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Zygosity Testing (Multiple Births)
Clinical Genetic Test
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offered by
Mayo Clinic Laboratories
View lab's test page
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GTR Test Accession: Help GTR000593181.3
INHERITED DISEASE
Last updated in GTR: 2024-04-11
View version history
Last annual review date for the lab: 2024-05-28 LinkOut
At a Glance
Test purpose: Help
Risk Assessment
Conditions (2): Help
Twinning, monozygotic; Dizygotic twins
Chromosomal regions/ Mitochondria (24): Help
10q26.3; 11p15.5; 12p13.2; 12p13.31; 13q22-31; ...
Methods (1): Help
Molecular Genetics - Linkage analysis: Polymerase Chain Reaction (PCR)/Microsatellite markers
Target population: Help
Determining genetic risk for an individual whose twin or triplet …
Clinical validity: Help
Not provided
Clinical utility: Help
Predictive risk information for patient and/or family members
Ordering Information
Offered by: Help
Mayo Clinic Laboratories
View lab's website
View lab's test page
Test short name: Help
MULT
Specimen Source: Help
Who can order: Help
  • Genetic Counselor
  • Health Care Provider
  • Licensed Dentist
  • Licensed Physician
  • Nurse Practitioner
  • Physician Assistant
  • Public Health Mandate
  • Registered Nurse
Lab contact: Help
Huong Cabral, MS, Certified Genetic counselor, CGC, Genetic Counselor
GCMolgen@mayo.edu
1-800-533-1710
Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
https://www.mayocliniclabs.com/test-catalog/Specimen/35577
Order URL
Test development: Help
Test developed by laboratory (no manufacturer test name)
Informed consent required: Help
Based on applicable state law
Pre-test genetic counseling required: Help
Decline to answer
Post-test genetic counseling required: Help
Decline to answer
Recommended fields not provided:
Test strategy
Conditions Help
Total conditions: 2
Condition/Phenotype Identifier
Test Targets
Chromosomal regions/Mitochondria Help
Total chromosomal regions/mitochondria: 24
Chromosomal region/Mitochondrion Associated condition
Methodology
Total methods: 1
Method Category Help
Test method Help
Instrument *
Linkage analysis
Polymerase Chain Reaction (PCR)/Microsatellite markers
* Instrument: Not provided
Clinical Information
Test purpose: Help
Risk Assessment
Clinical utility: Help
Predictive risk information for patient and/or family members
View citations (1)

Target population: Help
Determining genetic risk for an individual whose twin or triplet is affected with a genetic disorder for which a specific genetic test is not available (or such testing is uninformative); Assessment of risks prenatally when one fetus of multiples is known to be affected by a specific disorder; Organ or … View more
View citations (3)
  • Routine applications of DNA fingerprinting with the oligonucleotide probe (CAC)5/(GTG)5. Neitzel H, et al. Clin Genet. 1991;39(2):97-103. doi:10.1111/j.1399-0004.1991.tb02994.x. PMID: 1849805.
  • Prenatal diagnosis of twin zygosity by DNA 'fingerprint' analysis. Appelman Z, et al. Prenat Diagn. 1994;14(4):307-9. doi:10.1002/pd.1970140412. PMID: 8066042.
  • Allen RW, Polesky HF. Parentage and Relationship Testing. In: Molecular Pathology in Clinical Practice. 2nd edition. Edited by DGB Leonard. Springer International Publishing; 2016:811-21
Variant Interpretation:
Are family members with defined clinical status recruited to assess significance of VUS without charge? Help
Decline to answer. Contact lab for details

Will the lab re-contact the ordering physician if variant interpretation changes? Help
No.
Research:
Is research allowed on the sample after clinical testing is complete? Help
Research testing is only performed under IRB approved protocol with an opt-out policy in place.
Recommended fields not provided:
Clinical validity, What is the protocol for interpreting a variation as a VUS?, Sample negative report, Sample positive report
Technical Information
Test Procedure: Help
PCR-based assays that recognize highly variable regions of human DNA are used to provide a genotype for multiples and their parents. The number of markers (microsatellites) used is determined on a case-by-case basis to ensure >99.9% predictive value. Calculation of zygosity probability is made using Bayesian analysis. (Unpublished Mayo method)
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
Analytical sensitivity, specificity, and accuracy are ≥ 99%.
Assay limitations: Help
Test results should be interpreted in the context of clinical findings, family history, and other laboratory data. Errors in our interpretation of results may occur if information given is inaccurate or incomplete. This test will detect nonpaternity. Chain of custody documentation is not available. This test is not intended for … View more
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Yes

Method used for proficiency testing: Help
Platform PT performed
Recommended fields not provided:
Test Confirmation, Citations to support assay limitations, Description of internal test validation method, Citations for Analytical validity, PT Provider, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Category: FDA exercises enforcement discretion
Additional Information
Consumer resources:

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.