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Elevated circulating complement component concentration

MedGen UID:
1053088
•Concept ID:
CN377306
•
Finding
HPO: HP:6000474

Definition

Concentration of a complement component in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating complement component concentration

Recent clinical studies

Etiology

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Systems immunology reveals a linked IgG3-C4 response in patients with acute rheumatic fever.
Chung AW, Ho TK, Hanson-Manful P, Tritscheller S, Raynes JM, Whitcombe AL, Tay ML, McGregor R, Lorenz N, Oliver JR, Gurney JK, Print CG, Wilson NJ, Martin WJ, Williamson DA, Baker MG, Moreland NJ
Immunol Cell Biol 2020 Jan;98(1):12-21. Epub 2019 Nov 18 doi: 10.1111/imcb.12298. PMID: 31742781
Complement C3 and cleavage products in cardiometabolic risk.
Onat A, Can G, Rezvani R, Cianflone K
Clin Chim Acta 2011 Jun 11;412(13-14):1171-9. Epub 2011 Mar 15 doi: 10.1016/j.cca.2011.03.005. PMID: 21419112
Activation of the complement system in normal pregnancy and preeclampsia.
Derzsy Z, Prohászka Z, Rigó J Jr, Füst G, Molvarec A
Mol Immunol 2010 Apr;47(7-8):1500-6. Epub 2010 Feb 23 doi: 10.1016/j.molimm.2010.01.021. PMID: 20181396
Elevated fibrin(ogen) degradation products in the adult respiratory distress syndrome.
Haynes JB, Hyers TM, Giclas PC, Franks JJ, Petty TL
Am Rev Respir Dis 1980 Dec;122(6):841-7. doi: 10.1164/arrd.1980.122.6.841. PMID: 6450559

Diagnosis

Complement C1s deficiency in a male Caucasian patient with systemic lupus erythematosus: a case report.
Kleer JS, Skattum L, Dubler D, Fischer I, Zgraggen A, Mundwiler E, Kim MJ, Trendelenburg M
Front Immunol 2023;14:1257525. Epub 2024 Feb 26 doi: 10.3389/fimmu.2023.1257525. PMID: 38469558Free PMC Article
Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Maternal C3 complement and C-reactive protein and pregnancy and fetal outcomes: A secondary analysis of the PEARS RCT-An mHealth-supported, lifestyle intervention among pregnant women with overweight and obesity.
Kennelly MA, Killeen SL, Phillips CM, Alberdi G, Lindsay KL, Mehegan J, Cronin M, McAuliffe FM
Cytokine 2022 Jan;149:155748. Epub 2021 Oct 23 doi: 10.1016/j.cyto.2021.155748. PMID: 34700074Free PMC Article
Systems immunology reveals a linked IgG3-C4 response in patients with acute rheumatic fever.
Chung AW, Ho TK, Hanson-Manful P, Tritscheller S, Raynes JM, Whitcombe AL, Tay ML, McGregor R, Lorenz N, Oliver JR, Gurney JK, Print CG, Wilson NJ, Martin WJ, Williamson DA, Baker MG, Moreland NJ
Immunol Cell Biol 2020 Jan;98(1):12-21. Epub 2019 Nov 18 doi: 10.1111/imcb.12298. PMID: 31742781
Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus.
Asano T, Ito H, Kariya Y, Hoshi K, Yoshihara A, Ugawa Y, Sekine H, Hirohata S, Yamaguchi Y, Sato S, Kobayashi H, Migita K, Ohira H, Hashimoto Y, Watanabe H
PLoS One 2017;12(10):e0186414. Epub 2017 Oct 16 doi: 10.1371/journal.pone.0186414. PMID: 29036223Free PMC Article

Therapy

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Maternal C3 complement and C-reactive protein and pregnancy and fetal outcomes: A secondary analysis of the PEARS RCT-An mHealth-supported, lifestyle intervention among pregnant women with overweight and obesity.
Kennelly MA, Killeen SL, Phillips CM, Alberdi G, Lindsay KL, Mehegan J, Cronin M, McAuliffe FM
Cytokine 2022 Jan;149:155748. Epub 2021 Oct 23 doi: 10.1016/j.cyto.2021.155748. PMID: 34700074Free PMC Article
Systems immunology reveals a linked IgG3-C4 response in patients with acute rheumatic fever.
Chung AW, Ho TK, Hanson-Manful P, Tritscheller S, Raynes JM, Whitcombe AL, Tay ML, McGregor R, Lorenz N, Oliver JR, Gurney JK, Print CG, Wilson NJ, Martin WJ, Williamson DA, Baker MG, Moreland NJ
Immunol Cell Biol 2020 Jan;98(1):12-21. Epub 2019 Nov 18 doi: 10.1111/imcb.12298. PMID: 31742781
Molecular basis of reduced LAIR1 expression in childhood severe malarial anaemia: Implications for leukocyte inhibitory signalling.
Achieng AO, Guyah B, Cheng Q, Ong'echa JM, Ouma C, Lambert CG, Perkins DJ
EBioMedicine 2019 Jul;45:278-289. Epub 2019 Jun 27 doi: 10.1016/j.ebiom.2019.06.040. PMID: 31257148Free PMC Article
Circulating microparticles remain associated with complement activation despite intensive anti-inflammatory therapy in early rheumatoid arthritis.
van Eijk IC, Tushuizen ME, Sturk A, Dijkmans BA, Boers M, Voskuyl AE, Diamant M, Wolbink GJ, Nieuwland R, Nurmohamed MT
Ann Rheum Dis 2010 Jul;69(7):1378-82. Epub 2009 Nov 16 doi: 10.1136/ard.2009.118372. PMID: 19919943

Prognosis

Maternal C3 complement and C-reactive protein and pregnancy and fetal outcomes: A secondary analysis of the PEARS RCT-An mHealth-supported, lifestyle intervention among pregnant women with overweight and obesity.
Kennelly MA, Killeen SL, Phillips CM, Alberdi G, Lindsay KL, Mehegan J, Cronin M, McAuliffe FM
Cytokine 2022 Jan;149:155748. Epub 2021 Oct 23 doi: 10.1016/j.cyto.2021.155748. PMID: 34700074Free PMC Article
Complement C3 and cleavage products in cardiometabolic risk.
Onat A, Can G, Rezvani R, Cianflone K
Clin Chim Acta 2011 Jun 11;412(13-14):1171-9. Epub 2011 Mar 15 doi: 10.1016/j.cca.2011.03.005. PMID: 21419112
Circulating microparticles remain associated with complement activation despite intensive anti-inflammatory therapy in early rheumatoid arthritis.
van Eijk IC, Tushuizen ME, Sturk A, Dijkmans BA, Boers M, Voskuyl AE, Diamant M, Wolbink GJ, Nieuwland R, Nurmohamed MT
Ann Rheum Dis 2010 Jul;69(7):1378-82. Epub 2009 Nov 16 doi: 10.1136/ard.2009.118372. PMID: 19919943
Reference distributions for complement proteins C3 and C4: a practical, simple and clinically relevant approach in a large cohort.
Ritchie RF, Palomaki GE, Neveux LM, Navolotskaia O, Ledue TB, Craig WY
J Clin Lab Anal 2004;18(1):1-8. doi: 10.1002/jcla.10100. PMID: 14730550Free PMC Article
Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome.
Stöve S, Welte T, Wagner TO, Kola A, Klos A, Bautsch W, Köhl J
Clin Diagn Lab Immunol 1996 Mar;3(2):175-83. doi: 10.1128/cdli.3.2.175-183.1996. PMID: 8991632Free PMC Article

Clinical prediction guides

Maternal C3 complement and C-reactive protein and pregnancy and fetal outcomes: A secondary analysis of the PEARS RCT-An mHealth-supported, lifestyle intervention among pregnant women with overweight and obesity.
Kennelly MA, Killeen SL, Phillips CM, Alberdi G, Lindsay KL, Mehegan J, Cronin M, McAuliffe FM
Cytokine 2022 Jan;149:155748. Epub 2021 Oct 23 doi: 10.1016/j.cyto.2021.155748. PMID: 34700074Free PMC Article
Systems immunology reveals a linked IgG3-C4 response in patients with acute rheumatic fever.
Chung AW, Ho TK, Hanson-Manful P, Tritscheller S, Raynes JM, Whitcombe AL, Tay ML, McGregor R, Lorenz N, Oliver JR, Gurney JK, Print CG, Wilson NJ, Martin WJ, Williamson DA, Baker MG, Moreland NJ
Immunol Cell Biol 2020 Jan;98(1):12-21. Epub 2019 Nov 18 doi: 10.1111/imcb.12298. PMID: 31742781
Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus.
Asano T, Ito H, Kariya Y, Hoshi K, Yoshihara A, Ugawa Y, Sekine H, Hirohata S, Yamaguchi Y, Sato S, Kobayashi H, Migita K, Ohira H, Hashimoto Y, Watanabe H
PLoS One 2017;12(10):e0186414. Epub 2017 Oct 16 doi: 10.1371/journal.pone.0186414. PMID: 29036223Free PMC Article
Complement C3 and cleavage products in cardiometabolic risk.
Onat A, Can G, Rezvani R, Cianflone K
Clin Chim Acta 2011 Jun 11;412(13-14):1171-9. Epub 2011 Mar 15 doi: 10.1016/j.cca.2011.03.005. PMID: 21419112
Reference distributions for complement proteins C3 and C4: a practical, simple and clinically relevant approach in a large cohort.
Ritchie RF, Palomaki GE, Neveux LM, Navolotskaia O, Ledue TB, Craig WY
J Clin Lab Anal 2004;18(1):1-8. doi: 10.1002/jcla.10100. PMID: 14730550Free PMC Article

Recent systematic reviews

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118

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