citations

Test services

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  • Clinical Testing/Confirmation of Mutations Identified Previously

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.