ALK ROS1 Fusion Test
Clinical Genetic Test
offered by
GTR Test Accession: Help GTR000566698.1
Last updated in GTR: 2019-04-04
Last annual review date for the lab: 2022-04-08 Past due LinkOut
At a Glance
Diagnosis; Drug Response; Monitoring; ...
Lung carcinoma; EGFR-related lung cancer; GSTM1-related lung cancer; ...
Genes (2): Help
ALK (2p23.2-23.1), ROS1 (6q22.1)
Molecular Genetics - RNA analysis: RT-qPCR
Lung cancer patients
Not provided
Not provided
Ordering Information
Offered by: Help
Circulogene Theranostics
View lab's website
Test short name: Help
ALK ROS1 Fusion
Specimen Source: Help
Who can order: Help
  • Health Care Provider
  • Licensed Physician
Contact Policy: Help
Post-test email/phone consultation regarding genetic test results and interpretation is provided to patients/families.
How to Order: Help
Please call 205-278-1601/855-614-7083 or email for ordering details.
Order URL
Test service: Help
Clinical Testing/Confirmation of Mutations Identified Previously
Liquid Biopsy NGS Testing
Test additional service: Help
Custom mutation-specific/Carrier testing
Test development: Help
Test developed by laboratory (no manufacturer test name)
Informed consent required: Help
Decline to answer
Pre-test genetic counseling required: Help
Decline to answer
Post-test genetic counseling required: Help
Decline to answer
Recommended fields not provided:
Conditions Help
Total conditions: 5
Condition/Phenotype Identifier
Test Targets
Genes Help
Total genes: 2
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Total methods: 1
Method Category Help
Test method Help
RNA analysis
Applied Biosystems 7900HT Sequence Detection System
Clinical Information
Test purpose: Help
Diagnosis; Drug Response; Monitoring; Therapeutic management
Target population: Help
Lung cancer patients
View citations (1)
  • ALK and ROS1 as a joint target for the treatment of lung cancer: a review. Puig de la Bellacasa R, et al. Transl Lung Cancer Res. 2013;2(2):72-86. doi:10.3978/j.issn.2218-6751.2013.03.1. PMID: 25806218.
Recommended fields not provided:
Technical Information
Test Platform:
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
In a test accuracy study, a total of 29 samples from lung cancer patients that had been analyzed using either FISH (Fluorescence in situ hybridization), digital droplet PCR or real-time PCR at other reference laboratories were re-tested using Circulogene ALK/ROS1 Gene Fusion assay. All samples gave 100% agreement.
Proficiency testing (PT):
Is proficiency testing performed for this test? Help

Method used for proficiency testing: Help
Recommended fields not provided:
Regulatory Approval
FDA Review: Help
Category: Not Applicable
Additional Information

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.