Overview
Precision HealthPGx Panel (25 Genes)
This is a clinical test intended for HelpPurposes or indications for the test. Lab-provided.: Drug Response, Predictive, Risk Assessment, Screening, Therapeutic management
Click Indication tab for more information.
Acceptable specimen sources are blood, extracted DNA (gDNA) and saliva.
Peripheral Whole Blood: 3-5mL in EDTA tube (lavender top). This is our preferred specimen type;
Extracted DNA: 1ug DNA (please indicate sample source on test request form);
Saliva: Use DNA Genotek Oragene DNA (OG-500) kit.
Buccal swab: Collect using Copan hDNAFree FLOQSwabs (Cat# 50E010D01) or IsoHelix RapiDri Buccal swab with self-drying pouch (Cat# RD-01) according to manufacturer’s instructions.
All samples should be shipped Sunday through Thursday (next day delivery only). Contact for availability of alternative shipping schedules and additional shipping requirements. Shipping is acceptable at ambient or refrigerated temperature.
Any blood samples collected and not shipped immediately should be refrigerated and shipped overnight as soon as possible (less than 5-7 days after collection) to ensure specimen stability and quality.
Order URL HelpLink to the laboratory webpage with information about how to order this test. Please note that clicking on this link will open a new tab in your internet browser.: https://www.rprdx.com/testing/how-it-works/
Specimen source
Buccal swab
Isolated DNA
Peripheral (whole) blood
Saliva
- Molecular Genetics
- DDeletion/duplication analysis
- Microarray
- Affymetrix Gene Profiling Array cGMP U133 P2
- TTargeted variant analysis
- Microarray
- Affymetrix GeneTitan® MC
- Affymetrix GeneTitan® MC
- Affymetrix Gene Profiling Array cGMP U133 P2
Guidance for selecting a drug therapy and/or dose
Citations- A clinician-driven automated system for integration of pharmacogenetic interpretations into an electronic medical record. - PubMed ID:
22990750
- Development and use of active clinical decision support for preemptive pharmacogenomics. - PubMed ID:
23978487
Pre-emptive clinical implementation
To determine the diagnostic sensitivity, we utilized the manufacturer’s recommended input concentration and analysis QC thresholds. We demonstrated adherence to our validation threshold (i.e. ≥ 95% sensitivity) in detection of true positive results, with a false negative rate of ≤ 5%.
To determine the diagnostic specificity, we utilized the manufacturer’s recommended input concentration and analysis QC thresholds. The PharmacoScan™ Assay demonstrated ≥ 99% sensitivity in detecting the correct genotypes of each sample tested.
This test ideally is utilized pre-emptively (prior to receiving drug medication) or as a reflex testing when an adverse reaction to a medication has been observed. 000 Acceptable specimen sources are blood, extracted DNA (gDNA) and saliva.
Peripheral Whole Blood: 3-5mL in EDTA tube (lavender top). This is our preferred specimen type;
Extracted DNA: 1ug DNA (please indicate sample source on test request form);
Saliva: Use DNA Genotek Oragene DNA (OG-500) kit.
Buccal swab: Collect using Copan hDNAFree FLOQSwabs (Cat# 50E010D01) or IsoHelix RapiDri Buccal swab with self-drying pouch (Cat# RD-01) according to manufacturer’s instructions.
All samples should be shipped Sunday through Thursday (next day delivery only). Contact for availability of alternative shipping schedules and additional shipping requirements. Shipping is acceptable at ambient or refrigerated temperature.
Any blood samples collected and not shipped immediately should be refrigerated and shipped overnight as soon as possible (less than 5-7 days after collection) to ensure specimen stability and quality.
