U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Elevated circulating tumor necrosis factor alpha concentration

MedGen UID:
1053640
•Concept ID:
CN376752
•
Finding
HPO: HP:6000239

Definition

The concentration of tumor necrosis factor alpha in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating tumor necrosis factor alpha concentration

Professional guidelines

PubMed

Aging, traumatic injury, and estrogen treatment.
Kovacs EJ
Exp Gerontol 2005 Jul;40(7):549-55. doi: 10.1016/j.exger.2005.04.009. PMID: 15975753
Tumor necrosis factor-alpha serum activity during treatment of acute decompensation of cachectic and non-cachectic patients with advanced congestive heart failure.
Parissis JT, Venetsanou KF, Mentzikof DG, Ziras NG, Kefalas CG, Karas SM
Scand Cardiovasc J 1999;33(6):344-50. doi: 10.1080/14017439950141407. PMID: 10622546
Polyclonal anti-tumor necrosis factor-alpha Fab used as an ancillary treatment for severe malaria.
Looareesuwan S, Sjostrom L, Krudsood S, Wilairatana P, Porter RS, Hills F, Warrell DA
Am J Trop Med Hyg 1999 Jul;61(1):26-33. doi: 10.4269/ajtmh.1999.61.26. PMID: 10432050

Recent clinical studies

Etiology

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Leptin in autoimmune diseases.
Procaccini C, Pucino V, Mantzoros CS, Matarese G
Metabolism 2015 Jan;64(1):92-104. Epub 2014 Oct 23 doi: 10.1016/j.metabol.2014.10.014. PMID: 25467840
The tumour necrosis factor-related apoptosis-inducing ligand-osteoprotegerin system in limited systemic sclerosis: a new disease marker?
Castellino G, Corallini F, Bortoluzzi A, La Corte R, Lo Monaco A, Secchiero P, Zauli G, Trotta F
Rheumatology (Oxford) 2010 Jun;49(6):1173-6. Epub 2010 Mar 18 doi: 10.1093/rheumatology/keq064. PMID: 20299382
Hormone-cytokine response. Pneumoperitoneum vs abdominal wall-lifting in laparoscopic cholecystectomy.
Yoshida T, Kobayashi E, Suminaga Y, Yamauchi H, Kai T, Toyama N, Kiyozaki H, Fujimura A, Miyata M
Surg Endosc 1997 Sep;11(9):907-10. doi: 10.1007/s004649900484. PMID: 9294270
Pattern of soluble TNF receptors I and II in sepsis.
Schröder J, Stüber F, Gallati H, Schade FU, Kremer B
Infection 1995 May-Jun;23(3):143-8. doi: 10.1007/BF01793854. PMID: 7499002

Diagnosis

Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis.
Tylutka A, Walas Ł, Zembron-Lacny A
Front Immunol 2024;15:1330386. Epub 2024 Mar 1 doi: 10.3389/fimmu.2024.1330386. PMID: 38495887Free PMC Article
Serum IL-17 and TNFα as prognostic biomarkers in systemic sclerosis patients: a prospective study.
Kosałka-Węgiel J, Lichołai S, Pacholczak-Madej R, Dziedzina S, Milewski M, Kuszmiersz P, Korona A, Gąsior J, Matyja-Bednarczyk A, Kwiatkowska H, Zaręba L, Siwiec-Koźlik A, Koźlik-Siwiec P, Wach A, Pociej-Marciak W, Sanak M, Musiał J, Bazan-Socha S, Korkosz M
Rheumatol Int 2024 Jan;44(1):119-128. Epub 2023 Dec 5 doi: 10.1007/s00296-023-05499-9. PMID: 38051374Free PMC Article
Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Cytokine profile in multiple myeloma.
Jasrotia S, Gupta R, Sharma A, Halder A, Kumar L
Cytokine 2020 Dec;136:155271. Epub 2020 Sep 8 doi: 10.1016/j.cyto.2020.155271. PMID: 32916474
Hormone-cytokine response. Pneumoperitoneum vs abdominal wall-lifting in laparoscopic cholecystectomy.
Yoshida T, Kobayashi E, Suminaga Y, Yamauchi H, Kai T, Toyama N, Kiyozaki H, Fujimura A, Miyata M
Surg Endosc 1997 Sep;11(9):907-10. doi: 10.1007/s004649900484. PMID: 9294270

Therapy

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Smoking cessation reduces systemic inflammation and circulating endothelin-1.
Derella CC, Tingen MS, Blanks A, Sojourner SJ, Tucker MA, Thomas J, Harris RA
Sci Rep 2021 Dec 16;11(1):24122. doi: 10.1038/s41598-021-03476-5. PMID: 34916543Free PMC Article
Interleukin 38 Protects Against Lethal Sepsis.
Xu F, Lin S, Yan X, Wang C, Tu H, Yin Y, Cao J
J Infect Dis 2018 Aug 24;218(7):1175-1184. doi: 10.1093/infdis/jiy289. PMID: 29762676
Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis.
Escobar-Morreale HF, Luque-Ramírez M, González F
Fertil Steril 2011 Mar 1;95(3):1048-58.e1-2. Epub 2010 Dec 17 doi: 10.1016/j.fertnstert.2010.11.036. PMID: 21168133Free PMC Article
Hormone-cytokine response. Pneumoperitoneum vs abdominal wall-lifting in laparoscopic cholecystectomy.
Yoshida T, Kobayashi E, Suminaga Y, Yamauchi H, Kai T, Toyama N, Kiyozaki H, Fujimura A, Miyata M
Surg Endosc 1997 Sep;11(9):907-10. doi: 10.1007/s004649900484. PMID: 9294270

Prognosis

Serum IL-17 and TNFα as prognostic biomarkers in systemic sclerosis patients: a prospective study.
Kosałka-Węgiel J, Lichołai S, Pacholczak-Madej R, Dziedzina S, Milewski M, Kuszmiersz P, Korona A, Gąsior J, Matyja-Bednarczyk A, Kwiatkowska H, Zaręba L, Siwiec-Koźlik A, Koźlik-Siwiec P, Wach A, Pociej-Marciak W, Sanak M, Musiał J, Bazan-Socha S, Korkosz M
Rheumatol Int 2024 Jan;44(1):119-128. Epub 2023 Dec 5 doi: 10.1007/s00296-023-05499-9. PMID: 38051374Free PMC Article
Cytokine profile in multiple myeloma.
Jasrotia S, Gupta R, Sharma A, Halder A, Kumar L
Cytokine 2020 Dec;136:155271. Epub 2020 Sep 8 doi: 10.1016/j.cyto.2020.155271. PMID: 32916474
Interleukin-6 and cardiovascular diseases.
Kanda T, Takahashi T
Jpn Heart J 2004 Mar;45(2):183-93. doi: 10.1536/jhj.45.183. PMID: 15090695
The cytokine response to strenuous exercise.
Pedersen BK, Ostrowski K, Rohde T, Bruunsgaard H
Can J Physiol Pharmacol 1998 May;76(5):505-11. doi: 10.1139/cjpp-76-5-505. PMID: 9839076
Hormone-cytokine response. Pneumoperitoneum vs abdominal wall-lifting in laparoscopic cholecystectomy.
Yoshida T, Kobayashi E, Suminaga Y, Yamauchi H, Kai T, Toyama N, Kiyozaki H, Fujimura A, Miyata M
Surg Endosc 1997 Sep;11(9):907-10. doi: 10.1007/s004649900484. PMID: 9294270

Clinical prediction guides

Circulating markers of inflammation and angiogenesis and clinical outcomes across subtypes of pulmonary arterial hypertension.
Hirsch K, Nolley S, Ralph DD, Zheng Y, Altemeier WA, Rhodes CJ, Morrell NW, Wilkins MR, Leary PJ, Rayner SG
J Heart Lung Transplant 2023 Feb;42(2):173-182. Epub 2022 Nov 7 doi: 10.1016/j.healun.2022.10.026. PMID: 36470771Free PMC Article
Responses of complement C1q/tumor necrosis factor-related proteins to acute aerobic exercise.
Kon M, Tanimura Y
Cytokine 2023 Jan;161:156083. Epub 2022 Nov 7 doi: 10.1016/j.cyto.2022.156083. PMID: 36356496
Cytokine profile in multiple myeloma.
Jasrotia S, Gupta R, Sharma A, Halder A, Kumar L
Cytokine 2020 Dec;136:155271. Epub 2020 Sep 8 doi: 10.1016/j.cyto.2020.155271. PMID: 32916474
Interleukin-6 and cardiovascular diseases.
Kanda T, Takahashi T
Jpn Heart J 2004 Mar;45(2):183-93. doi: 10.1536/jhj.45.183. PMID: 15090695
Pattern of soluble TNF receptors I and II in sepsis.
Schröder J, Stüber F, Gallati H, Schade FU, Kremer B
Infection 1995 May-Jun;23(3):143-8. doi: 10.1007/BF01793854. PMID: 7499002

Recent systematic reviews

Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis.
Tylutka A, Walas Ł, Zembron-Lacny A
Front Immunol 2024;15:1330386. Epub 2024 Mar 1 doi: 10.3389/fimmu.2024.1330386. PMID: 38495887Free PMC Article
Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Proinflammatory cytokines levels in sepsis and healthy volunteers, and tumor necrosis factor-alpha associated sepsis mortality: A systematic review and meta-analysis.
Gharamti AA, Samara O, Monzon A, Montalbano G, Scherger S, DeSanto K, Chastain DB, Sillau S, Montoya JG, Franco-Paredes C, Henao-Martínez AF, Shapiro L
Cytokine 2022 Oct;158:156006. Epub 2022 Aug 28 doi: 10.1016/j.cyto.2022.156006. PMID: 36044827
Maternal circulating concentrations of tumor necrosis factor-alpha, leptin, and adiponectin in gestational diabetes mellitus: a systematic review and meta-analysis.
Xu J, Zhao YH, Chen YP, Yuan XL, Wang J, Zhu H, Lu CM
ScientificWorldJournal 2014;2014:926932. Epub 2014 Aug 19 doi: 10.1155/2014/926932. PMID: 25202741Free PMC Article
Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis.
Escobar-Morreale HF, Luque-Ramírez M, González F
Fertil Steril 2011 Mar 1;95(3):1048-58.e1-2. Epub 2010 Dec 17 doi: 10.1016/j.fertnstert.2010.11.036. PMID: 21168133Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...