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Microvascular complications of diabetes, susceptibility to, 1(MVCD1)

MedGen UID:
382957
•Concept ID:
C2676832
•
Finding
Synonym: Microvascular complications of diabetes 1
 
Gene (location): VEGFA (6p21.1)
 
Monarch Initiative: MONDO:0011386
OMIM®: 603933

Definition

Any microvascular complications of diabetes, susceptibility in which the cause of the disease is a mutation in the VEGFA gene. [from MONDO]

Professional guidelines

PubMed

Current landscape and comprehensive management of glycemic variability in diabetic retinopathy.
Chen B, Shen C, Sun B
J Transl Med 2024 Jul 29;22(1):700. doi: 10.1186/s12967-024-05516-w. PMID: 39075573Free PMC Article
Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294

Recent clinical studies

Etiology

Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Association of metabolic syndrome and chronic kidney disease.
Scurt FG, Ganz MJ, Herzog C, Bose K, Mertens PR, Chatzikyrkou C
Obes Rev 2024 Jan;25(1):e13649. Epub 2023 Oct 2 doi: 10.1111/obr.13649. PMID: 37783465
Genetics of diabetes-associated microvascular complications.
Lyssenko V, Vaag A
Diabetologia 2023 Sep;66(9):1601-1613. Epub 2023 Jul 14 doi: 10.1007/s00125-023-05964-x. PMID: 37452207Free PMC Article
Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathy.
Dewanjee S, Vallamkondu J, Kalra RS, John A, Reddy PH, Kandimalla R
Ageing Res Rev 2021 Jul;68:101338. Epub 2021 Apr 7 doi: 10.1016/j.arr.2021.101338. PMID: 33838320
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article

Diagnosis

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Importance of Identifying Novel Biomarkers of Microvascular Damage in Type 1 Diabetes.
Marcovecchio ML
Mol Diagn Ther 2020 Oct;24(5):507-515. doi: 10.1007/s40291-020-00483-6. PMID: 32613289
Diabetic Microvascular Complications: Novel Risk Factors, Biomarkers, and Risk Prediction Models.
McKay GJ, Teo BW, Zheng YF, Sambamoorthi U, Sabanayagam C
J Diabetes Res 2016;2016:2172106. Epub 2015 Dec 8 doi: 10.1155/2016/2172106. PMID: 26779541Free PMC Article
Diabetic nephropathy--emerging epigenetic mechanisms.
Kato M, Natarajan R
Nat Rev Nephrol 2014 Sep;10(9):517-30. Epub 2014 Jul 8 doi: 10.1038/nrneph.2014.116. PMID: 25003613Free PMC Article
MicroRNAs and diabetic complications.
Natarajan R, Putta S, Kato M
J Cardiovasc Transl Res 2012 Aug;5(4):413-22. Epub 2012 May 3 doi: 10.1007/s12265-012-9368-5. PMID: 22552970Free PMC Article

Therapy

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article
Diabetes mellitus: novel insights, analysis and interpretation of pathophysiology and complications management with imidazole-containing peptidomimetic antioxidants.
Babizhayev MA, Lankin VZ, Savel'Yeva EL, Deyev AI, Yegorov YE
Recent Pat Drug Deliv Formul 2013 Dec;7(3):216-56. doi: 10.2174/1872211307666131117121058. PMID: 24236935
Haptoglobin: basic and clinical aspects.
Levy AP, Asleh R, Blum S, Levy NS, Miller-Lotan R, Kalet-Litman S, Anbinder Y, Lache O, Nakhoul FM, Asaf R, Farbstein D, Pollak M, Soloveichik YZ, Strauss M, Alshiek J, Livshits A, Schwartz A, Awad H, Jad K, Goldenstein H
Antioxid Redox Signal 2010 Feb;12(2):293-304. doi: 10.1089/ars.2009.2793. PMID: 19659435

Prognosis

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Importance of Identifying Novel Biomarkers of Microvascular Damage in Type 1 Diabetes.
Marcovecchio ML
Mol Diagn Ther 2020 Oct;24(5):507-515. doi: 10.1007/s40291-020-00483-6. PMID: 32613289
The impact of diabetes on corneal nerve morphology and ocular surface integrity.
Markoulli M, Flanagan J, Tummanapalli SS, Wu J, Willcox M
Ocul Surf 2018 Jan;16(1):45-57. Epub 2017 Nov 4 doi: 10.1016/j.jtos.2017.10.006. PMID: 29113918
Diabetic Microvascular Complications: Novel Risk Factors, Biomarkers, and Risk Prediction Models.
McKay GJ, Teo BW, Zheng YF, Sambamoorthi U, Sabanayagam C
J Diabetes Res 2016;2016:2172106. Epub 2015 Dec 8 doi: 10.1155/2016/2172106. PMID: 26779541Free PMC Article

Clinical prediction guides

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
The impact of diabetes on corneal nerve morphology and ocular surface integrity.
Markoulli M, Flanagan J, Tummanapalli SS, Wu J, Willcox M
Ocul Surf 2018 Jan;16(1):45-57. Epub 2017 Nov 4 doi: 10.1016/j.jtos.2017.10.006. PMID: 29113918
Diabetic Microvascular Complications: Novel Risk Factors, Biomarkers, and Risk Prediction Models.
McKay GJ, Teo BW, Zheng YF, Sambamoorthi U, Sabanayagam C
J Diabetes Res 2016;2016:2172106. Epub 2015 Dec 8 doi: 10.1155/2016/2172106. PMID: 26779541Free PMC Article
The role of epigenetics in the pathology of diabetic complications.
Villeneuve LM, Natarajan R
Am J Physiol Renal Physiol 2010 Jul;299(1):F14-25. Epub 2010 May 12 doi: 10.1152/ajprenal.00200.2010. PMID: 20462972Free PMC Article

Recent systematic reviews

Potential of medicinal plants to ameliorate neovascularization activities in diabetes: A systematic review.
Yong PH, New SY, Azzani M, Wu YS, Chia VV, Ng ZX
Endocr Regul 2023 Jan 1;58(1):26-39. Epub 2024 Feb 12 doi: 10.2478/enr-2024-0004. PMID: 38345496
(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article

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