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Delta brush pattern on EEG

MedGen UID:
1054147
•Concept ID:
CN378400
•
Finding
HPO: HP:6001051

Definition

Delta brushes are transient patterns characterised by a slow delta wave with superimposed fast activity. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDelta brush pattern on EEG

Professional guidelines

PubMed

Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis: A Meta-analysis.
Nosadini M, Eyre M, Molteni E, Thomas T, Irani SR, Dalmau J, Dale RC, Lim M; International NMDAR Antibody Encephalitis Consensus Group, Anlar B, Armangue T, Benseler S, Cellucci T, Deiva K, Gallentine W, Gombolay G, Gorman MP, Hacohen Y, Jiang Y, Lim BC, Muscal E, Ndondo A, Neuteboom R, Rostásy K, Sakuma H, Sartori S, Sharma S, Tenembaum SN, Van Mater HA, Wells E, Wickstrom R, Yeshokumar AK
JAMA Neurol 2021 Nov 1;78(11):1333-1344. doi: 10.1001/jamaneurol.2021.3188. PMID: 34542573Free PMC Article

Recent clinical studies

Etiology

Interictal and seizure-onset EEG patterns in malformations of cortical development: A systematic review.
Shakhatreh L, Janmohamed M, Baker AA, Willard A, Laing J, Rychkova M, Chen Z, Kwan P, O'Brien TJ, Perucca P
Neurobiol Dis 2022 Nov;174:105863. Epub 2022 Sep 19 doi: 10.1016/j.nbd.2022.105863. PMID: 36165814
Autoimmune encephalitis and seizures, cerebrospinal fluid, imaging, and EEG findings: a case series.
Elkhider H, Sharma R, Kapoor N, Vattoth S, Shihabuddin B
Neurol Sci 2022 Apr;43(4):2669-2680. Epub 2021 Sep 26 doi: 10.1007/s10072-021-05617-0. PMID: 34564782
Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis: A Meta-analysis.
Nosadini M, Eyre M, Molteni E, Thomas T, Irani SR, Dalmau J, Dale RC, Lim M; International NMDAR Antibody Encephalitis Consensus Group, Anlar B, Armangue T, Benseler S, Cellucci T, Deiva K, Gallentine W, Gombolay G, Gorman MP, Hacohen Y, Jiang Y, Lim BC, Muscal E, Ndondo A, Neuteboom R, Rostásy K, Sakuma H, Sartori S, Sharma S, Tenembaum SN, Van Mater HA, Wells E, Wickstrom R, Yeshokumar AK
JAMA Neurol 2021 Nov 1;78(11):1333-1344. doi: 10.1001/jamaneurol.2021.3188. PMID: 34542573Free PMC Article
Continuous EEG Findings in Autoimmune Encephalitis.
Moise AM, Karakis I, Herlopian A, Dhakar M, Hirsch LJ, Cotsonis G, LaRoche S, Cabrera Kang CM, Westover B, Rodriguez A
J Clin Neurophysiol 2021 Mar 1;38(2):124-129. doi: 10.1097/WNP.0000000000000654. PMID: 31800465Free PMC Article
Delta Brush Pattern Is Not Unique to NMDAR Encephalitis: Evaluation of Two Independent Long-Term EEG Cohorts.
Baykan B, Gungor Tuncer O, Vanli-Yavuz EN, Baysal Kirac L, Gundogdu G, Bebek N, Gurses C, Altindag E, Tuzun E
Clin EEG Neurosci 2018 Jul;49(4):278-284. Epub 2017 Feb 16 doi: 10.1177/1550059417693168. PMID: 29161898

Diagnosis

Features of the EEG Pattern of Sleep Spindles and Its Diagnostic Significance in Ontogeny.
Ukhinov EB, Madaeva IM, Berdina ON, Rychkova LV, Kolesnikova LI, Kolesnikov SI
Bull Exp Biol Med 2022 Aug;173(4):399-408. Epub 2022 Sep 5 doi: 10.1007/s10517-022-05557-5. PMID: 36058972
Autoimmune encephalitis and seizures, cerebrospinal fluid, imaging, and EEG findings: a case series.
Elkhider H, Sharma R, Kapoor N, Vattoth S, Shihabuddin B
Neurol Sci 2022 Apr;43(4):2669-2680. Epub 2021 Sep 26 doi: 10.1007/s10072-021-05617-0. PMID: 34564782
Continuous EEG Findings in Autoimmune Encephalitis.
Moise AM, Karakis I, Herlopian A, Dhakar M, Hirsch LJ, Cotsonis G, LaRoche S, Cabrera Kang CM, Westover B, Rodriguez A
J Clin Neurophysiol 2021 Mar 1;38(2):124-129. doi: 10.1097/WNP.0000000000000654. PMID: 31800465Free PMC Article
EEG - A Valuable Biomarker of Brain Injury in Preterm Infants.
Pavlidis E, Lloyd RO, Boylan GB
Dev Neurosci 2017;39(1-4):23-35. Epub 2017 Apr 13 doi: 10.1159/000456659. PMID: 28402972
Anti-NMDAR Encephalitis.
Kelly LJ, Sexton VL
Neurodiagn J 2016 Jun;56(2):101-8. doi: 10.1080/21646821.2015.1137729. PMID: 27373057

Therapy

Characteristics of neonatal hypoxic-ischemic encephalopathy at high altitude and early results of therapeutic hypothermia.
Li J, Zhang G, Wang X, Qiangba C, Song X, Lin R, Huang C, Yang X, Ning S, Zhang J, Liao H, Xie S, Suo Z, Qi H, Yu Z, Shi R, Yao Y
BMC Pediatr 2023 Dec 1;23(1):609. doi: 10.1186/s12887-023-04421-3. PMID: 38037071Free PMC Article
Perioperative EEG background and discharge abnormalities in children undergoing cardiac surgery: a prospective single-centre observational study.
Lin R, Du N, Feng J, Li J, Li L, Cui Y, Ning S, Zhang M, Huang G, Wang H, Zou M, Ma L, Chen X, Li J
Br J Anaesth 2023 Aug;131(2):360-372. Epub 2023 Jun 14 doi: 10.1016/j.bja.2023.04.042. PMID: 37328305
Delta brush on EEG: a characteristic EEG finding in autoimmune encephalitis.
Saleem S, Siddiqui SJ, Qureshi FA, Kanwar D
BMJ Case Rep 2023 Feb 10;16(2) doi: 10.1136/bcr-2022-249899. PMID: 36764735Free PMC Article
Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis: A Meta-analysis.
Nosadini M, Eyre M, Molteni E, Thomas T, Irani SR, Dalmau J, Dale RC, Lim M; International NMDAR Antibody Encephalitis Consensus Group, Anlar B, Armangue T, Benseler S, Cellucci T, Deiva K, Gallentine W, Gombolay G, Gorman MP, Hacohen Y, Jiang Y, Lim BC, Muscal E, Ndondo A, Neuteboom R, Rostásy K, Sakuma H, Sartori S, Sharma S, Tenembaum SN, Van Mater HA, Wells E, Wickstrom R, Yeshokumar AK
JAMA Neurol 2021 Nov 1;78(11):1333-1344. doi: 10.1001/jamaneurol.2021.3188. PMID: 34542573Free PMC Article
EEG extreme delta brush: An ictal pattern in patients with anti-NMDA receptor encephalitis.
Veciana M, Becerra JL, Fossas P, Muriana D, Sansa G, Santamarina E, Gaig C, Carreño M, Molins A, Escofet C, Ley M, Vivanco R, Pedro J, Miró J, Falip M; Epilepsy Group of the SCN
Epilepsy Behav 2015 Aug;49:280-5. Epub 2015 Jun 10 doi: 10.1016/j.yebeh.2015.04.032. PMID: 26071995

Prognosis

Features of the EEG Pattern of Sleep Spindles and Its Diagnostic Significance in Ontogeny.
Ukhinov EB, Madaeva IM, Berdina ON, Rychkova LV, Kolesnikova LI, Kolesnikov SI
Bull Exp Biol Med 2022 Aug;173(4):399-408. Epub 2022 Sep 5 doi: 10.1007/s10517-022-05557-5. PMID: 36058972
Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis: A Meta-analysis.
Nosadini M, Eyre M, Molteni E, Thomas T, Irani SR, Dalmau J, Dale RC, Lim M; International NMDAR Antibody Encephalitis Consensus Group, Anlar B, Armangue T, Benseler S, Cellucci T, Deiva K, Gallentine W, Gombolay G, Gorman MP, Hacohen Y, Jiang Y, Lim BC, Muscal E, Ndondo A, Neuteboom R, Rostásy K, Sakuma H, Sartori S, Sharma S, Tenembaum SN, Van Mater HA, Wells E, Wickstrom R, Yeshokumar AK
JAMA Neurol 2021 Nov 1;78(11):1333-1344. doi: 10.1001/jamaneurol.2021.3188. PMID: 34542573Free PMC Article
Delta Brush Pattern Is Not Unique to NMDAR Encephalitis: Evaluation of Two Independent Long-Term EEG Cohorts.
Baykan B, Gungor Tuncer O, Vanli-Yavuz EN, Baysal Kirac L, Gundogdu G, Bebek N, Gurses C, Altindag E, Tuzun E
Clin EEG Neurosci 2018 Jul;49(4):278-284. Epub 2017 Feb 16 doi: 10.1177/1550059417693168. PMID: 29161898
Anti-NMDAR Encephalitis.
Kelly LJ, Sexton VL
Neurodiagn J 2016 Jun;56(2):101-8. doi: 10.1080/21646821.2015.1137729. PMID: 27373057
EEG extreme delta brush: An ictal pattern in patients with anti-NMDA receptor encephalitis.
Veciana M, Becerra JL, Fossas P, Muriana D, Sansa G, Santamarina E, Gaig C, Carreño M, Molins A, Escofet C, Ley M, Vivanco R, Pedro J, Miró J, Falip M; Epilepsy Group of the SCN
Epilepsy Behav 2015 Aug;49:280-5. Epub 2015 Jun 10 doi: 10.1016/j.yebeh.2015.04.032. PMID: 26071995

Clinical prediction guides

Interictal and seizure-onset EEG patterns in malformations of cortical development: A systematic review.
Shakhatreh L, Janmohamed M, Baker AA, Willard A, Laing J, Rychkova M, Chen Z, Kwan P, O'Brien TJ, Perucca P
Neurobiol Dis 2022 Nov;174:105863. Epub 2022 Sep 19 doi: 10.1016/j.nbd.2022.105863. PMID: 36165814
Features of the EEG Pattern of Sleep Spindles and Its Diagnostic Significance in Ontogeny.
Ukhinov EB, Madaeva IM, Berdina ON, Rychkova LV, Kolesnikova LI, Kolesnikov SI
Bull Exp Biol Med 2022 Aug;173(4):399-408. Epub 2022 Sep 5 doi: 10.1007/s10517-022-05557-5. PMID: 36058972
Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis: A Meta-analysis.
Nosadini M, Eyre M, Molteni E, Thomas T, Irani SR, Dalmau J, Dale RC, Lim M; International NMDAR Antibody Encephalitis Consensus Group, Anlar B, Armangue T, Benseler S, Cellucci T, Deiva K, Gallentine W, Gombolay G, Gorman MP, Hacohen Y, Jiang Y, Lim BC, Muscal E, Ndondo A, Neuteboom R, Rostásy K, Sakuma H, Sartori S, Sharma S, Tenembaum SN, Van Mater HA, Wells E, Wickstrom R, Yeshokumar AK
JAMA Neurol 2021 Nov 1;78(11):1333-1344. doi: 10.1001/jamaneurol.2021.3188. PMID: 34542573Free PMC Article
Thalamic inhibitory circuits and network activity development.
Murata Y, Colonnese MT
Brain Res 2019 Mar 1;1706:13-23. Epub 2018 Oct 23 doi: 10.1016/j.brainres.2018.10.024. PMID: 30366019Free PMC Article
Seizures in Preterm Infants.
Jacobs J, Spelbrink EM
J Clin Neurophysiol 2016 Oct;33(5):382-393. doi: 10.1097/WNP.0000000000000310. PMID: 27749458

Recent systematic reviews

Interictal and seizure-onset EEG patterns in malformations of cortical development: A systematic review.
Shakhatreh L, Janmohamed M, Baker AA, Willard A, Laing J, Rychkova M, Chen Z, Kwan P, O'Brien TJ, Perucca P
Neurobiol Dis 2022 Nov;174:105863. Epub 2022 Sep 19 doi: 10.1016/j.nbd.2022.105863. PMID: 36165814
Seizures in autoimmune encephalitis: specific features based on a systematic comparative study.
Cousyn L, Lambrecq V, Houot M, Shor N, Nguyen-Michel VH, Frazzini V, Dupont S, Demeret S, Navarro V
Epileptic Disord 2021 Dec 1;23(6):879-892. doi: 10.1684/epd.2021.1355. PMID: 34704941

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