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Cicatricial ectropion

MedGen UID:
102327
Concept ID:
C0155196
Disease or Syndrome
Synonym: cicatricial ectropion
SNOMED CT: Cicatricial ectropion (28914006)
 
HPO: HP:0025608
Monarch Initiative: MONDO:0001582

Definition

An outward turning (eversion) or rotation of the eyelid margin (i.e., ectropion) caused by shortening or contraction of the anterior or middle lamellae related to scarring. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCicatricial ectropion

Conditions with this feature

Tangier disease
MedGen UID:
52644
Concept ID:
C0039292
Disease or Syndrome
Tangier disease is characterized by severe deficiency or absence of high-density lipoprotein (HDL) in the circulation resulting in tissue accumulation of cholesteryl esters throughout the body, particularly in the reticuloendothelial system. The major clinical signs of Tangier disease include hyperplastic yellow-orange tonsils, hepatosplenomegaly, and peripheral neuropathy, which may be either relapsing-remitting or chronic progressive in nature. Rarer complications may include corneal opacities that typically do not affect vision, premature atherosclerotic coronary artery disease occurring in the sixth and seventh decades of life (not usually before age 40 years), and mild hematologic manifestations, such as mild thrombocytopenia, reticulocytosis, stomatocytosis, or hemolytic anemia. The clinical expression of Tangier disease is variable, with some affected individuals only showing biochemical perturbations.

Professional guidelines

PubMed

Ouyang HW, Gold MH, Lei Y, Tan J
J Cosmet Dermatol 2021 Jan;20(1):84-92. Epub 2020 Nov 16 doi: 10.1111/jocd.13821. PMID: 33124092
Romero R, Sanchez-Orgaz M, Granados M, Arbizu A, Castano A, Romero A, Molia P
Orbit 2013 Dec;32(6):362-5. Epub 2013 Sep 24 doi: 10.3109/01676830.2013.833250. PMID: 24063354
Fezza JP
Plast Reconstr Surg 2008 Mar;121(3):1009-1014. doi: 10.1097/01.prs.0000299382.31856.d8. PMID: 18317150

Recent clinical studies

Etiology

Nghiem AZ, Ameen M, Koutroumanos N
Int Ophthalmol 2023 Dec;43(12):4791-4795. Epub 2023 Oct 16 doi: 10.1007/s10792-023-02880-2. PMID: 37843763
Vahdani K, Thaller VT
Eye (Lond) 2021 Mar;35(3):929-935. Epub 2020 Jun 3 doi: 10.1038/s41433-020-0998-6. PMID: 32494043Free PMC Article
Goddard L, Chesnut C
Dermatol Surg 2019 Jul;45(7):898-905. doi: 10.1097/DSS.0000000000001757. PMID: 30614837
McKelvie J, Papchenko T, Carroll S, Ng SG
Clin Exp Ophthalmol 2018 Dec;46(9):1002-1007. Epub 2018 Jul 8 doi: 10.1111/ceo.13338. PMID: 29920894
Lupo F, Ioppolo L, Pino D, Meduri A, d'Alcontres FS, R Colonna M, Delia G
Ann Ital Chir 2016;87:466-469. PMID: 27842016

Diagnosis

Nghiem AZ, Ameen M, Koutroumanos N
Int Ophthalmol 2023 Dec;43(12):4791-4795. Epub 2023 Oct 16 doi: 10.1007/s10792-023-02880-2. PMID: 37843763
McKelvie J, Papchenko T, Carroll S, Ng SG
Clin Exp Ophthalmol 2018 Dec;46(9):1002-1007. Epub 2018 Jul 8 doi: 10.1111/ceo.13338. PMID: 29920894
Balogun BG, Adekoya BJ, Balogun MM, Ngwu RV, Oworu O
Ann Afr Med 2013 Oct-Dec;12(4):193-6. doi: 10.4103/1596-3519.122682. PMID: 24309406
Bedran EG, Pereira MV, Bernardes TF
Semin Ophthalmol 2010 May;25(3):59-65. doi: 10.3109/08820538.2010.488570. PMID: 20590414
Piskiniene R
Medicina (Kaunas) 2006;42(11):881-4. PMID: 17172788

Therapy

Mangan MS
Turk J Ophthalmol 2022 Feb 23;52(1):72-74. doi: 10.4274/tjo.galenos.2021.73004. PMID: 35196844Free PMC Article
Ouyang HW, Gold MH, Lei Y, Tan J
J Cosmet Dermatol 2021 Jan;20(1):84-92. Epub 2020 Nov 16 doi: 10.1111/jocd.13821. PMID: 33124092
Goddard L, Chesnut C
Dermatol Surg 2019 Jul;45(7):898-905. doi: 10.1097/DSS.0000000000001757. PMID: 30614837
Nicoli F, Orfaniotis G, Ciudad P, Maruccia M, Lazzeri D, Costabile L, Li K, Zhang YX, Cervelli V, Balzani A
Lasers Med Sci 2019 Feb;34(1):79-84. Epub 2018 Jul 28 doi: 10.1007/s10103-018-2601-y. PMID: 30056585
Romero R, Sanchez-Orgaz M, Granados M, Arbizu A, Castano A, Romero A, Molia P
Orbit 2013 Dec;32(6):362-5. Epub 2013 Sep 24 doi: 10.3109/01676830.2013.833250. PMID: 24063354

Prognosis

Behera G, Sangaraju S, Meethale Thiruvoth F, Kasturi N, Babu KR
J Burn Care Res 2021 Aug 4;42(4):836-838. doi: 10.1093/jbcr/irab027. PMID: 33528555
Christensen JM, Shanbhag SS, Shih GC, Goverman J, Pomahac B, Chodosh J, Ehrlichman RJ
J Burn Care Res 2020 Jul 3;41(4):859-865. doi: 10.1093/jbcr/irz201. PMID: 31808803
Nicoli F, Orfaniotis G, Ciudad P, Maruccia M, Lazzeri D, Costabile L, Li K, Zhang YX, Cervelli V, Balzani A
Lasers Med Sci 2019 Feb;34(1):79-84. Epub 2018 Jul 28 doi: 10.1007/s10103-018-2601-y. PMID: 30056585
McKelvie J, Papchenko T, Carroll S, Ng SG
Clin Exp Ophthalmol 2018 Dec;46(9):1002-1007. Epub 2018 Jul 8 doi: 10.1111/ceo.13338. PMID: 29920894
Lupo F, Ioppolo L, Pino D, Meduri A, d'Alcontres FS, R Colonna M, Delia G
Ann Ital Chir 2016;87:466-469. PMID: 27842016

Clinical prediction guides

Ouyang HW, Gold MH, Lei Y, Tan J
J Cosmet Dermatol 2021 Jan;20(1):84-92. Epub 2020 Nov 16 doi: 10.1111/jocd.13821. PMID: 33124092
Worley B, Huang JW, Macdonald J
Arch Dermatol Res 2020 Apr;312(3):165-172. Epub 2019 Oct 4 doi: 10.1007/s00403-019-01983-0. PMID: 31584117
Nicoli F, Orfaniotis G, Ciudad P, Maruccia M, Lazzeri D, Costabile L, Li K, Zhang YX, Cervelli V, Balzani A
Lasers Med Sci 2019 Feb;34(1):79-84. Epub 2018 Jul 28 doi: 10.1007/s10103-018-2601-y. PMID: 30056585
Li XQ, Wang JQ
J Craniofac Surg 2016 Jan;27(1):70-3. doi: 10.1097/SCS.0000000000002262. PMID: 26674895
Custer PL, Kent TL
Ophthalmic Plast Reconstr Surg 2016 Mar-Apr;32(2):102-5. doi: 10.1097/IOP.0000000000000431. PMID: 25719374

Recent systematic reviews

Worley B, Huang JW, Macdonald J
Arch Dermatol Res 2020 Apr;312(3):165-172. Epub 2019 Oct 4 doi: 10.1007/s00403-019-01983-0. PMID: 31584117

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