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Elevated circulating complement C3 concentration

MedGen UID:
1053217
•Concept ID:
CN377275
•
Finding
HPO: HP:0430146

Definition

Concentration of the complement component C3 in the blood circulation above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating complement C3 concentration

Recent clinical studies

Etiology

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Complement C3 and incident hospitalization due to chronic kidney disease: a population-based cohort study.
Bao X, Borné Y, Muhammad IF, Schulz CA, Persson M, Orho-Melander M, Niu K, Christensson A, Engström G
BMC Nephrol 2019 Feb 21;20(1):61. doi: 10.1186/s12882-019-1248-7. PMID: 30791918Free PMC Article
Complement C3 and cleavage products in cardiometabolic risk.
Onat A, Can G, Rezvani R, Cianflone K
Clin Chim Acta 2011 Jun 11;412(13-14):1171-9. Epub 2011 Mar 15 doi: 10.1016/j.cca.2011.03.005. PMID: 21419112
Long-term hyposensitization and adverse immunologic responses. A laboratory evaluation.
Negrini AC, Troise C, Voltolini S, Siccardi M, Grassia L
Ann Allergy 1985 Jun;54(6):534-7. PMID: 3893231
Elevated fibrin(ogen) degradation products in the adult respiratory distress syndrome.
Haynes JB, Hyers TM, Giclas PC, Franks JJ, Petty TL
Am Rev Respir Dis 1980 Dec;122(6):841-7. doi: 10.1164/arrd.1980.122.6.841. PMID: 6450559

Diagnosis

Complement C1s deficiency in a male Caucasian patient with systemic lupus erythematosus: a case report.
Kleer JS, Skattum L, Dubler D, Fischer I, Zgraggen A, Mundwiler E, Kim MJ, Trendelenburg M
Front Immunol 2023;14:1257525. Epub 2024 Feb 26 doi: 10.3389/fimmu.2023.1257525. PMID: 38469558Free PMC Article
Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Maternal C3 complement and C-reactive protein and pregnancy and fetal outcomes: A secondary analysis of the PEARS RCT-An mHealth-supported, lifestyle intervention among pregnant women with overweight and obesity.
Kennelly MA, Killeen SL, Phillips CM, Alberdi G, Lindsay KL, Mehegan J, Cronin M, McAuliffe FM
Cytokine 2022 Jan;149:155748. Epub 2021 Oct 23 doi: 10.1016/j.cyto.2021.155748. PMID: 34700074Free PMC Article
Complement C3 and incident hospitalization due to chronic kidney disease: a population-based cohort study.
Bao X, Borné Y, Muhammad IF, Schulz CA, Persson M, Orho-Melander M, Niu K, Christensson A, Engström G
BMC Nephrol 2019 Feb 21;20(1):61. doi: 10.1186/s12882-019-1248-7. PMID: 30791918Free PMC Article
IgE-containing circulating immune complexes in Churg-Strauss vasculitis.
Manger BJ, Krapf FE, Gramatzki M, Nüsslein HG, Burmester GR, Krauledat PB, Kalden JR
Scand J Immunol 1985 Apr;21(4):369-73. doi: 10.1111/j.1365-3083.1985.tb01443.x. PMID: 3890149

Therapy

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Maternal C3 complement and C-reactive protein and pregnancy and fetal outcomes: A secondary analysis of the PEARS RCT-An mHealth-supported, lifestyle intervention among pregnant women with overweight and obesity.
Kennelly MA, Killeen SL, Phillips CM, Alberdi G, Lindsay KL, Mehegan J, Cronin M, McAuliffe FM
Cytokine 2022 Jan;149:155748. Epub 2021 Oct 23 doi: 10.1016/j.cyto.2021.155748. PMID: 34700074Free PMC Article
Hemodialysis leads to plasma depletion of lectin complement pathway initiator molecule ficolin-2.
Nielsen TL, Pilely K, Lund KP, Warming PE, Plesner LL, Iversen KK, Garred P
Hemodial Int 2021 Oct;25(4):479-488. Epub 2021 Jun 16 doi: 10.1111/hdi.12948. PMID: 34132045
Long-term hyposensitization and adverse immunologic responses. A laboratory evaluation.
Negrini AC, Troise C, Voltolini S, Siccardi M, Grassia L
Ann Allergy 1985 Jun;54(6):534-7. PMID: 3893231
IgE-containing circulating immune complexes in Churg-Strauss vasculitis.
Manger BJ, Krapf FE, Gramatzki M, Nüsslein HG, Burmester GR, Krauledat PB, Kalden JR
Scand J Immunol 1985 Apr;21(4):369-73. doi: 10.1111/j.1365-3083.1985.tb01443.x. PMID: 3890149

Prognosis

Maternal C3 complement and C-reactive protein and pregnancy and fetal outcomes: A secondary analysis of the PEARS RCT-An mHealth-supported, lifestyle intervention among pregnant women with overweight and obesity.
Kennelly MA, Killeen SL, Phillips CM, Alberdi G, Lindsay KL, Mehegan J, Cronin M, McAuliffe FM
Cytokine 2022 Jan;149:155748. Epub 2021 Oct 23 doi: 10.1016/j.cyto.2021.155748. PMID: 34700074Free PMC Article
Complement C3 and incident hospitalization due to chronic kidney disease: a population-based cohort study.
Bao X, Borné Y, Muhammad IF, Schulz CA, Persson M, Orho-Melander M, Niu K, Christensson A, Engström G
BMC Nephrol 2019 Feb 21;20(1):61. doi: 10.1186/s12882-019-1248-7. PMID: 30791918Free PMC Article
Complement activation, inflammation and relative ADAMTS13 deficiency in secondary thrombotic microangiopathies.
Farkas P, Csuka D, Mikes B, Sinkovits G, Réti M, Németh E, Rácz K, Madách K, Gergely M, Demeter J, Prohászka Z
Immunobiology 2017 Feb;222(2):119-127. Epub 2016 Oct 18 doi: 10.1016/j.imbio.2016.10.014. PMID: 27771173
Complement C3 and cleavage products in cardiometabolic risk.
Onat A, Can G, Rezvani R, Cianflone K
Clin Chim Acta 2011 Jun 11;412(13-14):1171-9. Epub 2011 Mar 15 doi: 10.1016/j.cca.2011.03.005. PMID: 21419112
Reference distributions for complement proteins C3 and C4: a practical, simple and clinically relevant approach in a large cohort.
Ritchie RF, Palomaki GE, Neveux LM, Navolotskaia O, Ledue TB, Craig WY
J Clin Lab Anal 2004;18(1):1-8. doi: 10.1002/jcla.10100. PMID: 14730550Free PMC Article

Clinical prediction guides

Maternal C3 complement and C-reactive protein and pregnancy and fetal outcomes: A secondary analysis of the PEARS RCT-An mHealth-supported, lifestyle intervention among pregnant women with overweight and obesity.
Kennelly MA, Killeen SL, Phillips CM, Alberdi G, Lindsay KL, Mehegan J, Cronin M, McAuliffe FM
Cytokine 2022 Jan;149:155748. Epub 2021 Oct 23 doi: 10.1016/j.cyto.2021.155748. PMID: 34700074Free PMC Article
Complement C3 and incident hospitalization due to chronic kidney disease: a population-based cohort study.
Bao X, Borné Y, Muhammad IF, Schulz CA, Persson M, Orho-Melander M, Niu K, Christensson A, Engström G
BMC Nephrol 2019 Feb 21;20(1):61. doi: 10.1186/s12882-019-1248-7. PMID: 30791918Free PMC Article
Complement C3 and cleavage products in cardiometabolic risk.
Onat A, Can G, Rezvani R, Cianflone K
Clin Chim Acta 2011 Jun 11;412(13-14):1171-9. Epub 2011 Mar 15 doi: 10.1016/j.cca.2011.03.005. PMID: 21419112
Reference distributions for complement proteins C3 and C4: a practical, simple and clinically relevant approach in a large cohort.
Ritchie RF, Palomaki GE, Neveux LM, Navolotskaia O, Ledue TB, Craig WY
J Clin Lab Anal 2004;18(1):1-8. doi: 10.1002/jcla.10100. PMID: 14730550Free PMC Article
Soluble immune complexes, acute phase proteins and E-rosette inhibitory substance in sera of malnourished children.
Salimonu LS
Ann Trop Paediatr 1985 Sep;5(3):137-41. doi: 10.1080/02724936.1985.11748379. PMID: 2415051

Recent systematic reviews

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Apical Periodontitis Is Associated with Elevated Concentrations of Inflammatory Mediators in Peripheral Blood: A Systematic Review and Meta-analysis.
Georgiou AC, Crielaard W, Armenis I, de Vries R, van der Waal SV
J Endod 2019 Nov;45(11):1279-1295.e3. Epub 2019 Sep 19 doi: 10.1016/j.joen.2019.07.017. PMID: 31542282

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