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Microvascular complications of diabetes, susceptibility

MedGen UID:
1034754
•Concept ID:
CN357508
•
Disease or Syndrome
Synonym: Microvascular complications of diabetes
 
Related genes: VEGFA, SOD2, PON1, IL1RN, EPO, ACE
 
Monarch Initiative: MONDO:0000065
OMIM® Phenotypic series: PS603933

Professional guidelines

PubMed

Current landscape and comprehensive management of glycemic variability in diabetic retinopathy.
Chen B, Shen C, Sun B
J Transl Med 2024 Jul 29;22(1):700. doi: 10.1186/s12967-024-05516-w. PMID: 39075573Free PMC Article
Identifying Genetic Risk Factors for Diabetic Macular Edema and the Response to Treatment.
Gurung RL, FitzGerald LM, McComish BJ, Verma N, Burdon KP
J Diabetes Res 2020;2020:5016916. Epub 2020 Nov 12 doi: 10.1155/2020/5016916. PMID: 33274237Free PMC Article
Oxidative stress and diabetic retinopathy: development and treatment.
Calderon GD, Juarez OH, Hernandez GE, Punzo SM, De la Cruz ZD
Eye (Lond) 2017 Aug;31(8):1122-1130. Epub 2017 Apr 28 doi: 10.1038/eye.2017.64. PMID: 28452994Free PMC Article

Recent clinical studies

Etiology

Genetics of diabetes-associated microvascular complications.
Lyssenko V, Vaag A
Diabetologia 2023 Sep;66(9):1601-1613. Epub 2023 Jul 14 doi: 10.1007/s00125-023-05964-x. PMID: 37452207Free PMC Article
Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathy.
Dewanjee S, Vallamkondu J, Kalra RS, John A, Reddy PH, Kandimalla R
Ageing Res Rev 2021 Jul;68:101338. Epub 2021 Apr 7 doi: 10.1016/j.arr.2021.101338. PMID: 33838320
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article
Risk factors for type 2 diabetes mellitus.
Fletcher B, Gulanick M, Lamendola C
J Cardiovasc Nurs 2002 Jan;16(2):17-23. doi: 10.1097/00005082-200201000-00003. PMID: 11800065

Diagnosis

Inflammatory and angiogenic biomarkers in diabetic retinopathy.
Kaštelan S, Orešković I, Bišćan F, Kaštelan H, Gverović Antunica A
Biochem Med (Zagreb) 2020 Oct 15;30(3):030502. Epub 2020 Aug 5 doi: 10.11613/BM.2020.030502. PMID: 32774120Free PMC Article
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Lest we forget the microvascular complications of diabetes.
Holt RIG
Diabet Med 2018 Oct;35(10):1307. doi: 10.1111/dme.13807. PMID: 30246343
Ischemia and diabetic neuropathy.
Nukada H
Handb Clin Neurol 2014;126:469-87. doi: 10.1016/B978-0-444-53480-4.00023-0. PMID: 25410240
Diabetic nephropathy--emerging epigenetic mechanisms.
Kato M, Natarajan R
Nat Rev Nephrol 2014 Sep;10(9):517-30. Epub 2014 Jul 8 doi: 10.1038/nrneph.2014.116. PMID: 25003613Free PMC Article

Therapy

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294
Oxidative stress and diabetic retinopathy: development and treatment.
Calderon GD, Juarez OH, Hernandez GE, Punzo SM, De la Cruz ZD
Eye (Lond) 2017 Aug;31(8):1122-1130. Epub 2017 Apr 28 doi: 10.1038/eye.2017.64. PMID: 28452994Free PMC Article
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article
Haptoglobin: basic and clinical aspects.
Levy AP, Asleh R, Blum S, Levy NS, Miller-Lotan R, Kalet-Litman S, Anbinder Y, Lache O, Nakhoul FM, Asaf R, Farbstein D, Pollak M, Soloveichik YZ, Strauss M, Alshiek J, Livshits A, Schwartz A, Awad H, Jad K, Goldenstein H
Antioxid Redox Signal 2010 Feb;12(2):293-304. doi: 10.1089/ars.2009.2793. PMID: 19659435

Prognosis

Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
The impact of diabetes on corneal nerve morphology and ocular surface integrity.
Markoulli M, Flanagan J, Tummanapalli SS, Wu J, Willcox M
Ocul Surf 2018 Jan;16(1):45-57. Epub 2017 Nov 4 doi: 10.1016/j.jtos.2017.10.006. PMID: 29113918
Role of MicroRNAs in Type 2 Diabetes and Associated Vascular Complications.
Banerjee J, Nema V, Dhas Y, Mishra N
Biochimie 2017 Aug;139:9-19. Epub 2017 May 6 doi: 10.1016/j.biochi.2017.05.007. PMID: 28487136
Cytokines in diabetic nephropathy.
Wu CC, Sytwu HK, Lin YF
Adv Clin Chem 2012;56:55-74. doi: 10.1016/b978-0-12-394317-0.00014-5. PMID: 22397028

Clinical prediction guides

Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
The impact of diabetes on corneal nerve morphology and ocular surface integrity.
Markoulli M, Flanagan J, Tummanapalli SS, Wu J, Willcox M
Ocul Surf 2018 Jan;16(1):45-57. Epub 2017 Nov 4 doi: 10.1016/j.jtos.2017.10.006. PMID: 29113918
Role of MicroRNAs in Type 2 Diabetes and Associated Vascular Complications.
Banerjee J, Nema V, Dhas Y, Mishra N
Biochimie 2017 Aug;139:9-19. Epub 2017 May 6 doi: 10.1016/j.biochi.2017.05.007. PMID: 28487136
Cytokines in diabetic nephropathy.
Wu CC, Sytwu HK, Lin YF
Adv Clin Chem 2012;56:55-74. doi: 10.1016/b978-0-12-394317-0.00014-5. PMID: 22397028

Recent systematic reviews

Potential of medicinal plants to ameliorate neovascularization activities in diabetes: A systematic review.
Yong PH, New SY, Azzani M, Wu YS, Chia VV, Ng ZX
Endocr Regul 2023 Jan 1;58(1):26-39. Epub 2024 Feb 12 doi: 10.2478/enr-2024-0004. PMID: 38345496
Clinical and Genetic Characteristics of ABCC8 Nonneonatal Diabetes Mellitus: A Systematic Review.
Li M, Han X, Ji L
J Diabetes Res 2021;2021:9479268. Epub 2021 Sep 30 doi: 10.1155/2021/9479268. PMID: 34631896Free PMC Article
Association between polymorphisms of cytokine genes and diabetic nephropathy: A comprehensive systematic review and meta-analysis.
Wu J, Jiang C, Hua Y, Liu X, You C
Int J Clin Pract 2021 Nov;75(11):e14634. Epub 2021 Aug 8 doi: 10.1111/ijcp.14634. PMID: 34309136
(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article

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