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Elevated urinary histamine level

MedGen UID:
1053554
•Concept ID:
CN377363
•
Finding
HPO: HP:6000532

Definition

The amount of histamine in the urine, normalized for urine concentration, is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated urinary histamine level

Professional guidelines

PubMed

Differential expression of histamine receptors in the bladder wall tissues of patients with bladder pain syndrome/interstitial cystitis - significance in the responsiveness to antihistamine treatment and disease symptoms.
Shan H, Zhang EW, Zhang P, Zhang XD, Zhang N, Du P, Yang Y
BMC Urol 2019 Nov 12;19(1):115. doi: 10.1186/s12894-019-0548-3. PMID: 31718622Free PMC Article
Effects of eight-week treatment with oral ranitidine on plasma level changes of gastrin, histamine and serotonin in duodenal ulcer patients.
Cho CH, Lai KH, Wang JY, Lee SD, Tsai YT
Pharmacol Res Commun 1985 Jun;17(6):525-33. doi: 10.1016/0031-6989(85)90125-0. PMID: 2410935
Cimetidine treatment of azotemic secondary hyperparathyroidism.
Robinson MF, Johnson WJ, Heath H 3rd
J Clin Endocrinol Metab 1982 Jun;54(6):1206-9. doi: 10.1210/jcem-54-6-1206. PMID: 6281294

Recent clinical studies

Etiology

Differential mast cell mediators in systemic mastocytosis and hereditary α-tryptasemia.
Giannetti MP, Godwin G, Weller E, Butterfield JH, Castells M
J Allergy Clin Immunol 2022 Nov;150(5):1225-1227. Epub 2022 May 9 doi: 10.1016/j.jaci.2022.04.025. PMID: 35550148
Increased urinary l-histidine in patients with asthma-COPD overlap: a pilot study.
Oh JY, Lee YS, Min KH, Hur GY, Lee SY, Kang KH, Rhee CK, Park SJ, Khan A, Na J, Park YH, Shim JJ
Int J Chron Obstruct Pulmon Dis 2018;13:1809-1818. Epub 2018 Jun 5 doi: 10.2147/COPD.S163189. PMID: 29892192Free PMC Article
Anaphylaxis.
LoVerde D, Iweala OI, Eginli A, Krishnaswamy G
Chest 2018 Feb;153(2):528-543. Epub 2017 Aug 8 doi: 10.1016/j.chest.2017.07.033. PMID: 28800865Free PMC Article
Assessment of in vivo mast cell reactivity in patients with systemic mastocytosis.
Gülen T, Möller Westerberg C, Lyberg K, Ekoff M, Kolmert J, Bood J, Öhd J, James A, Dahlén SE, Nilsson G, Dahlén B
Clin Exp Allergy 2017 Jul;47(7):909-917. Epub 2017 Apr 4 doi: 10.1111/cea.12914. PMID: 28258965
Excretion of urinary histamine and N-tele methylhistamine in patients with gastrointestinal food allergy compared to non-allergic controls during an unrestricted diet and a hypoallergenic diet.
Raithel M, Hagel A, Albrecht H, Zopf Y, Naegel A, Baenkler HW, Buchwald F, Schultis HW, Kressel J, Hahn EG, Konturek P
BMC Gastroenterol 2015 Apr 1;15:41. doi: 10.1186/s12876-015-0268-4. PMID: 25888445Free PMC Article

Diagnosis

Renal histaminergic system and acute effects of histamine receptor 2 blockade on renal damage in the Dahl salt-sensitive rat.
Spires DR, Schibalski RS, Domondon M, Clarke C, Perez S, Anwar F, Burns E, Saeed MI, Walton SD, Zamaro AS, Amoah T, Arkhipov SN, Christopher CJ, Campagna SR, Mattson DL, Pavlov TS, Ilatovskaya DV
Am J Physiol Renal Physiol 2023 Jul 1;325(1):F105-F120. Epub 2023 May 25 doi: 10.1152/ajprenal.00269.2022. PMID: 37227223Free PMC Article
Differential mast cell mediators in systemic mastocytosis and hereditary α-tryptasemia.
Giannetti MP, Godwin G, Weller E, Butterfield JH, Castells M
J Allergy Clin Immunol 2022 Nov;150(5):1225-1227. Epub 2022 May 9 doi: 10.1016/j.jaci.2022.04.025. PMID: 35550148
Nontryptase Urinary and Hematologic Biomarkers of Mast Cell Expansion and Mast Cell Activation: Status 2022.
Butterfield JH
J Allergy Clin Immunol Pract 2022 Aug;10(8):1974-1984. Epub 2022 Mar 26 doi: 10.1016/j.jaip.2022.03.008. PMID: 35346887
Mast Cell Mediators of Significance in Clinical Practice in Mastocytosis.
Butterfield JH, Ravi A, Pongdee T
Immunol Allergy Clin North Am 2018 Aug;38(3):397-410. Epub 2018 Jun 9 doi: 10.1016/j.iac.2018.04.011. PMID: 30007459
Anaphylaxis.
LoVerde D, Iweala OI, Eginli A, Krishnaswamy G
Chest 2018 Feb;153(2):528-543. Epub 2017 Aug 8 doi: 10.1016/j.chest.2017.07.033. PMID: 28800865Free PMC Article

Therapy

Nontryptase Urinary and Hematologic Biomarkers of Mast Cell Expansion and Mast Cell Activation: Status 2022.
Butterfield JH
J Allergy Clin Immunol Pract 2022 Aug;10(8):1974-1984. Epub 2022 Mar 26 doi: 10.1016/j.jaip.2022.03.008. PMID: 35346887
Mast cell function in prostate inflammation, fibrosis, and smooth muscle cell dysfunction.
Pattabiraman G, Bell-Cohn AJ, Murphy SF, Mazur DJ, Schaeffer AJ, Thumbikat P
Am J Physiol Renal Physiol 2021 Oct 1;321(4):F466-F479. Epub 2021 Aug 23 doi: 10.1152/ajprenal.00116.2021. PMID: 34423679Free PMC Article
Anaphylaxis.
LoVerde D, Iweala OI, Eginli A, Krishnaswamy G
Chest 2018 Feb;153(2):528-543. Epub 2017 Aug 8 doi: 10.1016/j.chest.2017.07.033. PMID: 28800865Free PMC Article
Excretion of urinary histamine and N-tele methylhistamine in patients with gastrointestinal food allergy compared to non-allergic controls during an unrestricted diet and a hypoallergenic diet.
Raithel M, Hagel A, Albrecht H, Zopf Y, Naegel A, Baenkler HW, Buchwald F, Schultis HW, Kressel J, Hahn EG, Konturek P
BMC Gastroenterol 2015 Apr 1;15:41. doi: 10.1186/s12876-015-0268-4. PMID: 25888445Free PMC Article
Osteoporosis as the sole manifestation of systemic mastocytosis in a young man.
Abramowitz JD, Weinerman SA
Endocr Pract 2012 Nov-Dec;18(6):e158-61. doi: 10.4158/EP12062.CR. PMID: 23246689

Prognosis

Physiologically-Based Pharmacokinetic Modelling of Creatinine-Drug Interactions in the Chronic Kidney Disease Population.
Takita H, Scotcher D, Chinnadurai R, Kalra PA, Galetin A
CPT Pharmacometrics Syst Pharmacol 2020 Dec;9(12):695-706. Epub 2020 Nov 23 doi: 10.1002/psp4.12566. PMID: 33049120Free PMC Article
Histidine metabolism after Bretschneider cardioplegia in cardiac surgical patients.
Teloh JK, Ansorge L, Petersen M, Demircioglu E, Waack IN, Brauckmann S, Jakob H, Dohle DS
Physiol Res 2018 May 4;67(2):209-216. Epub 2018 Jan 5 doi: 10.33549/physiolres.933691. PMID: 29303608
Mast cell activation syndrome: improved identification by combined determinations of serum tryptase and 24-hour urine 11β-prostaglandin2α.
Ravi A, Butterfield J, Weiler CR
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):775-8. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.06.011. PMID: 25439370
Biochemical markers in the follow-up of medullary thyroid cancer.
de Groot JW, Kema IP, Breukelman H, van der Veer E, Wiggers T, Plukker JT, Wolffenbuttel BH, Links TP
Thyroid 2006 Nov;16(11):1163-70. doi: 10.1089/thy.2006.16.1163. PMID: 17123344
Eosinophil degranulation during pregnancy and after delivery by cesarean section.
Matsumoto K, Ogasawara T, Kato A, Homma T, Iida M, Akasawa A, Wakiguchi H, Saito H
Int Arch Allergy Immunol 2003 Jun;131 Suppl 1:34-9. doi: 10.1159/000070479. PMID: 12771547

Clinical prediction guides

Renal histaminergic system and acute effects of histamine receptor 2 blockade on renal damage in the Dahl salt-sensitive rat.
Spires DR, Schibalski RS, Domondon M, Clarke C, Perez S, Anwar F, Burns E, Saeed MI, Walton SD, Zamaro AS, Amoah T, Arkhipov SN, Christopher CJ, Campagna SR, Mattson DL, Pavlov TS, Ilatovskaya DV
Am J Physiol Renal Physiol 2023 Jul 1;325(1):F105-F120. Epub 2023 May 25 doi: 10.1152/ajprenal.00269.2022. PMID: 37227223Free PMC Article
Mast cell function in prostate inflammation, fibrosis, and smooth muscle cell dysfunction.
Pattabiraman G, Bell-Cohn AJ, Murphy SF, Mazur DJ, Schaeffer AJ, Thumbikat P
Am J Physiol Renal Physiol 2021 Oct 1;321(4):F466-F479. Epub 2021 Aug 23 doi: 10.1152/ajprenal.00116.2021. PMID: 34423679Free PMC Article
Excretion of urinary histamine and N-tele methylhistamine in patients with gastrointestinal food allergy compared to non-allergic controls during an unrestricted diet and a hypoallergenic diet.
Raithel M, Hagel A, Albrecht H, Zopf Y, Naegel A, Baenkler HW, Buchwald F, Schultis HW, Kressel J, Hahn EG, Konturek P
BMC Gastroenterol 2015 Apr 1;15:41. doi: 10.1186/s12876-015-0268-4. PMID: 25888445Free PMC Article
Osteoporosis as the sole manifestation of systemic mastocytosis in a young man.
Abramowitz JD, Weinerman SA
Endocr Pract 2012 Nov-Dec;18(6):e158-61. doi: 10.4158/EP12062.CR. PMID: 23246689
Eosinophil degranulation during pregnancy and after delivery by cesarean section.
Matsumoto K, Ogasawara T, Kato A, Homma T, Iida M, Akasawa A, Wakiguchi H, Saito H
Int Arch Allergy Immunol 2003 Jun;131 Suppl 1:34-9. doi: 10.1159/000070479. PMID: 12771547

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