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Reduced neutrophil myeloperoxidase activity

MedGen UID:
1053720
Concept ID:
CN376971
Finding
HPO: HP:6000375

Definition

Concentration or activity of myeloperoxidase (EC 1.11.1.7) as measured in neutrophils is below the limits of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced neutrophil myeloperoxidase activity

Conditions with this feature

Myeloperoxidase deficiency
MedGen UID:
96015
Concept ID:
C0398595
Disease or Syndrome
A rare primary immunodeficiency due to a defect in innate immunity characterized by a marked decrease or absence of myeloperoxidase activity in neutrophils and monocytes. Clinically, most patients are asymptomatic. Occasionally, severe infectious complications may occur, particularly recurrent candida infections, being especially severe in the setting of comorbid diabetes mellitus.

Professional guidelines

PubMed

Sanchez-Alamo B, Schirmer JH, Hellmich B, Jayne D, Monti S, Tomasson G, Luqmani RA
RMD Open 2023 Jun;9(2) doi: 10.1136/rmdopen-2023-003083. PMID: 37349121Free PMC Article
Koening CL, von Hennigs I
Am J Manag Care 2021 Sep;27(15 Suppl):S267-S276. doi: 10.37765/ajmc.2021.88746. PMID: 34473462
Ward PA, Fattahi F
J Leukoc Biol 2019 Jul;106(1):187-192. Epub 2019 Mar 1 doi: 10.1002/JLB.4MIR1118-425R. PMID: 30821872

Recent clinical studies

Etiology

Zhu Y, Xu H, Wang T, Xie Y, Liu L, He X, Liu C, Zhao Q, Song X, Zheng L, Huang W
Environ Pollut 2023 Oct 15;335:122301. Epub 2023 Aug 2 doi: 10.1016/j.envpol.2023.122301. PMID: 37541379
Chen F, Chu C, Wang X, Yang C, Deng Y, Duan Z, Wang K, Liu B, Ji W, Ding W
Food Funct 2023 May 11;14(9):4213-4227. doi: 10.1039/d2fo02707k. PMID: 37067254
Ling S, Xu JW
Oxid Med Cell Longev 2021;2021:6687096. Epub 2021 Feb 23 doi: 10.1155/2021/6687096. PMID: 33680285Free PMC Article
Ndrepepa G
Clin Chim Acta 2019 Jun;493:36-51. Epub 2019 Feb 21 doi: 10.1016/j.cca.2019.02.022. PMID: 30797769
Hilhorst M, van Paassen P, van Rie H, Bijnens N, Heerings-Rewinkel P, van Breda Vriesman P, Cohen Tervaert JW; Limburg Renal Registry
Nephrol Dial Transplant 2017 Aug 1;32(8):1302-1313. doi: 10.1093/ndt/gfv288. PMID: 26275893

Diagnosis

Geissen S, Braumann S, Adler J, Nettersheim FS, Mehrkens D, Hof A, Guthoff H, von Stein P, Witkowski S, Gerdes N, Tellkamp F, Krüger M, Isermann L, Trifunovic A, Bunck AC, Mollenhauer M, Winkels H, Adam M, Klinke A, Buch G, Ten Cate V, Hellmich M, Kelm M, Rudolph V, Wild PS, Rosenkranz S, Baldus S
Eur J Heart Fail 2024 Oct;26(10):2269-2281. Epub 2024 Aug 30 doi: 10.1002/ejhf.3435. PMID: 39212229
Sanchez-Alamo B, Schirmer JH, Hellmich B, Jayne D, Monti S, Tomasson G, Luqmani RA
RMD Open 2023 Jun;9(2) doi: 10.1136/rmdopen-2023-003083. PMID: 37349121Free PMC Article
Krinsky N, Sizikov S, Nissim S, Dror A, Sas A, Prinz H, Pri-Or E, Perek S, Raz-Pasteur A, Lejbkowicz I, Cohen-Matsliah SI, Almog R, Chen N, Kurd R, Jarjou'i A, Rokach A, Ben-Chetrit E, Schroeder A, Caulin AF, Yost CC, Schiffman JD, Goldfeder M, Martinod K
J Thromb Haemost 2023 Sep;21(9):2569-2584. Epub 2023 Apr 11 doi: 10.1016/j.jtha.2023.02.033. PMID: 37054916Free PMC Article
Zhang N, Aiyasiding X, Li WJ, Liao HH, Tang QZ
Cell Commun Signal 2022 Apr 11;20(1):50. doi: 10.1186/s12964-022-00824-4. PMID: 35410418Free PMC Article
Varricchi G, Modestino L, Poto R, Cristinziano L, Gentile L, Postiglione L, Spadaro G, Galdiero MR
Clin Exp Med 2022 May;22(2):285-300. Epub 2021 Aug 3 doi: 10.1007/s10238-021-00750-8. PMID: 34342773Free PMC Article

Therapy

Brembach TC, Sabat R, Witte K, Schwerdtle T, Wolk K
Front Immunol 2023;14:1281685. Epub 2023 Nov 23 doi: 10.3389/fimmu.2023.1281685. PMID: 38077313Free PMC Article
Zhou G, Zhu F, Zhang H, Wang Y, Yang Y, Jin G, Wang Y, Dong G, Xiong H
FASEB J 2023 Jul;37(7):e22967. doi: 10.1096/fj.202201995RR. PMID: 37269155
Michaëlsson E, Lund LH, Hage C, Shah SJ, Voors AA, Saraste A, Redfors B, Grove EL, Barasa A, Richards AM, Svedlund S, Lagerström-Fermér M, Gabrielsen A, Garkaviy P, Gan LM, Lam CSP
JACC Heart Fail 2023 Jul;11(7):775-787. Epub 2023 May 3 doi: 10.1016/j.jchf.2023.03.002. PMID: 37140510
Chen F, Chu C, Wang X, Yang C, Deng Y, Duan Z, Wang K, Liu B, Ji W, Ding W
Food Funct 2023 May 11;14(9):4213-4227. doi: 10.1039/d2fo02707k. PMID: 37067254
Wu Y, Jha R, Li A, Liu H, Zhang Z, Zhang C, Zhai Q, Zhang J
Microbiol Spectr 2022 Dec 21;10(6):e0165122. Epub 2022 Nov 2 doi: 10.1128/spectrum.01651-22. PMID: 36321893Free PMC Article

Prognosis

Gutierrez V, Kim-Vasquez D, Shum M, Yang Q, Dikeman D, Louie SG, Shirihai OS, Tsukamoto H, Liesa M
Redox Biol 2024 Apr;70:103052. Epub 2024 Jan 24 doi: 10.1016/j.redox.2024.103052. PMID: 38290384Free PMC Article
Sanchez-Alamo B, Schirmer JH, Hellmich B, Jayne D, Monti S, Tomasson G, Luqmani RA
RMD Open 2023 Jun;9(2) doi: 10.1136/rmdopen-2023-003083. PMID: 37349121Free PMC Article
Michaëlsson E, Lund LH, Hage C, Shah SJ, Voors AA, Saraste A, Redfors B, Grove EL, Barasa A, Richards AM, Svedlund S, Lagerström-Fermér M, Gabrielsen A, Garkaviy P, Gan LM, Lam CSP
JACC Heart Fail 2023 Jul;11(7):775-787. Epub 2023 May 3 doi: 10.1016/j.jchf.2023.03.002. PMID: 37140510
Zhang N, Aiyasiding X, Li WJ, Liao HH, Tang QZ
Cell Commun Signal 2022 Apr 11;20(1):50. doi: 10.1186/s12964-022-00824-4. PMID: 35410418Free PMC Article
Ndrepepa G
Clin Chim Acta 2019 Jun;493:36-51. Epub 2019 Feb 21 doi: 10.1016/j.cca.2019.02.022. PMID: 30797769

Clinical prediction guides

Gutierrez V, Kim-Vasquez D, Shum M, Yang Q, Dikeman D, Louie SG, Shirihai OS, Tsukamoto H, Liesa M
Redox Biol 2024 Apr;70:103052. Epub 2024 Jan 24 doi: 10.1016/j.redox.2024.103052. PMID: 38290384Free PMC Article
Michaëlsson E, Lund LH, Hage C, Shah SJ, Voors AA, Saraste A, Redfors B, Grove EL, Barasa A, Richards AM, Svedlund S, Lagerström-Fermér M, Gabrielsen A, Garkaviy P, Gan LM, Lam CSP
JACC Heart Fail 2023 Jul;11(7):775-787. Epub 2023 May 3 doi: 10.1016/j.jchf.2023.03.002. PMID: 37140510
Wu Y, Jha R, Li A, Liu H, Zhang Z, Zhang C, Zhai Q, Zhang J
Microbiol Spectr 2022 Dec 21;10(6):e0165122. Epub 2022 Nov 2 doi: 10.1128/spectrum.01651-22. PMID: 36321893Free PMC Article
Zhang N, Aiyasiding X, Li WJ, Liao HH, Tang QZ
Cell Commun Signal 2022 Apr 11;20(1):50. doi: 10.1186/s12964-022-00824-4. PMID: 35410418Free PMC Article
Lood C, Blanco LP, Purmalek MM, Carmona-Rivera C, De Ravin SS, Smith CK, Malech HL, Ledbetter JA, Elkon KB, Kaplan MJ
Nat Med 2016 Feb;22(2):146-53. Epub 2016 Jan 18 doi: 10.1038/nm.4027. PMID: 26779811Free PMC Article

Recent systematic reviews

Brembach TC, Sabat R, Witte K, Schwerdtle T, Wolk K
Front Immunol 2023;14:1281685. Epub 2023 Nov 23 doi: 10.3389/fimmu.2023.1281685. PMID: 38077313Free PMC Article
Sanchez-Alamo B, Schirmer JH, Hellmich B, Jayne D, Monti S, Tomasson G, Luqmani RA
RMD Open 2023 Jun;9(2) doi: 10.1136/rmdopen-2023-003083. PMID: 37349121Free PMC Article
Gurusamy KS, Kumar Y, Sharma D, Davidson BR
Cochrane Database Syst Rev 2008 Jan 23;2008(1):CD006315. doi: 10.1002/14651858.CD006315.pub2. PMID: 18254099Free PMC Article

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