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Quantitative Chimerism
Clinical Genetic Test
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offered by
Molecular Genetics and Cytogenetics, Clinical Laboratory Service
GTR Test Accession: Help GTR000591295.1
CAP
INHERITED DISEASECANCERHEMATOLOGY ... View more
Registered in GTR: 2020-08-10
View version history
Last annual review date for the lab: 2024-07-31 LinkOut
At a Glance
Test purpose: Help
Therapeutic management
Conditions (1): Help
Acute lymphoid leukemia
Chromosomal regions/ Mitochondria (1): Help
Microsatellite
Methods (1): Help
Molecular Genetics - Targeted variant analysis: Multiplex PCR
Target population: Help
Not provided
Clinical validity: Help
The term chimerism refers to the presence of hematopoietic cells …
Clinical utility: Help
Guidance for management
Ordering Information
Offered by: Help
Molecular Genetics and Cytogenetics, Clinical Laboratory Service
View lab's website
Test short name: Help
Chimerism
Specimen Source: Help
  • Bone marrow
  • Buccal swab
  • Cord blood
  • Dried blood spot (DBS) card
  • Isolated DNA
  • Peripheral (whole) blood
  • Saliva
Who can order: Help
  • Licensed Physician
Test Order Code: Help
2121
Lab contact: Help
Marcela Lagos, MD, Lab Director
mlagos@med.puc.cl
+56 223548515
Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
Test service: Help
Identity Testing
Informed consent required: Help
Decline to answer
Pre-test genetic counseling required: Help
Decline to answer
Post-test genetic counseling required: Help
Decline to answer
Recommended fields not provided:
How to Order, Test strategy, Test development
Conditions Help
Total conditions: 1
Condition/Phenotype Identifier
Test Targets
Chromosomal regions/Mitochondria Help
Total chromosomal regions/mitochondria: 1
Chromosomal region/Mitochondrion Associated condition
Methodology
Total methods: 1
Method Category Help
Test method Help
Instrument
Targeted variant analysis
Multiplex PCR
AmpFLSTR™ Identifiler™ Direct PCR Amplification Kit
Clinical Information
Test purpose: Help
Therapeutic management
Clinical validity: Help
The term chimerism refers to the presence of hematopoietic cells derived from another individual (in this case the donor) product of a transplantation into a recipient individual (patient). To differentiate between receiver and donor, the same genetic markers, STR, are used as for identification of individuals in general. The method … View more
View citations (1)
  • Hematopoietic chimerism monitoring based on STRs: quantitative platform performance on sequential samples. Kristt D, et al. J Biomol Tech. 2005;16(4):380-91. PMID: 16522860.
Clinical utility: Help
Guidance for management
View citations (1)
  • Hematopoietic chimerism monitoring based on STRs: quantitative platform performance on sequential samples. Kristt D, et al. J Biomol Tech. 2005;16(4):380-91. PMID: 16522860.

Variant Interpretation:
Are family members with defined clinical status recruited to assess significance of VUS without charge? Help
Decline to answer.

Will the lab re-contact the ordering physician if variant interpretation changes? Help
Decline to answer.
Recommended fields not provided:
Target population, What is the protocol for interpreting a variation as a VUS?, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report
Technical Information
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
AmpF/STR Identifiler kit was used for validation. The number of informative loci was evaluated in 19 patients, of whom 8 received transplantation from an unrelated donor and 11 from cord blood. The detection limit of the technique was established between 5% and 95% of chimerism based on the donor. The … View more
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Yes

Method used for proficiency testing: Help
Formal PT program

PT Provider: Help
American College of Medical Genetics / College of American Pathologists, ACMG/CAP
Recommended fields not provided:
Test Confirmation, Assay limitations, Description of internal test validation method, Citations for Analytical validity, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Not provided
Additional Information

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