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Tempus xR
Clinical Genetic Test
Help
offered by
Tempus Labs, Inc.
View lab's test page
LinkOut
GTR Test Accession: Help GTR000611948.1
CAP
CANCER
Last updated in GTR: 2023-08-25
View version history
Last annual review date for the lab: 2023-09-01 LinkOut
At a Glance
Test purpose: Help
Predictive; Prognostic; Therapeutic management
Conditions (2): Help
Solid tumor; Hematologic neoplasm
Analytes (3): Help
EGFRvIII altered splicing; MET exon 14 altered splicing; fusion detection
Methods (1): Help
Molecular Genetics - RNA analysis: Next-Generation (NGS)/Massively parallel sequencing (MPS)
Target population: Help
Patients with advanced solid and hematologic malignancies, considered for targeted …
Clinical validity: Help
Not provided
Clinical utility: Help
Not provided
Ordering Information
Offered by: Help
Tempus Labs, Inc.
View lab's website
View lab's test page
Test short name: Help
xR
Specimen Source: Help
Who can order: Help
  • Licensed Physician
Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
To order the Tempus xT, xR or xF test:
1. Retrieve a Tempus blood or saliva collection kit. All required forms are contained in the box.
2. Complete the Consent Form with the patient.
3. Complete the Requisition Form. Physician and Patient signatures are both required.
4. Complete the …
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Order URL
Test service: Help
Clinical Testing/Confirmation of Mutations Identified Previously
DNA sequencing
    Comment: Tempus xT: DNA sequencing for 648 genes (Tumor and matched normal)
RNA sequencing
    Comment: Tempus xR: RNA whole transcriptome sequencing
DNA sequencing
    Comment: Tempus xF: ctDNA sequencing for 105 genes
DNA sequencing
    Comment: Tempus nP: DNA sequencing for 13 genes with known roles in pharmacodynamics, pharmacokinetics, and immune responses to certain medications
Test development: Help
Test developed by laboratory (no manufacturer test name)
Informed consent required: Help
Based on applicable state law
Pre-test genetic counseling required: Help
No
Post-test genetic counseling required: Help
No
Recommended fields not provided:
Test Order Code, Lab contact for this test, Test strategy
Conditions Help
Total conditions: 2
Condition/Phenotype Identifier
Test Targets
Analytes Help
Total analytes: 3
Analyte Associated Condition
Methodology
Total methods: 1
Method Category Help
Test method Help
Instrument
RNA analysis
Next-Generation (NGS)/Massively parallel sequencing (MPS)
Novaseq 6000
Clinical Information
Test purpose: Help
Predictive; Prognostic; Therapeutic management
Target population: Help
Patients with advanced solid and hematologic malignancies, considered for targeted therapies, unlikely to respond to conventional chemotherapies, or for whom no conventional therapies exist.
Variant Interpretation:
Are family members with defined clinical status recruited to assess significance of VUS without charge? Help
No.

Will the lab re-contact the ordering physician if variant interpretation changes? Help
No.
Recommended fields not provided:
Clinical validity, Clinical utility, What is the protocol for interpreting a variation as a VUS?, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report
Technical Information
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
In specimens with a tumor content of at least 20%, post macrodissection (if necessary), clinical sequencing is optimized to generate at least 50,000,000 unique reads. At 20% tumor content limit of detection (LOD), positive percentage agreement (PPA) and negative percentage agreement (NPA) for targeted rearrangements/fusions are 100.0% and 99.9%, respectively. … View more
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Yes

Method used for proficiency testing: Help
Formal PT program

PT Provider: Help
College of American Pathologists, CAP

CAP Testing Information Help
Fusion RNA; RNA sequencing; RNA
VUS:
Software used to interpret novel variations Help
N/A
Recommended fields not provided:
Test Confirmation, Assay limitations, Description of internal test validation method, Citations for Analytical validity, Description of PT method
Regulatory Approval
FDA Review: Help
Not provided
Additional Information
Consumer resources:

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.