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NGS HLA-A,B,C,DR,DQ,DP,DRB34
Clinical Genetic Test
Help
offered by
Allogen Laboratories-Cleveland Clinic
GTR Test Accession: Help GTR000569607.2
INHERITED DISEASE
Last updated in GTR: 2019-12-05
View version history
Last annual review date for the lab: 2023-09-20 LinkOut
At a Glance
Test purpose: Help
Screening
Conditions (1): Help
Hla modifier
Genes (11): Help
HLA-A (6p22.1); HLA-B (6p21.33); HLA-C (6p21.33); HLA-DPA1 (6p21.32); HLA-DPB1 (6p21.32) more...
Methods (1): Help
Molecular Genetics - Sequence analysis of select exons: Next-Generation (NGS)/Massively parallel sequencing (MPS)
Target population: Help
11 Locus typing of Human Leukocyte Antigens(HLA) Used for Solid …
Clinical validity: Help
Not provided
Clinical utility: Help
Not provided
Ordering Information
Offered by: Help
Allogen Laboratories-Cleveland Clinic
Test short name: Help
NGSHLA
Specimen Source: Help
  • Peripheral (whole) blood
Who can order: Help
  • Health Care Provider
Test Order Code: Help
NGSHLA
CPT codes: Help
**AMA CPT codes notice

Copyright: 2023 American Medical Association. All rights reserved.

Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
This test can be ordered through Cleveland Clinic Electronic Medical Record-EPIC.
Test service: Help
Histocompatibility
Informed consent required: Help
Decline to answer
Pre-test genetic counseling required: Help
Decline to answer
Post-test genetic counseling required: Help
Decline to answer
Recommended fields not provided:
Lab contact for this test, Test strategy, Test development
Conditions Help
Total conditions: 1
Condition/Phenotype Identifier
Test Targets
Genes Help
Total genes: 11
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Methodology
Total methods: 1
Method Category Help
Test method Help
Instrument *
Sequence analysis of select exons
Next-Generation (NGS)/Massively parallel sequencing (MPS)
* Instrument: Not provided
Clinical Information
Test purpose: Help
Screening
Target population: Help
11 Locus typing of Human Leukocyte Antigens(HLA) Used for Solid Organ and Peripheral Blood Stem Cell transplantation
Recommended fields not provided:
Clinical validity, Clinical utility, What is the protocol for interpreting a variation as a VUS?, Are family members with defined clinical status recruited to assess significance of VUS without charge?, Will the lab re-contact the ordering physician if variant interpretation changes?, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report
Technical Information
Availability: Help
Tests performed
Interpretation performed in-house
Report generated in-house
Specimen preparation performed in-house
Wet lab work performed in-house
Analytical Validity: Help
Test was developed and validated using ASHI approved validation guidelines for HLA NGS based typing and compared at least (20) samples to historic samples tested by SBT Sequenced Based typing.
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Yes

Method used for proficiency testing: Help
Formal PT program

PT Provider: Help
American Society for Histocompatibility and Immunogenetics
Recommended fields not provided:
Test Confirmation, Assay limitations, Description of internal test validation method, Citations for Analytical validity, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Not provided
Additional Information
Consumer resources:

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.