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Simple febrile seizure

MedGen UID:
101773
Concept ID:
C0149886
Disease or Syndrome
Synonyms: Simple febrile convulsions; Simple febrile seizures
SNOMED CT: Simple febrile seizure (432354000); Simple febrile convulsion (432354000)
 
HPO: HP:0011171

Definition

A short generalized seizure, of a duration of <15 min, not recurring within 24 h, occurring during a febrile episode not caused by an acute disease of the nervous system intracranial infection or severe metabolic disturbance. [from HPO]

Conditions with this feature

Epilepsy, familial focal, with variable foci 4
MedGen UID:
1644614
Concept ID:
C4693694
Disease or Syndrome
SCN3A-related neurodevelopmental disorder (SCN3A-ND) encompasses a spectrum of clinical severity associated with epilepsy and/or brain malformation. Affected individuals may have (a) developmental and epileptic encephalopathy (DEE) (i.e., intractable seizures with developmental delays associated with ongoing epileptiform EEG activity) with or without malformations of cortical development; or (b) malformations of cortical development with or without mild focal epilepsy. Some degree of early childhood developmental delay is seen in all affected individuals; the severity varies widely, ranging from isolated speech delay to severe developmental delay. Infantile hypotonia is common but may be mild or absent in those without DEE. In those with DEE, seizure onset is typically in the first six to 12 months of life. A variety of seizure types have been described. Seizures remain intractable to multiple anti-seizure medications in approximately 50% of individuals with DEE without malformations of cortical development (MCD) and in 90% of individuals with DEE and MCD. Seizures may be absent or infrequent in those without DEE. Brain MRI findings range from normal to showing thinning or hypoplasia of the corpus callosum, to various malformations of cortical development. Autonomic dysregulation, oromotor dysfunction leading to the need for gastrostomy tube placement, progressive microcephaly, hyperkinetic movement disorder, and cortical visual impairment can also be seen in those with DEE.

Professional guidelines

PubMed

Ferretti A, Riva A, Fabrizio A, Bruni O, Capovilla G, Foiadelli T, Orsini A, Raucci U, Romeo A, Striano P, Parisi P
Ital J Pediatr 2024 May 12;50(1):95. doi: 10.1186/s13052-024-01666-1. PMID: 38735928Free PMC Article
Expert Panel on Pediatric Imaging, Trofimova A, Milla SS, Ryan ME, Pruthi S, Blount JP, Desai NK, Glenn OA, Islam MP, Kadom N, Mirsky DM, Myseros JS, Partap S, Radhakrishnan R, Rose E, Soares BP, Trout AT, Udayasankar UK, Whitehead MT, Karmazyn B
J Am Coll Radiol 2021 May;18(5S):S199-S211. doi: 10.1016/j.jacr.2021.02.020. PMID: 33958113
Baumann RJ
Paediatr Drugs 2001;3(8):585-92. doi: 10.2165/00128072-200103080-00003. PMID: 11577923

Recent clinical studies

Etiology

Expert Panel on Pediatric Imaging, Trofimova A, Milla SS, Ryan ME, Pruthi S, Blount JP, Desai NK, Glenn OA, Islam MP, Kadom N, Mirsky DM, Myseros JS, Partap S, Radhakrishnan R, Rose E, Soares BP, Trout AT, Udayasankar UK, Whitehead MT, Karmazyn B
J Am Coll Radiol 2021 May;18(5S):S199-S211. doi: 10.1016/j.jacr.2021.02.020. PMID: 33958113
Smith DK, Sadler KP, Benedum M
Am Fam Physician 2019 Apr 1;99(7):445-450. PMID: 30932454
Abuhandan M, Calik M, Taskin A, Yetkin I, Selek S, Iscan A
J Pak Med Assoc 2013 May;63(5):594-7. PMID: 23757987
Subcommittee on Febrile Seizures; American Academy of Pediatrics
Pediatrics 2011 Feb;127(2):389-94. doi: 10.1542/peds.2010-3318. PMID: 21285335
Warden CR, Zibulewsky J, Mace S, Gold C, Gausche-Hill M
Ann Emerg Med 2003 Feb;41(2):215-22. doi: 10.1067/mem.2003.48. PMID: 12548271

Diagnosis

Ferretti A, Riva A, Fabrizio A, Bruni O, Capovilla G, Foiadelli T, Orsini A, Raucci U, Romeo A, Striano P, Parisi P
Ital J Pediatr 2024 May 12;50(1):95. doi: 10.1186/s13052-024-01666-1. PMID: 38735928Free PMC Article
Smith DK, Sadler KP, Benedum M
Am Fam Physician 2019 Apr 1;99(7):445-450. PMID: 30932454
Abuhandan M, Calik M, Taskin A, Yetkin I, Selek S, Iscan A
J Pak Med Assoc 2013 May;63(5):594-7. PMID: 23757987
Subcommittee on Febrile Seizures; American Academy of Pediatrics
Pediatrics 2011 Feb;127(2):389-94. doi: 10.1542/peds.2010-3318. PMID: 21285335
Warden CR, Zibulewsky J, Mace S, Gold C, Gausche-Hill M
Ann Emerg Med 2003 Feb;41(2):215-22. doi: 10.1067/mem.2003.48. PMID: 12548271

Therapy

Ferretti A, Riva A, Fabrizio A, Bruni O, Capovilla G, Foiadelli T, Orsini A, Raucci U, Romeo A, Striano P, Parisi P
Ital J Pediatr 2024 May 12;50(1):95. doi: 10.1186/s13052-024-01666-1. PMID: 38735928Free PMC Article
Smith DK, Sadler KP, Benedum M
Am Fam Physician 2019 Apr 1;99(7):445-450. PMID: 30932454
Szlam S, Meredith M
Pediatr Emerg Care 2013 Dec;29(12):1287-91; quiz 1292-4. doi: 10.1097/PEC.0000000000000046. PMID: 24300474
Oluwabusi T, Sood SK
Curr Opin Pediatr 2012 Apr;24(2):259-65. doi: 10.1097/MOP.0b013e3283506765. PMID: 22327951
Baumann RJ
Paediatr Drugs 2001;3(8):585-92. doi: 10.2165/00128072-200103080-00003. PMID: 11577923

Prognosis

Ferretti A, Riva A, Fabrizio A, Bruni O, Capovilla G, Foiadelli T, Orsini A, Raucci U, Romeo A, Striano P, Parisi P
Ital J Pediatr 2024 May 12;50(1):95. doi: 10.1186/s13052-024-01666-1. PMID: 38735928Free PMC Article
Falsaperla R, Marino S, Vitaliti G, Bonadies A, Marino SD, Pavone P, Romano C, Savoia F, Calì C, Ruggieri M, Lubrano R, Tipo V
Acta Neurol Belg 2023 Aug;123(4):1339-1344. Epub 2023 Feb 24 doi: 10.1007/s13760-023-02211-3. PMID: 36829088
Smith DK, Sadler KP, Benedum M
Am Fam Physician 2019 Apr 1;99(7):445-450. PMID: 30932454
Capovilla G, Mastrangelo M, Romeo A, Vigevano F
Epilepsia 2009 Jan;50 Suppl 1:2-6. doi: 10.1111/j.1528-1167.2008.01963.x. PMID: 19125841
Warden CR, Zibulewsky J, Mace S, Gold C, Gausche-Hill M
Ann Emerg Med 2003 Feb;41(2):215-22. doi: 10.1067/mem.2003.48. PMID: 12548271

Clinical prediction guides

Falsaperla R, Marino S, Vitaliti G, Bonadies A, Marino SD, Pavone P, Romano C, Savoia F, Calì C, Ruggieri M, Lubrano R, Tipo V
Acta Neurol Belg 2023 Aug;123(4):1339-1344. Epub 2023 Feb 24 doi: 10.1007/s13760-023-02211-3. PMID: 36829088
Liu Z, Li X, Zhang M, Huang X, Bai J, Pan Z, Lin X, Yu D, Zeng H, Wan R, Ye X
Sci Rep 2018 Oct 11;8(1):15123. doi: 10.1038/s41598-018-33373-3. PMID: 30310107Free PMC Article
Chan S, Bello JA, Shinnar S, Hesdorffer DC, Lewis DV, MacFall J, Shinnar RC, Gomes W, Litherland C, Xu Y, Nordli DR, Pellock JM, Frank LM, Moshé SL, Sun S; FEBSTAT Study Team
AJR Am J Roentgenol 2015 Nov;205(5):1068-74. doi: 10.2214/AJR.14.13330. PMID: 26496555Free PMC Article
Shrestha D, Dhakal AK, Shakya H, Shakya A, Shah SC, Mehata S
J Nepal Health Res Counc 2014 Sep-Oct;12(28):162-6. PMID: 26032052
Goksugur SB, Kabakus N, Bekdas M, Demircioglu F
Eur Rev Med Pharmacol Sci 2014 Nov;18(22):3380-5. PMID: 25491611

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