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Mononeuritis multiplex

MedGen UID:
101790
Concept ID:
C0151295
Disease or Syndrome
Synonym: Mononeuritis Multiplex
SNOMED CT: Mononeuritis multiplex (30292005)
 
HPO: HP:0032018
Monarch Initiative: MONDO:0002128

Definition

A type of peripheral neuropathy that happens when there is damage to two or more different nerve areas characterized by peripheral neuropathy of both the motor and sensory nerves of at least two different nerve trunks. Different nerves are affected either simultaneously or sequentially. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMononeuritis multiplex

Conditions with this feature

Granulomatosis with polyangiitis
MedGen UID:
811223
Concept ID:
C3495801
Disease or Syndrome
Granulomatosis with polyangiitis, formerly termed Wegener granulomatosis, is a systemic disease with a complex genetic background. It is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis, vasculitis, and the presence of antineutrophil cytoplasmatic autoantibodies (ANCAs) in patient sera. These ANCAs are antibodies to a defined target antigen, proteinase-3 (PR3, PRTN3; 177020), which is present within primary azurophil granules of neutrophils (PMNs) and lysozymes of monocytes. On cytokine priming of PMNs, PR3 translocates to the cell surface, where PR3-ANCAs can interact with their antigens and activate PMNs. PMNs from patients with active GPA express PR3 on their surface, produce respiratory burst, and release proteolytic enzymes after activation with PR3-ANCAs. The consequence is a self-sustaining inflammatory process (Jagiello et al., 2004).

Professional guidelines

PubMed

Grayson PC, Ponte C, Suppiah R, Robson JC, Craven A, Judge A, Khalid S, Hutchings A, Luqmani RA, Watts RA, Merkel PA; DCVAS Study Group
Arthritis Rheumatol 2022 Mar;74(3):386-392. Epub 2022 Feb 2 doi: 10.1002/art.41982. PMID: 35106968
Trivioli G, Terrier B, Vaglio A
Rheumatology (Oxford) 2020 May 1;59(Suppl 3):iii84-iii94. doi: 10.1093/rheumatology/kez570. PMID: 32348510
Vargas DL, Stern BJ
Semin Respir Crit Care Med 2010 Aug;31(4):419-27. Epub 2010 Jul 27 doi: 10.1055/s-0030-1262210. PMID: 20665392

Recent clinical studies

Etiology

Taga A, Lauria G
J Peripher Nerv Syst 2022 Mar;27(1):4-30. Epub 2022 Mar 14 doi: 10.1111/jns.12482. PMID: 35137496Free PMC Article
Grayson PC, Ponte C, Suppiah R, Robson JC, Craven A, Judge A, Khalid S, Hutchings A, Luqmani RA, Watts RA, Merkel PA; DCVAS Study Group
Ann Rheum Dis 2022 Mar;81(3):309-314. Epub 2022 Feb 2 doi: 10.1136/annrheumdis-2021-221794. PMID: 35110334
Grayson PC, Ponte C, Suppiah R, Robson JC, Craven A, Judge A, Khalid S, Hutchings A, Luqmani RA, Watts RA, Merkel PA; DCVAS Study Group
Arthritis Rheumatol 2022 Mar;74(3):386-392. Epub 2022 Feb 2 doi: 10.1002/art.41982. PMID: 35106968
Pavlakis PP
Continuum (Minneap Minn) 2020 Jun;26(3):591-610. doi: 10.1212/CON.0000000000000856. PMID: 32487898
Cacoub P, Comarmond C, Domont F, Savey L, Saadoun D
Am J Med 2015 Sep;128(9):950-5. Epub 2015 Mar 30 doi: 10.1016/j.amjmed.2015.02.017. PMID: 25837517

Diagnosis

Grayson PC, Ponte C, Suppiah R, Robson JC, Craven A, Judge A, Khalid S, Hutchings A, Luqmani RA, Watts RA, Merkel PA; DCVAS Study Group
Ann Rheum Dis 2022 Mar;81(3):309-314. Epub 2022 Feb 2 doi: 10.1136/annrheumdis-2021-221794. PMID: 35110334
Grayson PC, Ponte C, Suppiah R, Robson JC, Craven A, Judge A, Khalid S, Hutchings A, Luqmani RA, Watts RA, Merkel PA; DCVAS Study Group
Arthritis Rheumatol 2022 Mar;74(3):386-392. Epub 2022 Feb 2 doi: 10.1002/art.41982. PMID: 35106968
Trivioli G, Terrier B, Vaglio A
Rheumatology (Oxford) 2020 May 1;59(Suppl 3):iii84-iii94. doi: 10.1093/rheumatology/kez570. PMID: 32348510
Cacoub P, Comarmond C, Domont F, Savey L, Saadoun D
Am J Med 2015 Sep;128(9):950-5. Epub 2015 Mar 30 doi: 10.1016/j.amjmed.2015.02.017. PMID: 25837517
Vrancken AF, Said G
Handb Clin Neurol 2013;115:463-83. doi: 10.1016/B978-0-444-52902-2.00026-6. PMID: 23931796

Therapy

Barile-Fabris L, Hernández-Cabrera MF, Barragan-Garfias JA
Curr Rheumatol Rep 2014;16(9):440. doi: 10.1007/s11926-014-0440-9. PMID: 25023725
Cacoub P, Terrier B, Saadoun D
Ann Rheum Dis 2014 Jan;73(1):24-30. Epub 2013 Aug 6 doi: 10.1136/annrheumdis-2013-203883. PMID: 23921995
Nobile-Orazio E, Gallia F
Drugs 2013 Apr;73(5):397-406. doi: 10.1007/s40265-013-0029-z. PMID: 23516024
Vargas DL, Stern BJ
Semin Respir Crit Care Med 2010 Aug;31(4):419-27. Epub 2010 Jul 27 doi: 10.1055/s-0030-1262210. PMID: 20665392
Dalakas MC, Cupler EJ
Baillieres Clin Neurol 1996 Mar;5(1):199-218. PMID: 8732208

Prognosis

Cacoub P, Comarmond C, Domont F, Savey L, Saadoun D
Am J Med 2015 Sep;128(9):950-5. Epub 2015 Mar 30 doi: 10.1016/j.amjmed.2015.02.017. PMID: 25837517
Ugalde V, Rosen BS
Phys Med Rehabil Clin N Am 2001 May;12(2):365-80. PMID: 11345013
Dalakas MC, Cupler EJ
Baillieres Clin Neurol 1996 Mar;5(1):199-218. PMID: 8732208
Davies L
Baillieres Clin Neurol 1994 Apr;3(1):193-210. PMID: 7921589
Nelson KR, McQuillen MP
Neurol Clin 1988 May;6(2):389-403. PMID: 3047548

Clinical prediction guides

Grayson PC, Ponte C, Suppiah R, Robson JC, Craven A, Judge A, Khalid S, Hutchings A, Luqmani RA, Watts RA, Merkel PA; DCVAS Study Group
Ann Rheum Dis 2022 Mar;81(3):309-314. Epub 2022 Feb 2 doi: 10.1136/annrheumdis-2021-221794. PMID: 35110334
Grayson PC, Ponte C, Suppiah R, Robson JC, Craven A, Judge A, Khalid S, Hutchings A, Luqmani RA, Watts RA, Merkel PA; DCVAS Study Group
Arthritis Rheumatol 2022 Mar;74(3):386-392. Epub 2022 Feb 2 doi: 10.1002/art.41982. PMID: 35106968
Mouthon L, Dunogue B, Guillevin L
J Autoimmun 2014 Feb-Mar;48-49:99-103. Epub 2014 Feb 12 doi: 10.1016/j.jaut.2014.01.018. PMID: 24530234
Chai J, Logigian EL
Curr Opin Neurol 2010 Oct;23(5):509-13. doi: 10.1097/WCO.0b013e32833de6ab. PMID: 20689426
Nelson KR, McQuillen MP
Neurol Clin 1988 May;6(2):389-403. PMID: 3047548

Recent systematic reviews

Humă AC, Kecskeş EM, Tulbă D, Bălănescu P, Băicuş C
Rom J Intern Med 2020 Mar 1;58(1):5-12. doi: 10.2478/rjim-2019-0022. PMID: 31527298
Garzoni L, Vanoni F, Rizzi M, Simonetti GD, Goeggel Simonetti B, Ramelli GP, Bianchetti MG
Rheumatology (Oxford) 2009 Dec;48(12):1524-9. Epub 2009 Sep 21 doi: 10.1093/rheumatology/kep282. PMID: 19797041

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