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HemeComplete NextGen Sequencing Assay with Calreticulin Exon 9 Mutation, FLT3 … see more HemeComplete NextGen Sequencing Assay with Calreticulin Exon 9 Mutation, FLT3 ITD and TKD Analysis and T-Cell Clonality Analysis  see less
Clinical Genetic Test
Help
offered by
PathGroup
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LinkOut
GTR Test Accession: Help GTR000575342.2
CAP
CANCERHEMATOLOGYIMMUNOLOGY ... View more
Last updated in GTR: 2022-12-21
View version history
Last annual review date for the lab: 2022-12-28 Past due LinkOut
At a Glance
Test purpose: Help
Diagnosis; Drug Response; Monitoring; ...
Conditions (23): Help
Thrombocythemia 1; Acquired polycythemia vera; Acute lymphoid leukemia; ...
Genes (160): Help
ABL1 (9q34.12), AKT1 (14q32.33), AKT2 (19q13.2), AKT3 (1q43-44), ALK (2p23.2-23.1), ...
Methods (2): Help
Molecular Genetics - Targeted variant analysis: Next-Generation (NGS)/Massively parallel sequencing (MPS); PCR
Target population: Help
Hematological neoplasms and associated syndromes, myeloproliferative neoplasms, acute myeloid leukemia, …
Clinical validity: Help
Not provided
Clinical utility: Help
Not provided
Ordering Information
Offered by: Help
PathGroup
View lab's website
View lab's test page
Test short name: Help
NGSHM03_CALR_FLT3ITD_TKD_Tcell_clonality
Specimen Source: Help
Who can order: Help
  • Health Care Provider
Test Order Code: Help
NGSHEME_CALR_FLT3ITD_TKD_Tcell_clonality
View other test codes
CPT codes: Help
**AMA CPT codes notice

Copyright: 2023 American Medical Association. All rights reserved.

Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
NGSHEME_CALR_FLT3ITD_TKD_Tcell_clonality
Test development: Help
Test developed by laboratory (no manufacturer test name)
Informed consent required: Help
No
Pre-test genetic counseling required: Help
No
Post-test genetic counseling required: Help
No
Recommended fields not provided:
Lab contact for this test, Test strategy
Conditions Help
Total conditions: 23
Condition/Phenotype Identifier
Test Targets
Genes Help
Total genes: 160
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Methodology
Total methods: 2
Method Category Help
Test method Help
Instrument *
Targeted variant analysis
Next-Generation (NGS)/Massively parallel sequencing (MPS)
Targeted variant analysis
PCR
* Instrument: Not provided
Clinical Information
Test purpose: Help
Diagnosis; Drug Response; Monitoring; Predictive; Prognostic
Target population: Help
Hematological neoplasms and associated syndromes, myeloproliferative neoplasms, acute myeloid leukemia, Polycythemia vera, essential thrombocythemia, myelofibrosis
Recommended fields not provided:
Clinical validity, Clinical utility, What is the protocol for interpreting a variation as a VUS?, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report
Technical Information
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
SmartGenomics Heme: Analytic sensitivity >99% when variant is present at >5% VAF with minimum of 20% tumor cells. Analytic specificity of >99%. Precision and reproducibility of >98%. CALR, FLT3: Analytic sensitivity of 1%. Analytic specificity of >99%. T-cell Clonality: Analytic sensitivity >90% when clonality is present in more than >5% … View more
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Yes

Method used for proficiency testing: Help
Formal PT program

PT Provider: Help
American College of Medical Genetics / College of American Pathologists, ACMG/CAP
Recommended fields not provided:
Test Confirmation, Assay limitations, Description of internal test validation method, Citations for Analytical validity, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Category: FDA exercises enforcement discretion
Additional Information

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.