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Abnormal nervous system morphology

MedGen UID:: 868416
•Concept ID:: C4022810
•: Anatomical Abnormality

Synonyms:	Abnormal shape of nervous system; Abnormality of nervous system morphology

HPO:	HP:0012639

Definition

A structural anomaly of the nervous system. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal nervous system morphology

Phenotypic abnormality
- Abnormality of prenatal development or birth
  - Fetal anomaly
    - Congenital Systemic Disorder
      - Abnormality of the nervous system
        Abnormal nervous system morphology
        Abnormal ganglion morphology
        Abnormal cranial ganglion morphology
        Abnormality of ciliary ganglion
        Abnormal peripheral nervous system ganglion morphology
        Abnormal glial cell morphology
        Abnormal astrocyte morphology
        Astrocytoma
        Astrocytosis
        Abnormal microglia morphology
        Abnormal oligodendroglia morphology
        Reduction of oligodendroglia
        Abnormal Schwann cell morphology
        Gliosis
        Basal ganglia gliosis
        Cerebellar gliosis
        Hypothalamic gliosis
        Myelin-dependent gliosis
        Abnormal myelination
        Abnormal CNS myelination
        Cerebral dysmyelination
        CNS demyelination
        CNS hypermyelination
        CNS hypomyelination
        Leukodystrophy
        Abnormal peripheral myelination
        Decreased number of peripheral myelinated nerve fibers
        Onion bulb formation
        Peripheral amyelination
        Peripheral demyelination
        Peripheral dysmyelination
        Peripheral hypermyelination
        Peripheral hypomyelination
        Delayed myelination
        Delayed CNS myelination
        Delayed peripheral myelination
        Demyelinating peripheral neuropathy
        Acute demyelinating polyneuropathy
        Chronic inflammatory demyelinating polyradiculoneuropathy
        Demyelinating sensory neuropathy
        Mixed demyelinating and axonal polyneuropathy
        Abnormal neuron morphology
        Abnormal motor neuron morphology
        Abnormal lower motor neuron morphology
        Abnormal upper motor neuron morphology
        Anterior horn disorder
        Paucity of anterior horn motor neurons
        Abnormal neuron branching
        Decreased dendritic spine number
        Axonal spheroids
        Eosinophilic neuronal inclusion bodies
        Multinucleated neuron
        Neurite dystrophy
        Neuronal intranuclear inclusion bodies
        Abnormal peripheral nervous system morphology
        Abnormal cranial nerve morphology
        Abnorma vestibulocochlear nerve morphology
        Abnormal fifth cranial nerve morphology
        Abnormal sixth cranial nerve morphology
        Abnormal third cranial nerve morphology
        Abnormality of the eleventh cranial nerve
        Cranial nerve compression
        Cranial nerve motor loss
        Hypoplastic trochlear nerve
        Abnormal peripheral nerve morphology by anatomical site
        Abnormal glossopharyngeal nerve morphology
        Abnormal great auricular nerve morphology
        Abnormal lingual nerve morphology
        Abnormality of inferior alveolar nerve
        Sural nerve atrophy
        Decreased size of nerve terminals
        Diffuse axonal swelling
        Enhanced neurotoxicity of vincristine
        Enlarged peripheral nerve
        Hypertrophic nerve changes
        Metachromatic intraneuronal lipid deposits
        Minifascicle formation
        Neuritis
        Brachial plexus neuritis
        Polyneuritis
        Peripheral axon spheroid formation
        Peripheral axonal degeneration
        Axonal degeneration
        Axonal degeneration/regeneration
        Axonal loss
        Axonal regeneration
        Peripheral axonal atrophy
        Peripheral axonal distension
        Peripheral nerve compression
        Peripheral nerve polyglucosan inclusion bodies
        Reduced intraepidermal small nerve fiber density
        Morphological central nervous system abnormality
        Abnormal brain morphology
        Abnormal brainstem morphology
        Abnormal cerebral ventricle morphology
        Abnormal forebrain morphology
        Abnormal hindbrain morphology
        Abnormal midbrain morphology
        Abnormal pituitary gland morphology
        Bilirubin encephalopathy
        Brain atrophy
        Brain parenchymal tuberculoma
        Brain xanthomatosis
        Holoprosencephaly sequence
        Iron accumulation in brain
        Abnormal cerebrospinal fluid morphology
        Abnormal CSF ion concentration
        Abnormal CSF metabolite concentration
        Abnormal CSF protein concentration
        Abnormal CSF/serum albumin ratio
        Abnormality of neutrophil morphology in CSF
        Cerebrospinal fluid erythrocytes
        Cerebrospinal fluid rhinorrhoea
        CSF infectious agent
        CSF pleocytosis
        Extra-axial cerebrospinal fluid accumulation
        Hydrocephalus
        Abnormal meningeal morphology
        Abnormal arachnoid mater morphology
        Abnormal dura mater morphology
        Abnormal pia mater
        Abnormal spinal meningeal morphology
        Basilar meningeal enhancement
        Leptomeningeal enhancement
        Spontaneous cerebrospinal fluid leak
        Subdural hygroma
        Abnormal neural tube morphology
        Neural tube defect
        Abnormal pyramidal tract morphology
        Abnormal corticospinal tract morphology
        Abnormal spinal cord morphology
        Abnormal conus terminalis morphology
        Abnormality of the dorsal column of the spinal cord
        Abnormality of the spinocerebellar tracts
        Cervicomedullary schisis
        Hyperintensity of MRI T2 signal of the spinal cord
        Spinal cord calcifications
        Spinal cord compression
        Spinal cord granuloma
        Spinal cord lesion
        Spinal cord xanthomatosis
        Spinal extradural arachnoid cyst
        Abnormal subarachnoid space morphology
        Distortion of the anterior part of the interhemispheric fissure
        Enlarged interhemispheric fissure
        Interhemispheric cyst
        Subarachnoid hemorrhage
        Widened subarachnoid space
        Abnormality of neuronal migration
        Classical Lissencephalies and Subcortical Band Heterotopias
        Cobblestone lissencephaly
        Gray matter heterotopia
        Lissencephaly
        Periventricular nodular heterotopia
        Alzheimer disease
        Alzheimer disease 2
        Alzheimer disease 3
        Alzheimer disease 4
        Alzheimer disease 6
        Alzheimer disease 7
        Alzheimer disease 8
        Alzheimer disease 9
        Alzheimer disease 10
        Alzheimer disease 11
        Alzheimer disease 12
        Alzheimer disease 13
        Alzheimer disease 14
        Alzheimer disease 16
        Alzheimer disease 17
        Alzheimer disease without neurofibrillary tangles
        Early-onset autosomal dominant Alzheimer disease
        Aplasia/Hypoplasia involving the central nervous system
        Aplasia/Hypoplasia involving the corticospinal tracts
        Aplasia/Hypoplasia of the brainstem
        Aplasia/Hypoplasia of the cerebellum
        Aplasia/Hypoplasia of the cerebrum
        Aplasia/Hypoplasia of the optic tract
        Aplasia/Hypoplasia of the pyramidal tract
        Hypoplasia of olfactory tract
        Atrophy/Degeneration affecting the central nervous system
        Atrophy/Degeneration affecting the brainstem
        Atrophy/Degeneration involving the corticospinal tracts
        Atrophy/Degeneration involving the spinal cord
        Central nervous system degeneration
        Increased cerebral lipofuscin
        Motor neuron atrophy
        Neurodegeneration
        Neuronal loss in central nervous system
        Senile plaques
        Central nervous system axonal spheroid
        Central nervous system cyst
        Arachnoid cyst
        Central Nervous System Colloid Cyst
        Central Nervous System Epidermoid Cyst
        Cerebral cyst
        Choroid plexus cyst
        Colloid cyst
        Endodermal Cyst
        Ependymal cyst
        Intracranial Colloid Cyst
        Intracranial cystic lesion
        Intraspinal Cyst
        Meningeal cyst
        Neurenteric cyst
        Perineural cyst
        Pineal cyst
        Pituitary gland cyst
        Rathke pouch cyst
        Neoplasm of the nervous system
        Cranial nerve neoplasm
        Abducens nerve neoplasm
        Acoustic neuroma
        Facial nerve neoplasm
        Glossopharyngeal nerve neoplasm
        Hypoglossal nerve neoplasm
        Malignant cranial nerve neoplasm
        Oculomotor nerve neoplasm
        Olfactory nerve neoplasm
        Optic nerve neoplasm
        Spinal accessory nerve neoplasm
        Trigeminal nerve neoplasm
        Trochlear nerve neoplasm
        Vagus nerve neoplasm
        Vestibulocochlear nerve neoplasm
        Malignant neoplasm of nervous system
        Malignant neoplasm of the central nervous system
        Metastatic Malignant Neoplasm in the Nervous System
        Peripheral nervous system cancer
        Primitive neuroectodermal tumor
        Neoplasm of the central nervous system
        Adult Central Nervous System Neoplasm
        Benign neoplasm of the central nervous system
        Central nervous system hematopoietic neoplasm
        Childhood Central Nervous System Neoplasm
        Intracranial Neoplasm
        Intraspinal Neoplasm
        Neoplasm of brain
        Neuronal/glioneuronal neoplasm of the central nervous system
        Primary Central Nervous System Neoplasm
        Spinal cord tumor
        Tumor of meninges
        Neoplasm of the peripheral nervous system
        Autonomic nervous system neoplasm
        Benign peripheral nerve granular cell tumor
        Childhood mediastinal neurogenic neoplasm
        Cutaneous Neural Neoplasm
        Hemangioma of peripheral nerve
        Intraneural perineurioma
        Lipomatosis of Nerve
        Nerve plexus neoplasm
        Nerve sheath neoplasm
        Neurofibroma
        Neuroma
        Neurothekeoma
        Peripheral nerve schwannoma
        Peripheral neuroepithelioma
        Schwannoma
        Nerve root neoplasm
        Cauda equina neoplasm
        Nervous system benign neoplasm
        Benign Central Nervous System Mesenchymal, Non-Meningothelial Neoplasm
        Benign granular cell tumor
        Benign Intracranial Neoplasm
        Benign neoplasm of spinal cord
        Central nervous system mature teratoma
        Childhood Benign Central Nervous System Neoplasm
        Ganglioneuroma
        Hybrid Nerve Sheath Tumor
        Non-Metastatic Paraganglioma
        Perineurioma
        Solitary Circumscribed Neuroma
        Neuroepithelial, Perineurial, and Schwann Cell Neoplasm
        Neuroepithelial neoplasm
        Neurolymphomatosis
        Paraneoplastic neurologic syndrome
        Anti-NMDA receptor encephalitis
        Cancer-associated retinopathy
        Eaton-Lambert syndrome
        Limbic encephalitis
        Myasthenia gravis
        Opsoclonus-myoclonus syndrome
        Paraneoplastic cerebellar degeneration
        Paraneoplastic isolated brainstem encephalitis
        Paraneoplastic polyneuropathy
        Paraneoplastic sensory ganglionopathy
        Transverse myelitis

Professional guidelines

PubMed

Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup.

Jack CR Jr, Andrews JS, Beach TG, Buracchio T, Dunn B, Graf A, Hansson O, Ho C, Jagust W, McDade E, Molinuevo JL, Okonkwo OC, Pani L, Rafii MS, Scheltens P, Siemers E, Snyder HM, Sperling R, Teunissen CE, Carrillo MC
Alzheimers Dement 2024 Aug;20(8):5143-5169. Epub 2024 Jun 27 doi: 10.1002/alz.13859. PMID: 38934362 Free PMC Article

Prenatal diagnosis of brainstem anomalies.

Haratz KK, Lerman-Sagie T
Eur J Paediatr Neurol 2018 Nov;22(6):1016-1026. Epub 2018 Jul 6 doi: 10.1016/j.ejpn.2018.06.011. PMID: 30448280

Craniosynostosis - Recognition, clinical characteristics, and treatment.

Kajdic N, Spazzapan P, Velnar T
Bosn J Basic Med Sci 2018 May 20;18(2):110-116. doi: 10.17305/bjbms.2017.2083. PMID: 28623672 Free PMC Article

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