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Abnormal circulating cytokine concentration

MedGen UID:
869117
•Concept ID:
C4023535
•
Pathologic Function
Synonym: Abnormality of serum cytokine level
 
HPO: HP:0011112

Definition

Abnormality of the cytokine levels in the blood, i.e., an abnormality of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating cytokine concentration

Professional guidelines

PubMed

A Causal Treatment for X-Linked Hypohidrotic Ectodermal Dysplasia: Long-Term Results of Short-Term Perinatal Ectodysplasin A1 Replacement.
Schneider H, Schweikl C, Faschingbauer F, Hadj-Rabia S, Schneider P
Int J Mol Sci 2023 Apr 12;24(8) doi: 10.3390/ijms24087155. PMID: 37108325Free PMC Article
Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism.
Christensen MH, Pedersen EK, Nordbø Y, Varhaug JE, Midttun Ø, Ueland PM, Nygård OK, Mellgren G, Lien EA
J Intern Med 2012 Dec;272(6):583-91. Epub 2012 Aug 5 doi: 10.1111/j.1365-2796.2012.02570.x. PMID: 22757621
Nonclinical and early clinical development of tacrolimus ointment for the treatment of atopic dermatitis.
Bekersky I, Fitzsimmons W, Tanase A, Maher RM, Hodosh E, Lawrence I
J Am Acad Dermatol 2001 Jan;44(1 Suppl):S17-27. doi: 10.1067/mjd.2001.109816. PMID: 11145792

Recent clinical studies

Etiology

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
The imbalance of circulating monocyte subgroups with a higher proportion of the CD14+CD16+CD163+ phenotype in patients with preeclampsia.
Gong F, Wang J, Lu N, Wang J, Wang J, Shi X, Cui M, Cui L
Immunol Lett 2023 Jan;253:1-7. Epub 2022 Nov 29 doi: 10.1016/j.imlet.2022.11.005. PMID: 36460232
The role of chemerin in the pathogenesis of cholelithiasis in children and adolescents.
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J Paediatr Child Health 2021 Mar;57(3):371-375. Epub 2020 Oct 11 doi: 10.1111/jpc.15223. PMID: 33043555
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
Cardiovascular involvement in psoriatic arthritis.
Atzeni F, Turiel M, Boccassini L, Sitia S, Tomasoni L, Battellino M, Marchesoni A, De Gennaro Colonna V, Sarzi-Puttini P
Reumatismo 2011 Nov 9;63(3):148-54. doi: 10.4081/reumatismo.2011.148. PMID: 22257915

Diagnosis

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
The imbalance of circulating monocyte subgroups with a higher proportion of the CD14+CD16+CD163+ phenotype in patients with preeclampsia.
Gong F, Wang J, Lu N, Wang J, Wang J, Shi X, Cui M, Cui L
Immunol Lett 2023 Jan;253:1-7. Epub 2022 Nov 29 doi: 10.1016/j.imlet.2022.11.005. PMID: 36460232
The role of chemerin in the pathogenesis of cholelithiasis in children and adolescents.
Zdanowicz K, Ryzko J, Bobrus-Chociej A, Wojtkowska M, Lebensztejn DM
J Paediatr Child Health 2021 Mar;57(3):371-375. Epub 2020 Oct 11 doi: 10.1111/jpc.15223. PMID: 33043555
Hypoaminoacidemia Characterizes Chronic Traumatic Brain Injury.
Durham WJ, Foreman JP, Randolph KM, Danesi CP, Spratt H, Masel BD, Summons JR, Singh CK, Morrison M, Robles C, Wolfram C, Kreber LA, Urban RJ, Sheffield-Moore M, Masel BE
J Neurotrauma 2017 Jan 15;34(2):385-390. Epub 2016 Jun 16 doi: 10.1089/neu.2015.4350. PMID: 27178787
Clinical aspects of leptin.
Sinha MK, Caro JF
Vitam Horm 1998;54:1-30. doi: 10.1016/s0083-6729(08)60919-x. PMID: 9529971

Therapy

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Systemic and ovarian inflammation in women with polycystic ovary syndrome.
Zhai Y, Pang Y
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Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
Obstructive nephropathy.
Klahr S
Intern Med 2000 May;39(5):355-61. doi: 10.2169/internalmedicine.39.355. PMID: 10830173

Prognosis

The immunological roles in acute-on-chronic liver failure: An update.
Chen P, Wang YY, Chen C, Guan J, Zhu HH, Chen Z
Hepatobiliary Pancreat Dis Int 2019 Oct;18(5):403-411. Epub 2019 Jul 5 doi: 10.1016/j.hbpd.2019.07.003. PMID: 31303562
The possible role of bacteria, viruses, and parasites in initiation and exacerbation of irritable bowel syndrome.
Shariati A, Fallah F, Pormohammad A, Taghipour A, Safari H, Chirani AS, Sabour S, Alizadeh-Sani M, Azimi T
J Cell Physiol 2019 Jun;234(6):8550-8569. Epub 2018 Nov 27 doi: 10.1002/jcp.27828. PMID: 30480810
The concentrations of bile acids and erythropoietin in pregnant women with intrahepatic cholestasis and the state of the fetus and newborn.
Kowalska-Kańka A, Maciejewski T, Niemiec KT
Med Wieku Rozwoj 2013 Jul-Sep;17(3):232-45. PMID: 24296447
Leptin and cellular and innate immunity in abstinent alcoholics and controls.
Motivala SJ, Dang J, Obradovic T, Meadows GG, Butch AW, Irwin MR
Alcohol Clin Exp Res 2003 Nov;27(11):1819-24. doi: 10.1097/01.ALC.0000093741.21492.02. PMID: 14634499
Clinical aspects of leptin.
Sinha MK, Caro JF
Vitam Horm 1998;54:1-30. doi: 10.1016/s0083-6729(08)60919-x. PMID: 9529971

Clinical prediction guides

Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury.
Liu Q, Wu J, Zhang X, Li X, Wu X, Zhao Y, Ren J
Cell Death Dis 2021 Jul 3;12(7):673. doi: 10.1038/s41419-021-03961-9. PMID: 34218252Free PMC Article
The role of chemerin in the pathogenesis of cholelithiasis in children and adolescents.
Zdanowicz K, Ryzko J, Bobrus-Chociej A, Wojtkowska M, Lebensztejn DM
J Paediatr Child Health 2021 Mar;57(3):371-375. Epub 2020 Oct 11 doi: 10.1111/jpc.15223. PMID: 33043555
Exploring the imbalance of circulating follicular helper CD4(+) T cells in sarcoidosis patients.
Ly NTM, Ueda-Hayakawa I, Nguyen CTH, Okamoto H
J Dermatol Sci 2020 Mar;97(3):216-224. Epub 2020 Feb 8 doi: 10.1016/j.jdermsci.2020.02.002. PMID: 32063460
The immunological roles in acute-on-chronic liver failure: An update.
Chen P, Wang YY, Chen C, Guan J, Zhu HH, Chen Z
Hepatobiliary Pancreat Dis Int 2019 Oct;18(5):403-411. Epub 2019 Jul 5 doi: 10.1016/j.hbpd.2019.07.003. PMID: 31303562
Clinical aspects of leptin.
Sinha MK, Caro JF
Vitam Horm 1998;54:1-30. doi: 10.1016/s0083-6729(08)60919-x. PMID: 9529971

Recent systematic reviews

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
The effects of vitamin D supplementation on inflammatory biomarkers in patients with abnormal glucose homeostasis: A systematic review and meta-analysis of randomized controlled trials.
Dashti F, Mousavi SM, Larijani B, Esmaillzadeh A
Pharmacol Res 2021 Aug;170:105727. Epub 2021 Jun 11 doi: 10.1016/j.phrs.2021.105727. PMID: 34126229
Alcohol use disorder and circulating cytokines: A systematic review and meta-analysis.
Adams C, Conigrave JH, Lewohl J, Haber P, Morley KC
Brain Behav Immun 2020 Oct;89:501-512. Epub 2020 Aug 14 doi: 10.1016/j.bbi.2020.08.002. PMID: 32805393
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
Chronic fatigue syndrome and circulating cytokines: A systematic review.
Blundell S, Ray KK, Buckland M, White PD
Brain Behav Immun 2015 Nov;50:186-195. Epub 2015 Jul 3 doi: 10.1016/j.bbi.2015.07.004. PMID: 26148446

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