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Third cranial nerve thickening

MedGen UID:
1052658
•Concept ID:
CN377102
•
Finding
Synonym: Oculomotor nerve thickening
 
HPO: HP:6000291

Definition

Increase in diameter of the third cranial nerve (oculomotor nerve). This feature can be observed by magnetic resonance imaging and may be accompanied by contrast enhancement. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThird cranial nerve thickening

Professional guidelines

PubMed

Diagnosis and surgical treatment of unilateral restrictive hypotropia and esotropia.
Lin Q, Man F, Wang N, Chen T, Yu G, Wang Z, Chang Q, Jiao Y, Zhao K
J AAPOS 2011 Feb;15(1):5-8. doi: 10.1016/j.jaapos.2010.09.019. PMID: 21397798

Recent clinical studies

Etiology

Morning Glory Disc Anomaly: Expanding the MR Phenotype.
Firouzabadi FD, Soldatelli MD, Rameh V, Heidary G, Vargas SO, Gonzalez E, Rispoli J, Rahbar R, Robson CD
AJNR Am J Neuroradiol 2024 Aug 9;45(8):1070-1075. doi: 10.3174/ajnr.A8296. PMID: 38991766Free PMC Article
Cavernous Sinus MRI Findings in Inflammatory and Ischemic Oculomotor Cranial Nerve Palsies.
Yunqing W, Shilei C, Yong L, Qing L, Xiaohong S, Jiawei W
J Neuroophthalmol 2024 Jun 1;44(2):236-241. Epub 2023 Sep 25 doi: 10.1097/WNO.0000000000001958. PMID: 37751328Free PMC Article
Special features of superior oblique hypofunction due to tendon abnormalities.
Aleassa M, Le A, Demer JL
Strabismus 2021 Dec;29(4):243-251. Epub 2021 Nov 17 doi: 10.1080/09273972.2021.1987931. PMID: 34787034Free PMC Article
Clinical features of IgG4-related dacryoadenitis.
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Iwasaki S, Chiba K, Setoguchi K, Horiguchi S, Ozaki N
Graefes Arch Clin Exp Ophthalmol 2014 Mar;252(3):491-7. Epub 2013 Dec 7 doi: 10.1007/s00417-013-2541-y. PMID: 24318531
Idiopathic hypertrophic cranial pachymeningitis.
Rojana-udomsart A, Pulkes T, Viranuwatti K, Laothamatas J, Phudhichareonrat S, Witoonpanich R
J Clin Neurosci 2008 Apr;15(4):465-9. Epub 2008 Jan 30 doi: 10.1016/j.jocn.2006.11.020. PMID: 18249120

Diagnosis

Cavernous Sinus MRI Findings in Inflammatory and Ischemic Oculomotor Cranial Nerve Palsies.
Yunqing W, Shilei C, Yong L, Qing L, Xiaohong S, Jiawei W
J Neuroophthalmol 2024 Jun 1;44(2):236-241. Epub 2023 Sep 25 doi: 10.1097/WNO.0000000000001958. PMID: 37751328Free PMC Article
A rare case of orbital myositis.
Yawar B, Malik Z, Naz F
J Ayub Med Coll Abbottabad 2020 Oct-Dec;32(Suppl 1)(4):S706-S708. PMID: 33754537
Clinical features of IgG4-related dacryoadenitis.
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Iwasaki S, Chiba K, Setoguchi K, Horiguchi S, Ozaki N
Graefes Arch Clin Exp Ophthalmol 2014 Mar;252(3):491-7. Epub 2013 Dec 7 doi: 10.1007/s00417-013-2541-y. PMID: 24318531
Granulomatous meningitis.
Loy ST, Tan CW
Singapore Med J 2009 Nov;50(11):e371-3. PMID: 19960146
Ophthalmoplegic migraine.
Bek S, Genc G, Demirkaya S, Eroglu E, Odabasi Z
Neurologist 2009 May;15(3):147-9. doi: 10.1097/NRL.0b013e3181870408. PMID: 19430270

Therapy

Clinical features of IgG4-related dacryoadenitis.
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Iwasaki S, Chiba K, Setoguchi K, Horiguchi S, Ozaki N
Graefes Arch Clin Exp Ophthalmol 2014 Mar;252(3):491-7. Epub 2013 Dec 7 doi: 10.1007/s00417-013-2541-y. PMID: 24318531
Microsurgical findings of Tolosa-Hunt syndrome.
Kodera T, Takeuchi H, Arishima H, Tsunetoshi K, Kitai R, Arai Y, Kikuta K, Hamano T, Kuronuma Y
World Neurosurg 2013 Mar-Apr;79(3-4):594.e1-4. Epub 2012 Apr 3 doi: 10.1016/j.wneu.2012.03.025. PMID: 22484067
Ophthalmoplegic "migraine" or recurrent ophthalmoplegic cranial neuropathy: new cases and a systematic review.
Gelfand AA, Gelfand JM, Prabakhar P, Goadsby PJ
J Child Neurol 2012 Jun;27(6):759-66. Epub 2012 Jan 12 doi: 10.1177/0883073811426502. PMID: 22241707Free PMC Article
Sarcoidosis presenting as "corset-like" myelopathy: a description of six cases and literature review.
Lidar M, Dori A, Levy Y, Lidar Z, Chapman J, Langevitz P
Clin Rev Allergy Immunol 2010 Apr;38(2-3):270-5. doi: 10.1007/s12016-009-8156-8. PMID: 19603148
Granulomatous meningitis.
Loy ST, Tan CW
Singapore Med J 2009 Nov;50(11):e371-3. PMID: 19960146

Prognosis

A rare case of orbital myositis.
Yawar B, Malik Z, Naz F
J Ayub Med Coll Abbottabad 2020 Oct-Dec;32(Suppl 1)(4):S706-S708. PMID: 33754537
Nasopharyngeal B-cell lymphoma with pan-hypopituitarism and oculomotor nerve palsy: a case report and review of the literature.
Zahedi M, Hizomi Arani R, Tohidi M, Haghighi S, Mehrpour M, Hadaegh F
BMC Endocr Disord 2020 Nov 3;20(1):163. doi: 10.1186/s12902-020-00644-y. PMID: 33143716Free PMC Article
Endoscopic third ventriculostomy in patients with myelomeningocele after shunt failure.
Furtado LMF, da Costa Val Filho JA, Holliday JB, da Silva Costa J, de Matos MA, Nascimento VAM, Ramos Cavalcanti T
Childs Nerv Syst 2020 Dec;36(12):3047-3052. Epub 2020 Apr 4 doi: 10.1007/s00381-020-04596-5. PMID: 32248278
Clinical features of IgG4-related dacryoadenitis.
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Iwasaki S, Chiba K, Setoguchi K, Horiguchi S, Ozaki N
Graefes Arch Clin Exp Ophthalmol 2014 Mar;252(3):491-7. Epub 2013 Dec 7 doi: 10.1007/s00417-013-2541-y. PMID: 24318531
Microsurgical findings of Tolosa-Hunt syndrome.
Kodera T, Takeuchi H, Arishima H, Tsunetoshi K, Kitai R, Arai Y, Kikuta K, Hamano T, Kuronuma Y
World Neurosurg 2013 Mar-Apr;79(3-4):594.e1-4. Epub 2012 Apr 3 doi: 10.1016/j.wneu.2012.03.025. PMID: 22484067

Clinical prediction guides

Diabetic Oculomotor Nerve Palsy Displaying Enhancement of the Oculomotor Nerve in the Orbit and Cavernous Sinus on MRI.
Zhao J, Li Y, Chang Q, Wang J, Sun H
Eur Neurol 2021;84(4):246-253. Epub 2021 May 11 doi: 10.1159/000514100. PMID: 33975309
Clinical features of IgG4-related dacryoadenitis.
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Iwasaki S, Chiba K, Setoguchi K, Horiguchi S, Ozaki N
Graefes Arch Clin Exp Ophthalmol 2014 Mar;252(3):491-7. Epub 2013 Dec 7 doi: 10.1007/s00417-013-2541-y. PMID: 24318531
Ophthalmoplegic migraine.
Bek S, Genc G, Demirkaya S, Eroglu E, Odabasi Z
Neurologist 2009 May;15(3):147-9. doi: 10.1097/NRL.0b013e3181870408. PMID: 19430270
Congenital monocular elevation deficiency.
Kim JH, Hwang JM
Ophthalmology 2009 Mar;116(3):580-4. Epub 2009 Jan 22 doi: 10.1016/j.ophtha.2008.10.023. PMID: 19167083
MR of oculomotor nerve palsy.
Blake PY, Mark AS, Kattah J, Kolsky M
AJNR Am J Neuroradiol 1995 Sep;16(8):1665-72. PMID: 7502972Free PMC Article

Recent systematic reviews

Diagnostic controversies in recurrent painful ophthalmoplegic neuropathy: single case report with a systematic review.
Falsaperla R, Presti S, Lo Bianco M, Catanzaro S, Marino S, Ruggieri M
Ital J Pediatr 2022 Jun 3;48(1):82. doi: 10.1186/s13052-022-01274-x. PMID: 35659705Free PMC Article
Ophthalmoplegic "migraine" or recurrent ophthalmoplegic cranial neuropathy: new cases and a systematic review.
Gelfand AA, Gelfand JM, Prabakhar P, Goadsby PJ
J Child Neurol 2012 Jun;27(6):759-66. Epub 2012 Jan 12 doi: 10.1177/0883073811426502. PMID: 22241707Free PMC Article

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