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Benign neoplasm of scrotum

MedGen UID:
102302
•Concept ID:
C0154011
•
Neoplastic Process
Synonyms: Benign Neoplasm of Scrotum; benign neoplasm of scrotum; Benign Neoplasm of the Scrotum; benign neoplasm of the scrotum; Benign Scrotal Neoplasm; benign scrotal neoplasm; Benign Scrotal Tumor; benign scrotal tumor; benign scrotal tumour; Benign Tumor of Scrotum; benign tumor of scrotum; Benign Tumor of the Scrotum; benign tumor of the scrotum; benign tumour of scrotum; benign tumour of the scrotum; scrotum benign neoplasm
SNOMED CT: Benign neoplasm of scrotum (92336000)
 
Monarch Initiative: MONDO:0021472

Definition

A neoplasm that arises from the scrotum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of scrotum

Professional guidelines

PubMed

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Surgical management and gynecologic care of the transgender patient.
Schmidt M, Ditrio L, Shute B, Luciano D
Curr Opin Obstet Gynecol 2019 Aug;31(4):228-234. doi: 10.1097/GCO.0000000000000553. PMID: 31045656
Diagnosis and management of spermatic cord tumors.
Moschini M, Mattei A
Curr Opin Urol 2017 Jan;27(1):76-79. doi: 10.1097/MOU.0000000000000318. PMID: 27262142

Recent clinical studies

Etiology

The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
Updates in Staging and Reporting of Testicular Cancer.
Magers MJ, Idrees MT
Surg Pathol Clin 2018 Dec;11(4):813-824. doi: 10.1016/j.path.2018.07.005. PMID: 30447843
Primary testicular leiomyosarcoma.
Bostanci Y, Ozden E, Akdeniz E, Kazzazi A, Kandemir B, Yakupoglu YK, Djavan B
Can J Urol 2013 Apr;20(2):6730-3. PMID: 23587515
Scrotal lymphangioma.
Yasui T, Akita H, Kobayashi K, Kohri K
Urol Int 1998;61(3):178-80. doi: 10.1159/000030318. PMID: 9933841
Undescended testis and testicular torsion.
Sheldon CA
Surg Clin North Am 1985 Oct;65(5):1303-29. doi: 10.1016/s0039-6109(16)43741-2. PMID: 2865826

Diagnosis

Pilonidal Disease of the Scrotum.
Winter K, Warren MC Jr, Nelson EC, Young W
Am Surg 2023 Dec;89(12):6320. Epub 2023 Apr 28 doi: 10.1177/00031348231174006. PMID: 37118848
Hydrocele with Paratesticular Liposarcoma.
Baran O, Bozkurt U, Aykac A
J Coll Physicians Surg Pak 2022 Apr;32(4):S1-S2. doi: 10.29271/jcpsp.2022.Supp1.S1. PMID: 35632994
Penoscrotal Paget's disease.
Dauendorffer JN, Herms F, Baroudjian B, Basset-Seguin N, Cavelier-Balloy B, Fouéré S, Bagot M, Lebbé C
Ann Dermatol Venereol 2021 Jun;148(2):71-76. Epub 2021 Jan 16 doi: 10.1016/j.annder.2020.08.051. PMID: 33461789
Scrotal imaging.
Watanabe Y
Curr Opin Urol 2002 Mar;12(2):149-53. doi: 10.1097/00042307-200203000-00012. PMID: 11859263
Paratesticular myxoma.
Yoshimura K, Inoue H, Koide T, Ohnishi S
Urol Int 1994;52(4):231-2. doi: 10.1159/000282617. PMID: 8030175

Therapy

Topical timolol in dermatology: infantile haemangiomas and beyond.
Alzaid M, Al-Naseem A, Al-Niaimi F, Ali FR
Clin Exp Dermatol 2022 May;47(5):819-832. Epub 2022 Jan 13 doi: 10.1111/ced.15021. PMID: 34798680
The role of multiparametric ultrasound in the diagnosis of paediatric scrotal pathology.
Huang DY, Pesapane F, Rafailidis V, Deganello A, Sellars ME, Sidhu PS
Br J Radiol 2020 Jun;93(1110):20200063. Epub 2020 Apr 23 doi: 10.1259/bjr.20200063. PMID: 32271626Free PMC Article
Scrotal Ulceration and Pyrexia.
Foley CC, Marren P
JAMA Dermatol 2017 Nov 1;153(11):1181-1182. doi: 10.1001/jamadermatol.2017.2559. PMID: 28724120
Radioprotective reverse orchidopexy.
Okoye BO, Spooner D, Townley JF, Gornall P
J Pediatr Surg 2002 Feb;37(2):236-9. doi: 10.1053/jpsu.2002.30262. PMID: 11819206
Acute scrotal pathology.
Sharer WC
Surg Clin North Am 1982 Dec;62(6):955-70. doi: 10.1016/s0039-6109(16)42877-x. PMID: 6294890

Prognosis

Testicular self-examination for early detection of testicular cancer.
Chong RIH, Leow JJ, Choo ZW, Salada R, Yong DZP, Chong YL
World J Urol 2023 Apr;41(4):941-951. Epub 2023 Apr 10 doi: 10.1007/s00345-023-04381-4. PMID: 37036497
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Primary testicular leiomyosarcoma.
Bostanci Y, Ozden E, Akdeniz E, Kazzazi A, Kandemir B, Yakupoglu YK, Djavan B
Can J Urol 2013 Apr;20(2):6730-3. PMID: 23587515
Rhabdomyosarcoma metastatic paratesticular.
Zorzo OH, Gomez MF, Abuin JM, Lumbreras PE, Plaza PA, Vicente AG, Rodriguez AM, Avisrror MU
Arch Esp Urol 2009 Sep;62(7):599-602. PMID: 20306589

Clinical prediction guides

Scrotal Masses.
Langan RC, Puente MEE
Am Fam Physician 2022 Aug;106(2):184-189. PMID: 35977130
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Giant Angiofibroma of the Scrotum in a Child.
Arena S, Barresi V, Romeo C
Urology 2016 Jul;93:e15-6. Epub 2016 Mar 30 doi: 10.1016/j.urology.2016.03.031. PMID: 27038983
Cryptorchidism.
Hutson JM, Balic A, Nation T, Southwell B
Semin Pediatr Surg 2010 Aug;19(3):215-24. doi: 10.1053/j.sempedsurg.2010.04.001. PMID: 20610195
Malignant mesothelioma of testicular tunica vaginalis.
Abe K, Kato N, Miki K, Nimura S, Suzuki M, Kiyota H, Onodera S, Oishi Y
Int J Urol 2002 Oct;9(10):602-3. doi: 10.1046/j.1442-2042.2002.00521.x. PMID: 12445242

Recent systematic reviews

A systematic review of basal cell carcinoma on the scrotum-reviewing presentation and identifying challenges in management.
Demirci MA, Wan L, Park A, Khachemoune A
Arch Dermatol Res 2024 May 25;316(6):255. doi: 10.1007/s00403-024-03058-1. PMID: 38795216
Radiological features characterising indeterminate testes masses: a systematic review and meta-analysis.
Ager M, Donegan S, Boeri L, de Castro JM, Donaldson JF, Omar MI, Dimitropoulos K, Tharakan T, Janisch F, Muilwijk T, Yuan C, Tudur-Smith C, Nijman RJM, Radmayr C, Salonia A, Laguna Pes MP, Minhas S
BJU Int 2023 Mar;131(3):288-300. Epub 2022 Oct 9 doi: 10.1111/bju.15869. PMID: 35980855
Systematic Review of Surgical Treatment and Outcomes After Local Surgery of Primary Cutaneous Melanomas of the Penis and Scrotum.
Bittar JM, Bittar PG, Wan MT, Kovell RC, Guzzo TJ, Shin TM, Etzkorn JR, Sobanko JF, Miller CJ
Dermatol Surg 2018 Sep;44(9):1159-1169. doi: 10.1097/DSS.0000000000001579. PMID: 29985865
Scrotal Melanoma: A Systematic Review of Presentation, Treatment, and Outcomes.
Zikry J, Chapman LW, Korta DZ, Smith J
Dermatol Surg 2017 Jun;43(6):765-770. doi: 10.1097/DSS.0000000000001072. PMID: 28291064
Adult inguinoscrotal sarcomas: outcome analysis of 21 cases, systematic review of the literature and meta-analysis.
Froehner M, Koch R, Lossnitzer A, Schober RR, Schuler M, Wirth MP
World J Urol 2014 Apr;32(2):445-51. Epub 2013 Jul 9 doi: 10.1007/s00345-013-1124-1. PMID: 23836016

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