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Hypotropia

MedGen UID:
101826
Concept ID:
C0152208
Disease or Syndrome
Synonyms: Downward Ocular Deviation; downward ocular deviation; hyop - Hypotropia; hypotropia; Sunset Sign; sunset sign
SNOMED CT: hyop - Hypotropia (29491004); Hypotropia (29491004)
 
HPO: HP:0025584
Monarch Initiative: MONDO:0004897

Definition

A form of manifest strabismus (heterotropia) in which one eye is deviated downwards when both eyes are open. [from HPO]

Term Hierarchy

Conditions with this feature

Fibrosis of extraocular muscles, congenital, 2
MedGen UID:
356119
Concept ID:
C1865915
Disease or Syndrome
Congenital fibrosis of extraocular muscles-2 (CFEOM2) is an autosomal recessive disorder in which affected individuals are born with bilateral ptosis and restrictive ophthalmoplegia with the globes fixed in extreme abduction (exotropia) (Wang et al., 1998, Nakano et al., 2001). For a general phenotypic description and a discussion of genetic heterogeneity of various forms of CFEOM, see CFEOM1 (135700).
Ophthalmoplegia, external, with rib and vertebral anomalies
MedGen UID:
1648445
Concept ID:
C4748418
Disease or Syndrome
External ophthalmoplegia with rib and vertebral anomalies (EORVA) is characterized by congenital nonprogressive external ophthalmoplegia and ptosis, with torticollis and scoliosis developing during childhood. In addition, patients exhibit hypoplastic or missing ribs with fusion anomalies (Di Gioia et al., 2018).

Professional guidelines

PubMed

Merino P, Antón V, Chamorro M, Gómez de Liaño P, Yáñez-Merino J
Arch Soc Esp Oftalmol (Engl Ed) 2023 Oct;98(10):553-557. Epub 2023 Aug 28 doi: 10.1016/j.oftale.2023.06.021. PMID: 37648208
Lin Q, Man F, Wang N, Chen T, Yu G, Wang Z, Chang Q, Jiao Y, Zhao K
J AAPOS 2011 Feb;15(1):5-8. doi: 10.1016/j.jaapos.2010.09.019. PMID: 21397798
Wright KW
Trans Am Ophthalmol Soc 1999;97:1023-109. PMID: 10703149Free PMC Article

Recent clinical studies

Etiology

Bhate M, Adewara B, Bothra N
Indian J Ophthalmol 2023 Mar;71(3):973-976. doi: 10.4103/ijo.IJO_1929_22. PMID: 36872720Free PMC Article
Nadeem S
Int Ophthalmol 2022 Oct;42(10):3165-3181. Epub 2022 May 18 doi: 10.1007/s10792-022-02316-3. PMID: 35583684
Kim JY, Yang HK, Kim N, Kim MJ, Cho SI, Seong MW, Park SS, Hwang JM
Acta Ophthalmol 2021 Mar;99(2):e274-e280. Epub 2020 Nov 15 doi: 10.1111/aos.14558. PMID: 33191655
Robbins L, Goseki T, Law SK, Nouri-Mahdavi K, Caprioli J, Coleman AL, Giaconi JA, Demer JL, Velez FG, Pineles SL
Am J Ophthalmol 2021 Feb;222:1-5. Epub 2020 Aug 17 doi: 10.1016/j.ajo.2020.08.019. PMID: 32818449
Lin Q, Man F, Wang N, Chen T, Yu G, Wang Z, Chang Q, Jiao Y, Zhao K
J AAPOS 2011 Feb;15(1):5-8. doi: 10.1016/j.jaapos.2010.09.019. PMID: 21397798

Diagnosis

Senda J, Hirao R, Maeda K, Amakusa Y, Hirunagi T, Katsuno M, Kawaguchi K
Nagoya J Med Sci 2023 Nov;85(4):822-827. doi: 10.18999/nagjms.85.4.822. PMID: 38155615Free PMC Article
Hou P, Liu L, Yang G
J AAPOS 2023 Aug;27(4):231-233. Epub 2023 Jun 21 doi: 10.1016/j.jaapos.2023.05.001. PMID: 37348674
Nadeem S
Int Ophthalmol 2022 Oct;42(10):3165-3181. Epub 2022 May 18 doi: 10.1007/s10792-022-02316-3. PMID: 35583684
Matalia J, Anaspure H, Panmand P, Kowal L
J AAPOS 2014 Oct;18(5):498-500. Epub 2014 Sep 27 doi: 10.1016/j.jaapos.2014.06.015. PMID: 25266837
Lin Q, Man F, Wang N, Chen T, Yu G, Wang Z, Chang Q, Jiao Y, Zhao K
J AAPOS 2011 Feb;15(1):5-8. doi: 10.1016/j.jaapos.2010.09.019. PMID: 21397798

Therapy

Senda J, Hirao R, Maeda K, Amakusa Y, Hirunagi T, Katsuno M, Kawaguchi K
Nagoya J Med Sci 2023 Nov;85(4):822-827. doi: 10.18999/nagjms.85.4.822. PMID: 38155615Free PMC Article
Robbins L, Goseki T, Law SK, Nouri-Mahdavi K, Caprioli J, Coleman AL, Giaconi JA, Demer JL, Velez FG, Pineles SL
Am J Ophthalmol 2021 Feb;222:1-5. Epub 2020 Aug 17 doi: 10.1016/j.ajo.2020.08.019. PMID: 32818449
Chang MY, Coleman AL, Tseng VL, Demer JL
Cochrane Database Syst Rev 2017 Nov 27;11(11):CD012447. doi: 10.1002/14651858.CD012447.pub2. PMID: 29178265Free PMC Article
Hatt SR, Wang X, Holmes JM
Cochrane Database Syst Rev 2015 Nov 20;2015(11):CD010868. doi: 10.1002/14651858.CD010868.pub2. PMID: 26587695Free PMC Article
Kushner BJ
Arch Ophthalmol 2007 Nov;125(11):1510-4. doi: 10.1001/archopht.125.11.1510. PMID: 17998512

Prognosis

Ha SG, Kim SH
J Pediatr Ophthalmol Strabismus 2021 Jan 1;58(1):23-27. doi: 10.3928/01913913-20200910-04. PMID: 33495794
Robbins L, Goseki T, Law SK, Nouri-Mahdavi K, Caprioli J, Coleman AL, Giaconi JA, Demer JL, Velez FG, Pineles SL
Am J Ophthalmol 2021 Feb;222:1-5. Epub 2020 Aug 17 doi: 10.1016/j.ajo.2020.08.019. PMID: 32818449
Serafino M, Scaramuzzi M, Villani E, Nucci P
Eur J Ophthalmol 2020 Jul;30(4):676-679. Epub 2019 May 20 doi: 10.1177/1120672119850684. PMID: 31106643
Ganesh SC DO DNB, Jayadev NA MS, Oguego N M Ophthal, Narendran K DO DNB, Rao SG MS
Strabismus 2019 Dec;27(4):223-229. Epub 2019 Oct 15 doi: 10.1080/09273972.2019.1676794. PMID: 31612771
Dotan G, Eiger-Moscovich M, Snir M, Ehrenberg M, Friling R
J Pediatr Ophthalmol Strabismus 2018 Mar 1;55(2):113-116. Epub 2017 Dec 19 doi: 10.3928/01913913-20171101-02. PMID: 29257185

Clinical prediction guides

Khorrami-Nejad M, Akbari MR, Azizi E, Fareed Tarik F, Yousefi R, Masoomian B
Clin Exp Optom 2024 Aug;107(6):622-626. Epub 2023 Sep 27 doi: 10.1080/08164622.2023.2256323. PMID: 37759378
Gim Y, Jung JH
J AAPOS 2023 Aug;27(4):205.e1-205.e6. Epub 2023 Jul 8 doi: 10.1016/j.jaapos.2023.06.001. PMID: 37429539
Bhate M, Adewara B, Bothra N
Indian J Ophthalmol 2023 Mar;71(3):973-976. doi: 10.4103/ijo.IJO_1929_22. PMID: 36872720Free PMC Article
Serafino M, Scaramuzzi M, Villani E, Nucci P
Eur J Ophthalmol 2020 Jul;30(4):676-679. Epub 2019 May 20 doi: 10.1177/1120672119850684. PMID: 31106643
Chang MY, Coleman AL, Tseng VL, Demer JL
Cochrane Database Syst Rev 2017 Nov 27;11(11):CD012447. doi: 10.1002/14651858.CD012447.pub2. PMID: 29178265Free PMC Article

Recent systematic reviews

Van Swol JM, Myers WK, Nguyen SA, Wilson ME
J Binocul Vis Ocul Motil 2023 Apr-Jun;73(2):43-52. Epub 2023 Feb 13 PMID: 36780505
Chang MY, Coleman AL, Tseng VL, Demer JL
Cochrane Database Syst Rev 2017 Nov 27;11(11):CD012447. doi: 10.1002/14651858.CD012447.pub2. PMID: 29178265Free PMC Article
Hatt SR, Wang X, Holmes JM
Cochrane Database Syst Rev 2015 Nov 20;2015(11):CD010868. doi: 10.1002/14651858.CD010868.pub2. PMID: 26587695Free PMC Article

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