Classic view of this page
Lung Cancer Driver Profile
Clinical Genetic Test
Help
offered by
GoPath Diagnostics
View lab's test page
LinkOut
GTR Test Accession: Help GTR000591172.1
CAP
CANCERRESPIRATORY DISEASE
Registered in GTR: 2020-07-01
View version history
Last annual review date for the lab: 2023-06-14 Past due LinkOut
At a Glance
Test purpose: Help
Therapeutic management
Conditions (1): Help
Lung carcinoma
Chromosomal regions/ Mitochondria (1): Help
6q22
Genes (1): Help
EGFR (7p11.2)
Proteins (1): Help
PDL1
Methods (3): Help
Biochemical Genetics - Immunohistochemistry: mismatch repair proteins for MLH1, MSH2, MSH6, PMS2; ...
Target population: Help
patients with lung cancer diagnosis determining which treatment drug to …
Clinical validity: Help
10% of patients with NSCLC have a mutation in EGFR
Clinical utility: Help
Not provided
Ordering Information
Offered by: Help
GoPath Diagnostics
View lab's website
View lab's test page
Test short name: Help
LUNGC22
Specimen Source: Help
  • Fresh tissue
  • Frozen tissue
  • Paraffin block
Who can order: Help
  • Health Care Provider
  • Licensed Physician
  • Physician Assistant
Test Order Code: Help
Lung Cancer Driver Profile
CPT codes: Help
**AMA CPT codes notice

Copyright: 2023 American Medical Association. All rights reserved.

Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
Please include all these CPT codes for this panel:
81210x1, 81235 x1, 88381x1, G0452x1, 88377 x2, 88360 x1


contact us:
Toll Free: 855-GOPATH9
Fax: 224-588-9941
Links
www.gopathgenetics.com
we will sent up account for you to receive testing kits and requisitions.
Order URL
Test service: Help
molecular genomic testing
Test development: Help
Manufactured (research use only; not FDA-reviewed)
Informed consent required: Help
Based on applicable state law
Pre-test genetic counseling required: Help
No
Post-test genetic counseling required: Help
No
Recommended fields not provided:
Lab contact for this test, Test strategy
Conditions Help
Total conditions: 1
Condition/Phenotype Identifier
Test Targets
Chromosomal regions/Mitochondria Help
Total chromosomal regions/mitochondria: 1
Chromosomal region/Mitochondrion Associated condition
Genes Help
Total genes: 1
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Proteins Help
Total proteins: 1
Protein Associated Condition
Methodology
Total methods: 3
Method Category Help
Test method Help
Instrument
Immunohistochemistry
mismatch repair proteins for MLH1, MSH2, MSH6, PMS2
Fluorescence in situ hybridization (FISH)
Fluorescence in situ hybridization (FISH)
ABBOTT VP 2000 PROCESSOR
Deletion/duplication analysis
PCR
ABI 3130XL Genetic Analyzer
Clinical Information
Test purpose: Help
Therapeutic management
Clinical validity: Help
10% of patients with NSCLC have a mutation in EGFR
Target population: Help
patients with lung cancer diagnosis determining which treatment drug to use. Suggested therapy: erlotinib, afatinib, gefitinib.
Variant Interpretation:
What is the protocol for interpreting a variation as a VUS? Help
Interpretation and classification of clinical significance of the detected variant are based on catalogued information from the NCBI ClinVar database (http://www.ncbi.nlm.nih.gov/clinvar/variation/), LOVD database (http://databases.lovd.nl/ shared/genes/) and other locus specific databases as well as information from published literatures

Are family members with defined clinical status recruited to assess significance of VUS without charge? Help
No.

Will the lab re-contact the ordering physician if variant interpretation changes? Help
Yes. our GeneticsNow service covers it all - please use our website www.gopathlabs.com
Recommended fields not provided:
Clinical utility, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report
Technical Information
Test Platform:
NextGENe for CNV analysis
Test Confirmation: Help
rerun sequencing/CNV analysis on same sample if sufficient otherwise a new sample is requested
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
test predicts 100% of prognosis and therapeutic methods
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Yes

Method used for proficiency testing: Help
Formal PT program

PT Provider: Help
American College of Medical Genetics / College of American Pathologists, ACMG/CAP
VUS:
Software used to interpret novel variations Help
NextGENe

Laboratory's policy on reporting novel variations Help
formal reports
Recommended fields not provided:
Assay limitations, Description of internal test validation method, Citations for Analytical validity, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Category: Not Applicable
Additional Information

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.