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Mismatch Repair by Immunohistochemistry with Reflex to BRAF Codon 600 … see more Mismatch Repair by Immunohistochemistry with Reflex to BRAF Codon 600 Mutation and MLH1 Promoter Methylation  see less
Clinical Genetic Test
Help
offered by
ARUP Laboratories, Molecular Oncology
View lab's test page
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GTR Test Accession: Help GTR000575553.2
NYS CLEP
INHERITED DISEASEINHERITED DISEASE SUSCEPTIBILITYCANCER ... View more
Last updated in GTR: 2020-04-01
View version history
Last annual review date for the lab: 2023-11-27 LinkOut
At a Glance
Test purpose: Help
Screening; Diagnosis
Conditions (1): Help
Lynch syndrome
Enzymes (1): Help
Mismatch repair endonuclease PMS2
Genes (2): Help
BRAF (7q34), MLH1 (3p22.2)
Proteins (3): Help
DNA mismatch repair protein Mlh1; DNA mismatch repair protein Msh2; DNA mismatch repair protein Msh6
Methods (3): Help
Biochemical Genetics - Immunohistochemistry: Immunohistochemistry; ...
Target population: Help
Not provided
Clinical validity: Help
Not provided
Clinical utility: Help
Not provided
Ordering Information
Offered by: Help
ARUP Laboratories, Molecular Oncology
View lab's website
View lab's test page
Who can order: Help
  • Health Care Provider
Test Order Code: Help
2002327
Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
Informed consent required: Help
Decline to answer
Pre-test genetic counseling required: Help
Decline to answer
Post-test genetic counseling required: Help
Decline to answer
Recommended fields not provided:
How to Order, Specimen source, Lab contact for this test, Test strategy, Test development
Conditions Help
Total conditions: 1
Condition/Phenotype Identifier
Test Targets
Enzymes Help
Total enzymes: 1
Enzyme Associated Condition
Genes Help
Total genes: 2
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Proteins Help
Total proteins: 3
Protein Associated Condition
Methodology
Total methods: 3
Method Category Help
Test method Help
Instrument *
Immunohistochemistry
Immunohistochemistry
Methylation analysis
Methylation-specific PCR
Targeted variant analysis
RT-PCR
* Instrument: Not provided
Clinical Information
Test purpose: Help
Screening; Diagnosis
Recommended fields not provided:
Clinical validity, Clinical utility, Target population, What is the protocol for interpreting a variation as a VUS?, Are family members with defined clinical status recruited to assess significance of VUS without charge?, Will the lab re-contact the ordering physician if variant interpretation changes?, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report
Technical Information
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
BRAF Limit of detection: 10 percent mutant alleles. MLH1 promoter hypermethylation Analytical Sensitivity: Methlations levels below 10 percent are reported as negative.
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Yes

Method used for proficiency testing: Help
Intra-Laboratory
Recommended fields not provided:
Test Confirmation, Assay limitations, Description of internal test validation method, Citations for Analytical validity, PT Provider, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Not provided
NYS CLEP Approval: Help
Number: 11834
Status: Approved
Additional Information

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