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Abnormal circulating cytokine concentration

MedGen UID:
869117
•Concept ID:
C4023535
•
Pathologic Function
Synonym: Abnormality of serum cytokine level
 
HPO: HP:0011112

Definition

Abnormality of the cytokine levels in the blood, i.e., an abnormality of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating cytokine concentration

Professional guidelines

PubMed

A Causal Treatment for X-Linked Hypohidrotic Ectodermal Dysplasia: Long-Term Results of Short-Term Perinatal Ectodysplasin A1 Replacement.
Schneider H, Schweikl C, Faschingbauer F, Hadj-Rabia S, Schneider P
Int J Mol Sci 2023 Apr 12;24(8) doi: 10.3390/ijms24087155. PMID: 37108325Free PMC Article
Infection-associated Immune Perturbations Resolve 1 Year Following Treatment for Loa loa.
Herrick JA, Makiya MA, Holland-Thomas N, Klion AD, Nutman TB
Clin Infect Dis 2021 Mar 1;72(5):789-796. doi: 10.1093/cid/ciaa137. PMID: 32055862Free PMC Article
Nonclinical and early clinical development of tacrolimus ointment for the treatment of atopic dermatitis.
Bekersky I, Fitzsimmons W, Tanase A, Maher RM, Hodosh E, Lawrence I
J Am Acad Dermatol 2001 Jan;44(1 Suppl):S17-27. doi: 10.1067/mjd.2001.109816. PMID: 11145792

Recent clinical studies

Etiology

Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
Long noncoding RNA AK056155 involved in the development of Loeys-Dietz syndrome through AKT/PI3K signaling pathway.
Yu B, Liu L, Sun H, Chen Y
Int J Clin Exp Pathol 2015;8(9):10768-75. Epub 2015 Sep 1 PMID: 26617788Free PMC Article
Significance of circulating hepatocyte growth factor in protein-losing enteropathy after Fontan operation.
Kim GB, Kwon BS, Bae EJ, Noh CI, Choi JY
Pediatr Cardiol 2011 Oct;32(7):917-23. Epub 2011 Jun 11 doi: 10.1007/s00246-011-0014-9. PMID: 21667184
NT-proBNP and circulating inflammation markers in prediction of a normal myocardial scintigraphy in patients with symptoms of coronary artery disease.
Rathcke CN, Kjøller E, Fogh-Andersen N, Zerahn B, Vestergaard H
PLoS One 2010 Dec 1;5(12):e14196. doi: 10.1371/journal.pone.0014196. PMID: 21152016Free PMC Article
Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease.
Sarantopoulos S, Stevenson KE, Kim HT, Cutler CS, Bhuiya NS, Schowalter M, Ho VT, Alyea EP, Koreth J, Blazar BR, Soiffer RJ, Antin JH, Ritz J
Blood 2009 Apr 16;113(16):3865-74. Epub 2009 Jan 23 doi: 10.1182/blood-2008-09-177840. PMID: 19168788Free PMC Article

Diagnosis

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
The effects of vitamin D supplementation on inflammatory biomarkers in patients with abnormal glucose homeostasis: A systematic review and meta-analysis of randomized controlled trials.
Dashti F, Mousavi SM, Larijani B, Esmaillzadeh A
Pharmacol Res 2021 Aug;170:105727. Epub 2021 Jun 11 doi: 10.1016/j.phrs.2021.105727. PMID: 34126229
Placental delayed villous maturation is associated with evidence of chronic fetal hypoxia.
Jaiman S, Romero R, Pacora P, Jung EJ, Kacerovsky M, Bhatti G, Yeo L, Hsu CD
J Perinat Med 2020 Jun 25;48(5):516-518. doi: 10.1515/jpm-2020-0014. PMID: 32396141Free PMC Article
NT-proBNP and circulating inflammation markers in prediction of a normal myocardial scintigraphy in patients with symptoms of coronary artery disease.
Rathcke CN, Kjøller E, Fogh-Andersen N, Zerahn B, Vestergaard H
PLoS One 2010 Dec 1;5(12):e14196. doi: 10.1371/journal.pone.0014196. PMID: 21152016Free PMC Article
Interleukin-8 receptors in normal and psoriatic polymorphonuclear leukocytes.
Arenberger P, Kemény L, Süss R, Michel G, Peter RU, Ruzicka T
Acta Derm Venereol 1992 Sep;72(5):334-6. PMID: 1361277

Therapy

The effects of vitamin D supplementation on inflammatory biomarkers in patients with abnormal glucose homeostasis: A systematic review and meta-analysis of randomized controlled trials.
Dashti F, Mousavi SM, Larijani B, Esmaillzadeh A
Pharmacol Res 2021 Aug;170:105727. Epub 2021 Jun 11 doi: 10.1016/j.phrs.2021.105727. PMID: 34126229
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
Significance of circulating hepatocyte growth factor in protein-losing enteropathy after Fontan operation.
Kim GB, Kwon BS, Bae EJ, Noh CI, Choi JY
Pediatr Cardiol 2011 Oct;32(7):917-23. Epub 2011 Jun 11 doi: 10.1007/s00246-011-0014-9. PMID: 21667184
Obstructive nephropathy.
Klahr S
Intern Med 2000 May;39(5):355-61. doi: 10.2169/internalmedicine.39.355. PMID: 10830173
In multiple myeloma, clonotypic B lymphocytes are detectable among CD19+ peripheral blood cells expressing CD38, CD56, and monotypic Ig light chain.
Bergsagel PL, Smith AM, Szczepek A, Mant MJ, Belch AR, Pilarski LM
Blood 1995 Jan 15;85(2):436-47. PMID: 7529064

Prognosis

Long noncoding RNA AK056155 involved in the development of Loeys-Dietz syndrome through AKT/PI3K signaling pathway.
Yu B, Liu L, Sun H, Chen Y
Int J Clin Exp Pathol 2015;8(9):10768-75. Epub 2015 Sep 1 PMID: 26617788Free PMC Article
Significance of circulating hepatocyte growth factor in protein-losing enteropathy after Fontan operation.
Kim GB, Kwon BS, Bae EJ, Noh CI, Choi JY
Pediatr Cardiol 2011 Oct;32(7):917-23. Epub 2011 Jun 11 doi: 10.1007/s00246-011-0014-9. PMID: 21667184
Association of tumor necrosis factor-related apoptosis-inducing ligand with total and cardiovascular mortality in older adults.
Volpato S, Ferrucci L, Secchiero P, Corallini F, Zuliani G, Fellin R, Guralnik JM, Bandinelli S, Zauli G
Atherosclerosis 2011 Apr;215(2):452-8. Epub 2010 Nov 11 doi: 10.1016/j.atherosclerosis.2010.11.004. PMID: 21122855Free PMC Article
NT-proBNP and circulating inflammation markers in prediction of a normal myocardial scintigraphy in patients with symptoms of coronary artery disease.
Rathcke CN, Kjøller E, Fogh-Andersen N, Zerahn B, Vestergaard H
PLoS One 2010 Dec 1;5(12):e14196. doi: 10.1371/journal.pone.0014196. PMID: 21152016Free PMC Article
Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease.
Sarantopoulos S, Stevenson KE, Kim HT, Cutler CS, Bhuiya NS, Schowalter M, Ho VT, Alyea EP, Koreth J, Blazar BR, Soiffer RJ, Antin JH, Ritz J
Blood 2009 Apr 16;113(16):3865-74. Epub 2009 Jan 23 doi: 10.1182/blood-2008-09-177840. PMID: 19168788Free PMC Article

Clinical prediction guides

Oat protein isolate-Pleurotus ostreatus β-glucan conjugate nanoparticles bound to β-carotene effectively alleviate immunosuppression by regulating gut microbiota.
Zhong L, Hu Q, Zhan Q, Zhao M, Zhao L
Food Funct 2024 Feb 19;15(4):1867-1883. doi: 10.1039/d3fo05158g. PMID: 38236028
Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury.
Liu Q, Wu J, Zhang X, Li X, Wu X, Zhao Y, Ren J
Cell Death Dis 2021 Jul 3;12(7):673. doi: 10.1038/s41419-021-03961-9. PMID: 34218252Free PMC Article
Long noncoding RNA AK056155 involved in the development of Loeys-Dietz syndrome through AKT/PI3K signaling pathway.
Yu B, Liu L, Sun H, Chen Y
Int J Clin Exp Pathol 2015;8(9):10768-75. Epub 2015 Sep 1 PMID: 26617788Free PMC Article
Hepatitis C-associated osteosclerosis (HCAO): report of a new case with involvement of the OPG/RANKL system.
Fiore CE, Riccobene S, Mangiafico R, Santoro F, Pennisi P
Osteoporos Int 2005 Dec;16(12):2180-4. Epub 2005 Jun 28 doi: 10.1007/s00198-005-1858-8. PMID: 15983730
Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo.
Zoumbos NC, Gascon P, Djeu JY, Young NS
Proc Natl Acad Sci U S A 1985 Jan;82(1):188-92. doi: 10.1073/pnas.82.1.188. PMID: 3918301Free PMC Article

Recent systematic reviews

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
The effects of vitamin D supplementation on inflammatory biomarkers in patients with abnormal glucose homeostasis: A systematic review and meta-analysis of randomized controlled trials.
Dashti F, Mousavi SM, Larijani B, Esmaillzadeh A
Pharmacol Res 2021 Aug;170:105727. Epub 2021 Jun 11 doi: 10.1016/j.phrs.2021.105727. PMID: 34126229
Alcohol use disorder and circulating cytokines: A systematic review and meta-analysis.
Adams C, Conigrave JH, Lewohl J, Haber P, Morley KC
Brain Behav Immun 2020 Oct;89:501-512. Epub 2020 Aug 14 doi: 10.1016/j.bbi.2020.08.002. PMID: 32805393
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
Chronic fatigue syndrome and circulating cytokines: A systematic review.
Blundell S, Ray KK, Buckland M, White PD
Brain Behav Immun 2015 Nov;50:186-195. Epub 2015 Jul 3 doi: 10.1016/j.bbi.2015.07.004. PMID: 26148446

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